Vita Publications

Latest additions:
2022-05-24
14:28
OpenAccess [DZNE-2022-00791] Journal Article
; ; ; et al
Evidence for similar structural brain anomalies in youth and adult attention-deficit/hyperactivity disorder: a machine learning analysis.
Attention-deficit/hyperactivity disorder (ADHD) affects 5% of children world-wide. Of these, two-thirds continue to have impairing symptoms of ADHD into adulthood. [...]
OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);

Detailed record - Similar records
2022-05-07
13:47
pmc [DZNE-2022-00586] Journal Article
; ; ; et al
Phosphoinositides: lipid regulators of membrane proteins.
The journal of physiology 588(Pt 17), 3179 - 3185 () [10.1113/jphysiol.2010.192153]
Phosphoinositides are a family of minority acidic phospholipids in cell membranes. Their principal role is instructional: they interact with proteins. [...]

Detailed record - Similar records
2022-05-07
13:46
pmc [DZNE-2022-00585] Journal Article
; ;
Kinetics of PIP2 metabolism and KCNQ2/3 channel regulation studied with a voltage-sensitive phosphatase in living cells.
The signaling phosphoinositide phosphatidylinositol 4,5-bisphosphate (PIP(2)) is synthesized in two steps from phosphatidylinositol by lipid kinases. It then interacts with KCNQ channels and with pleckstrin homology (PH) domains among many other physiological protein targets. [...]

Detailed record - Similar records
2022-05-07
13:46
pmc [DZNE-2022-00584] Journal Article
; ;
Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells.
G protein-coupled receptors (GPCRs) mediate responses to external stimuli in various cell types. Early events, such as the binding of ligand and G proteins to the receptor, nucleotide exchange (NX), and GTPase activity at the Galpha subunit, are common for many different GPCRs. [...]

Detailed record - Similar records
2022-05-07
13:45
[DZNE-2022-00583] Journal Article
; ; ; et al
Accumulation and clearance of alpha-synuclein aggregates demonstrated by time-lapse imaging.
Aggregates of alpha-synuclein are the pathological hallmark of sporadic Parkinson's disease (PD), and mutations in the alpha-synuclein gene underlie familial forms of the disease. To characterize the formation of alpha-synuclein aggregates in living cells, we developed a new strategy to visualize alpha-synuclein by fluorescence microscopy: alpha-synuclein was tagged with a six amino acid PDZ binding motif and co-expressed with the corresponding PDZ domain fused to enhanced green fluorescent protein (EGFP). [...]

Detailed record - Similar records
2022-05-07
13:44
pmc [DZNE-2022-00582] Journal Article
; ; ; et al
Triggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganization.
A limited set of phosphoinositide membrane lipids regulate diverse cellular functions including proliferation, differentiation, and migration. We developed two techniques based on rapamycin-induced protein dimerization to rapidly change the concentration of plasma membrane phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)]. [...]

Detailed record - Similar records
2022-05-07
13:44
[DZNE-2022-00581] Journal Article
; ; ; et al
Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease.
Parkinson's disease is characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. The heat-shock protein 70 (Hsp70) reduces protein misfolding and aggregation. [...]

Detailed record - Similar records
2022-05-07
13:43
DBCoverage [DZNE-2022-00580] Journal Article
; ; ; et al
Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.
Transgenic RNAi, an alternative to the gene knockout approach, can induce hypomorphic phenotypes that resemble those of the gene knockout in mice. Conditional transgenic RNAi is an attractive choice of method for reverse genetics in vivo because it can achieve temporal and spatial silencing of targeted genes. [...]

Detailed record - Similar records
2022-05-07
13:42
[DZNE-2022-00579] Journal Article
; ;
PKC links Gq-coupled receptors to DAT-mediated dopamine release.
The dopamine transporter (DAT) mediates dopamine uptake in many brain areas and has been suggested to underlie dopamine release in the substantia nigra pars reticulata. This release modulates basal ganglia output and motor performance. [...]

Detailed record - Similar records
2022-05-07
13:41
[DZNE-2022-00578] Journal Article
; ; ; et al
Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson's disease.
Brain 135(Pt 6), 1914 - 1925 () [10.1093/brain/aws054]
Recent proof-of-principle data showed that the haematopoietic growth factor granulocyte colony-stimulating factor (filgrastim) mediates neuroprotection in rodent models of Parkinson's disease. In preparation for future clinical trials, we performed a preclinical characterization of a pegylated derivative of granulocyte colony-stimulating factor (pegfilgrastim) in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. [...]

Detailed record - Similar records