Datasets

This dataset contains epigenome-wide association study (EWAS) summary statistics for ten diet quality scores from the Rhineland Study, a population-based cohort (n = 5,768 participants).Traits included (diet quality scores): Mediterranean Diet Score (MDS), Dietary Approaches to Stop Hypertension (DASH), Mediterranean–DASH Intervention for Neurodegenerative Delay (MIND), Alternate Healthy Eating Index (AHEI), Nordic diet score, Plant-based Diet Index (PDI), Healthful Plant-based Diet Index (hPDI), Unhealthful Plant-based Diet Index (uPDI), Dietary Inflammatory Index (DII), and EAT-Lancet diet score.The repository also includes generic scripts, adapted for general use, for calculating adherence to the diet quality scores, performing the EWAS analyses, generating the descriptive tables, and fitting the linear regression models for the associations between the diet quality scores and epigenetic aging outcomes.This work accompanies the manuscript "Associations between diet quality, epigenetic aging, and the epigenome: Findings from two population-based studies."

Bulk RNA-seq dataset of microglia isolated from a transgenic Parkinson's disease mouse model (Camk2a-tTA; V1S/SV2 α-synuclein). Microglia were enriched from adult brain by enzymatic dissociation (Miltenyi Adult Brain Dissociation Kit), Anti-O4 oligodendrocyte depletion, and CD11b positive selection (~2 M cells per pooled sample). [...]

Data and analysis code accompanying the manuscript "An intrinsic cytoskeletal oscillator establishes neuronal polarity". The study shows that the neuronal soma acts as a central organiser of axon–dendrite polarity through a soma-initiated, Arp2/3-driven actin oscillator: periodic somatic actin waves remodel a global actomyosin network, transiently relax myosin-II contractility at a single neurite tip, and bias that neurite toward axon fate. [...]

This dataset contains epigenome-wide association study (EWAS) meta-analysis summary statistics for hippocampal imaging traits from six population-based cohorts (n = 8,156 participants). Traits included:- left hippocampal volume (LHCV)- right hippocampal volume (RHCV)- hippocampal asymmetry (HCasy)- sex-stratified HCasy analysesThe repository also includes generic scripts used to perform cohort-level EWAS analyses..

The variant annotations used in the manuscript "Genomic foundation models do not yet boost common variant discovery", on ~7M 1000 Genomes EUR SNPs (MAF > 0.01). The models included are AlphaGenome (eight output types), the 102 principal components of Borzoi variant effect scores (Sniff), GPN-Star constraint scores (three, with their top-0.1% indicators), Zoonomia constraint (two), the AlphaGenome variant impact score (AVI), and the 96 baselineLD (v2.2) annotations..

This dataset accompanies the study entitled “Hypoxia-inducible factor 2α does not regulate cortical brain development”.ContentThe dataset contains the underlying data supporting the findings of the study, including quantitative analysis files and original Western blot images.The dataset includes:Data generated from neural stem cells (NSCs) isolated from HIF-2αflox/flox control mice and NesCre-HIF-2α conditional knockout (CKO) mice, including:cell counts and immunocytochemistry analysesquantitative PCR dataprotein expression analysesData generated from in vivo analyses of HIF-2αflox/flox control mice and NesCre-HIF-2α CKO mice, including:immunocytochemistry analysesquantitative PCR dataData generated from in vivo analyses of HIF-2αflox/flox control mice and Emx1Cre-HIF-2α CKO mice, including:immunocytochemistry analysesOriginal, uncropped Western blot images generated during the study.All data files are provided in formats suitable for reuse and verification of the reported results. Additional InformationFor further information regarding the dataset or the associated study, please contact the corresponding author..

The shared code was created to perform analyses for the article "Understanding the pattern of cognitive decline in GBA1-related Parkinson’s Disease: an exploratory longitudinal multi-cohort study".This code was created to analyze data from three cohorts:1. The PPMI study, downloaded from database (RRID:SCR_006431) on May 22, 2025. [...]

The shared code was created to perform analyses for the article "Understanding the pattern of cognitive decline in GBA1-related Parkinson’s Disease: a longitudinal multi-cohort study".This code was created to analyze data from three cohorts:1. The PPMI study, downloaded from database (RRID:SCR_006431) on May 22, 2025. [...]

Model weights for YADO (You Accurately Denoise real Observations) Denoiser and Renoiser as introduced in the paper "Rethinking Real-World MRI Denoising: Learning from Physical Noise" accepted to ECCV 2026. See also the Project Page.The code and docs are at: github.com/Deep-MI/YADO, and the weights are mostly also compatible with YODA. [...]

Data and code for the publication "A novel analysis method for condensate wetting identifies charge-dependent Tau-membrane interactions", located at [DOI will be updated when available]..