Datasets

Summary: These sequences support the following paper abstract: "Clinical and genetic research links altered cholesterol metabolism with ALS development and progression, yet pinpointing specific pathomechanisms remain challenging. We investigated how cholesterol dysmetabolism interacts with protein aggregation, demyelination, and neuronal loss in ALS. [...]

Summary: Aging is the major risk factor for neurodegeneration and associated with structural and functional alterations in white matter. Myelin is particularly vulnerable to aging resulting in white matter-associated microglia activation. [...]

Supplementary Material 1

Additional file 1 This excel sheet contains detailed information on all subjects (patients and controls) analyzed in this study including age and sex and disease parameter for ALS patients..

Additional file 3: Supplementary Excel File 1a. DEPs from 5xFAD versus wild-type tissue comparisons in hippocampus and cortex; DEPs were defined using the “pairwise model”; Supplementary Excel File 1b. [...]

Additional file 1: Table S1. Metabolite quantification and normalization in KORA F4 [...]

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Abstract Background Given that, up to date, there is no effective strategy to treat dementia, a timely start of interventions in a prodromal stage such as mild cognitive impairment (MCI) is considered an important option to lower the overall societal burden. Although autonomic functions have been related to cognitive performance, both aspects have rarely been studied simultaneously in MCI. [...]