Datasets

We performed global gene expression profile to investigate impact of GBA mutation on cellular function of dopaminergic neuronsPathway analyses of differentially regulated genes revealed mitochondrial function as one of the most dysregulated pathways in patient neurons, thus confirming the impact of GBA mutations on mitochondria

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder causing about two third of all dementia cases in the elderly. Although AD pathological features have been intensively examined in numerous scientific studies employing invertebrate and vertebrate model organisms, the exact underlying mechanisms remain poorly understood. [...]

Despite extensive research, the contribution of the LRRK2 p.G2019S mutation to Parkinson's disease (PD) remains unclear. Recent findings indicate oligodendrocytes (ODCs) and their progenitors are vulnerable in PD pathogenesis. [...]

Aging is a key risk factor for disease in mammals, yet its molecular basis across organs remains unclear. Here, we performed bulk RNA sequencing on eight organs (brain, heart, kidney, liver, lung, skeletal muscle, spleen, testis) from male C57BL/6J mice at distinct life stages. [...]

Alzheimer's disease (AD) often begins with non-cognitive symptoms such as olfactory deficits, which can predict later cognitive decline, though the mechanisms remain unclear. Pathologically, the brainstem locus coeruleus (LC), the main source of the neurotransmitter noradrenalin (NA) modulating olfactory information processing is affected ealy. [...]

Neuronal communication relies on precisely maintained synaptic vesicle (SV) clusters, which assemble via liquid-liquid phase separation. This process requires synapsins, the major synaptic phosphoproteins, which are known to bind actin. [...]