Datasets

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2023-01-27
15:14
[DZNE-2023-00190] Dataset
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CSF proteomics of the APPPS1 Alzheimer mouse model with life long BACE inhibition
PRoteomics IDEntifications Database ()
The earliest defining event in the pathogenesis of Alzheimer´s disease (AD) is the intracerebral deposition of Abeta, which starts at least 20 years before the onset of dementia. The link between Abeta and downstream neurodegeneration leading to dementia remains unclear, a critical gap in knowledge at a time when clinical trials are increasingly shifting to pre-symptomatic disease stages. [...]
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2023-01-27
15:08
[DZNE-2023-00189] Dataset
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LncRNA RUS shapes the gene expression program towards neurogenesis
PRoteomics IDEntifications Database ()
The evolution of brain complexity correlates with an increased expression of long, non-coding (lnc) RNAs in neuronal tissues. Although prominent examples illustrate the potential of lncRNAs to scaffold and target epigenetic regulators to chromatin loci, only few cases have been described to function during neurogenesis. [...]
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2023-01-27
15:04
[DZNE-2023-00188] Dataset

Mapping of TDP-43 ubiquitination and acetylation sites
PRoteomics IDEntifications Database ()
TAR DNA binding protein of 43 kDa (TDP-43) forms aggregates in neurodegenerative diseases, particularly certain forms of frontotemporal dementia and amyotrophic lateral sclerosis. Pathological modifications of TDP-43 include proteolytic fragmentation, phosphorylation, and ubiquitinylation. [...]
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2023-01-27
15:02
[DZNE-2023-00187] Dataset

Mapping of nanobody binding sites on human LRRK2 by CX-MS
PRoteomics IDEntifications Database ()
As part of an in-depth characterization of nanobodies directed against the human Leucine-rich repeat kinase 2 (LRRK2), epitopes of the nanobodies bound to LRRK2 were mapped by chemical crosslinking combined with mass spectrometry using the CID-cleavable crosslinker disuccinimidyl sulfoxide (DSSO)..
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2023-01-27
14:58
[DZNE-2023-00186] Dataset
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Cerebrospinal Fluid (CSF) Proteomics of A30P-αS mice
PRoteomics IDEntifications Database ()
Here, we took advantage of well-defined mouse models for α-synucleinopathy (A30P-αS ) to explore proteome changes in the cerebrospinal fluid which are related to these distinct proteopathic lesions. Non-targeted liquid chromatography-mass spectrometry revealed that the majority of proteins that undergo age- and disease-related changes in either mouse model was linked to microglia, and more specifically to previously described disease state-specific microglia transcriptomic signatures. [...]
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2023-01-27
14:56
[DZNE-2023-00185] Dataset
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Cerebrospinal Fluid (CSF) Proteomics of APPPS1 mice
PRoteomics IDEntifications Database ()
Here, we took advantage of well-defined mouse models for β-amyloidosis (APPPS1) to explore proteome changes in the cerebrospinal fluid which are related to these distinct proteopathic lesions. Non-targeted liquid chromatography-mass spectrometry revealed that the majority of proteins that undergo age- and disease-related changes in either mouse model was linked to microglia, and more specifically to previously described disease state-specific microglia transcriptomic signatures. [...]
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2023-01-27
14:52

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2023-01-27
14:47
[DZNE-2023-00183] Dataset
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Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process
We employed large-scale phenotyping to analyze not only a few, but hundreds of phenotypes and thousands of molecular markers across tissues and organ systems in a single study in aging C57BL/6J mice. For each phenotype, we established lifetime profiles to determine at which age age-dependent phenotypic change is first detectable relative to the young adult baseline..
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2023-01-27
14:33
[DZNE-2023-00182] Dataset
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Silencing of exercise induced microRNA-501, microRNA-409 leads to aberrant neuronal homeostasis
Gene Expression Omnibus ()
Exercise has been shown to boost cognition in mammals. However, the underlying mechanism remain poorly understood. [...]
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2023-01-27
14:30
[DZNE-2023-00181] Dataset
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Beneficial effect of ACI-24 vaccination on microglial phenotypes in an amyloidosis mouse model
PRoteomics IDEntifications Database ()
Amyloid-beta (Aβ) deposition is an initiating factor in Alzheimer´s disease (AD). Microglia are the brain immune cells that surround and phagocytose Aβ, but their phagocytic capacity declines in AD. [...]
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