Datasets

Using 6-months, 16-months, and 24-months old mice of a inducible expression of human a-syn constructs based Parkinson mouse model, we produced a single nucleus RNA dataset by cutting 0mm Bregma to -5mm Bregma. The Chromium 3’ Single Cell Library Kit (10x Genomics) was used and Sequencing was performed on a NovaSeq 6000 [...]

Open data repository, Knab et al., Prediction of stroke outcome in mice based on non-invasive MRI and behavioral testing Latest version of files: repository_v2.0.zip, Behavior Data_v2.0.xlsx and MRI IDs Testing&Replication Cohort.xlsx (please ignore repository.zip) Open data repository Knab et al. Prediction of stroke outcome in mice based on non-invasvive MRI and behavioral testing Open code and documentation of prediction models available via https://github.com/major-s/mouse-mcao-outcome-predictor Content: README.txt This information dat Contains MRI data in NIFTI format and secondary data from atlas registration [...]

Source data file for the manuscript 'The mitochondrial unfolded protein response promotes senescence in human microglia by increasing S-adenosylmethionine availability for polyamine synthesis'. https://www.biorxiv.org/content/10.1101/2024.09.03.610925v1.full Authors: Maria Jose Perez J., Federico Bertoli, Hariam Raji, Alicia Lam, Mariella Bosch, Christin Weissleder, Ivan Nemazanyy, Stefanie Kalb, Insa Hirschberg, Dario Brunetti, Indra Heckenbach, Morten Scheibye-Knudsen, Michela Deleidi

These are the vessel pattern atlases generated in 'Assessing arterial patterns in the motor cortex with 7 Tesla magnetic resonance imaging and vessel distance mapping.' The atlases are provided in the MNI152 NLIN 2009b space (at 0.5 mm isotropic resolution) as vessel labels and represent the majority votes per voxel (details in manuscript). They are provided for left and right hemisphere, respectively. [...]

Loss-of-function mutations in the homotrimeric serine protease HTRA1 cause cerebral vasculopathy. Here, we show that disease-causing mutations targeting the protomer-protomer interface impair trimerization. [...]

The 18 kDa translocator protein (TSPO) emerges as an important PET biomarker to assess the tumor microenvironment (TME) in glioblastoma. However, various cellular sources hamper interpretation and biological understanding of TSPO and other immune biomarkers in the TME. [...]