Vita Publications

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2021-10-04
15:30
DBCoverage [DZNE-2021-01291] Journal Article
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Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice
Background and aims: The presence of tertiary lymphoid structures (TLSs) may confer survival benefit to patients with pancreatic ductal adenocarcinoma (PDAC), in an otherwise immunologically inert malignancy. Yet, the precise role in PDAC has not been elucidated. [...]

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2021-09-29
07:24

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2021-09-21
10:10
DBCoverage [DZNE-2021-01166] Journal Article
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Evidence for similar structural brain anomalies in youth and adult attention-deficit/hyperactivity disorder: a machine learning analysis.
Attention-deficit/hyperactivity disorder (ADHD) affects 5% of children world-wide. Of these, two-thirds continue to have impairing symptoms of ADHD into adulthood. [...]

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2021-09-20
14:04
[DZNE-2021-01131] Journal Article
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Towards chronic deep brain stimulation in freely moving hemiparkinsonian rats: Applicability and functionality of a fully implantable stimulation system.
Objective This study aimed at investigating a novel fully implantable deep brain stimulation system and its ability to modulate brain metabolism and behavior through subthalamic nucleus stimulation in a hemiparkinsonian rat model. Approach Twelve male rats were unilaterally lesioned with 6-hydroxydopamine in the medial forebrain bundle and received a fully implantable deep brain stimulation system aiming at the ipsilesional subthalamic nucleus. [...]

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2021-09-16
17:02
pmc [DZNE-2021-01099] Journal Article
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Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy.
Cell stem cell 17(5), 569 - 584 () [10.1016/j.stem.2015.08.003]
Spinal muscular atrophy (SMA) is caused by mutations in the SMN1 gene. Because this gene is expressed ubiquitously, it remains poorly understood why motor neurons (MNs) are one of the most affected cell types. [...]

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2021-09-16
17:01
DBCoverage [DZNE-2021-01098] Journal Article
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Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa.
Retinitis pigmentosa (RP) is a heterogeneous group of inherited conditions that lead to blindness and for which there is no effective therapy. Apoptosis of photoreceptors is a common feature in animal models of the disease. [...]

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2021-09-16
17:00
pmc [DZNE-2021-01097] Journal Article
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Pathogenic lysosomal depletion in Parkinson's disease.
Mounting evidence suggests a role for autophagy dysregulation in Parkinson's disease (PD). The bulk degradation of cytoplasmic proteins (including α-synuclein) and organelles (such as mitochondria) is mediated by macroautophagy, which involves the sequestration of cytosolic components into autophagosomes (AP) and its delivery to lysosomes. [...]

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2021-09-16
16:59

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2021-09-16
16:59
[DZNE-2021-01095] Journal Article
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Axonal damage, autophagy and neuronal survival.
Autophagy 8(2), 286 - 288 () [10.4161/auto.8.2.18982]
In recent years autophagy modulation has been shown to reduce or increase neuronal cell death in several models of neurodegeneration. How autophagy exerts these dual effects is currently unknown. [...]

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2021-09-16
16:57
DBCoverage [DZNE-2021-01094] Journal Article
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Balance between autophagic pathways preserves retinal homeostasis.
Aging cell 12(3), 478 - 488 () [10.1111/acel.12072]
Aging contributes to the appearance of several retinopathies and is the largest risk factor for aged-related macular degeneration, major cause of blindness in the elderly population. Accumulation of undegraded material as lipofuscin represents a hallmark in many pathologies of the aged eye. [...]

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