Vita Publications

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2024-06-12
10:03
[DZNE-2024-00757] Preprint

Transfer entropy as a tool for inferring causality from observational studies in epidemiology
Recently Wiener's causality theorem, which states that one variable could be regarded as the cause of another if the ability to predict the future of the second variable is enhanced by implementing information about the preceding values of the first variable, was linked to information theory through the development of a novel metric called 'transfer entropy'. Intuitively, transfer entropy can be conceptualized as a model-free measure of directed information flow from one variable to another. [...]
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2024-06-03
13:37
[DZNE-2024-00730] Journal Article (Review Article)
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Blood-based transcriptomics: leukemias and beyond.
In 1999, Golub et al. proposed for the first time microarray-based transcriptional profiling to be used as a new technology for the differential diagnosis of acute myeloid leukemias and acute lymphocytic leukemias. [...]

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2024-06-03
13:36
[DZNE-2024-00729] Journal Article (Review Article)
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Regulatory T cells: major players in the tumor microenvironment.
Over the last years a number of reports have described elevated numbers of regulatory T (Treg) cells inside of tumors, in close proximity of the tumor, draining lymph nodes and also in peripheral blood of patients with solid tumors and hematologic malignancies. There is increasing evidence that Treg cells can migrate into tumors and suppress effective anti-tumor responses in the tumor microenvironment, thus contributing to the prosperity and growth of human tumors. [...]

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2024-06-03
13:35
[DZNE-2024-00728] Journal Article (Review Article)
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Taking off the brakes: T cell immunity in the liver.
Trends in immunology 31(8), 311 - 317 () [10.1016/j.it.2010.06.001]
In lymphatic tissue, professional antigen-presenting cells (APCs) such as dendritic cells (DCs), mature after sensing microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs), and subsequently activate T cell immunity. Non-pathogenic MAMPs, derived for example from commensal bacteria, are delivered to the liver from the gastrointestinal tract via the portal vein. [...]

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2024-06-03
13:33
pmc [DZNE-2024-00727] Journal Article
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Prediction and prognosis: impact of gene expression profiling in personalized treatment of breast cancer patients.
The EPMA journal 1(3), 421 - 437 () [10.1007/s13167-010-0044-z]
Breast cancer is a complex disease, whose heterogeneity is increasingly recognized. Despite considerable improvement in breast cancer treatment and survival, a significant proportion of patients seems to be over- or undertreated. [...]

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2024-06-03
13:32

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2024-06-03
13:30
[DZNE-2024-00725] Journal Article (Review Article)
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Plasticity of T(reg) cells: is reprogramming of T(reg) cells possible in the presence of FOXP3?
Regulatory T cells (T(reg) cells) are involved in self tolerance, immune homeostasis, prevention of autoimmunity, and suppression of immunity to pathogens or tumors. The forkhead transcription factor FOXP3 is essential for T(reg)-cell development and function as mutations in FOXP3 cause severe autoimmune diseases in mice and humans. [...]

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2024-06-03
13:27
DBCoverage [DZNE-2024-00724] Journal Article (Review Article)
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Regulatory dendritic cells: there is more than just immune activation.
The immune system exists in a delicate equilibrium between inflammatory responses and tolerance. This unique feature allows the immune system to recognize and respond to potential threats in a controlled but normally limited fashion thereby preventing a destructive overreaction against healthy tissues. [...]

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2024-06-03
13:20
pmc [DZNE-2024-00723] Journal Article (Editorial)

Precision attack on calcineurin in macrophages: a new anti-inflammatory weapon.
The EMBO journal 33(10), 1087 - 1088 () [10.1002/embj.201488178]
Inflammation is a hallmark of many common diseases ranging from arthritis, atherosclerosis, or obesity to Alzheimer's disease and cancer. Identifying antiinflammatory mechanisms is therefore an important and timely task of modern biomedicine. [...]

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2024-06-03
13:13
pmc [DZNE-2024-00722] Journal Article
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Macrophage activation and polarization: nomenclature and experimental guidelines.
Immunity 41(1), 14 - 20 () [10.1016/j.immuni.2014.06.008]
Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. [...]

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