Datasets

To obtain a general TR catalog across the human genome, we identified genomic intervals with a stretch of approximate repetitions of a DNA motif ranging from 1-6bp on GRCh38 autosomes and sex chromosomes by using STRfinder (v1.0), and each STR region was annotated based on gencode.V38 (https://www.gencodegenes.org/human/release_38.html). To end up, we successfully found 1,656,159 TR intervals, covering 1.107653% (34.2 Mbp) of GRCh38 (https://console.cloud.google.com/storage/browser/_details/genomics-public-data/resources/broad/hg38/v0/Homo_sapiens_assembly38.fasta)..

30 sec raw data (.brw) was recorded with BrainWave SW and detected LFP events and spikes were stored in (.bxr). These extracellular recordings were obtained from acute hippocampal-cortical slices and were collected at 14KHz/electrode sampling frequency..

Myelin lipidome of Gltp cKO (Cnp-Cre Gltpflox/flox) and Cre control (Cnp-Cre) mice at postnatal day 14 and 28 (P14 and P28). n=4 mice for each genotype/time point [...]

These are the data sets and plasmid sequences of the viral vectors used in the study 'Mitochondrial oxidant stress promotes alpha-synuclein aggregation and spreading in mice with mutated glucocerebrosidase'

Supportive data for the eLife version of record. (1) Data used for the Michaelis Menten Kinetics. [...]

AlphaFold3 model of LRRK2-pT1343 either bound to GDP/Mg or GTP/Mg. Using AlphaFold3 (Abramson et al., 2024), we modeled and compared the GDP vs the GTP-state of phospho-T1343 LRRK2. [...]

In April 2024, GP2 announced the seventh data release on the Terra and the Verily® Workbench platforms in collaboration with AMP® PD. This release includes >9,000 additional genotyped participants [...]

In December 2023, GP2 announced the sixth data release on the Terra and the Verily® Workbench platforms in collaboration with AMP® PD. This release includes >20,000 additional participants, adding to the previous releases from the Complex and Monogenic Networks [...]

In May 2023, GP2 announced the fifth data release on the Terra platform in collaboration with AMP® PD. This release includes 7,462 additional new complex disease participants and 487 new monogenic disease participants, adding to the previous releases from the Complex and Monogenic Networks [...]

Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson's disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from post-mortem control and PD brain tissue. [...]