Vita Publications

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2023-06-20
15:15
[DZNE-2023-00643] Journal Article
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A baseline study for detection of Parkinson's disease with 3D-transcranial sonography and uni-lateral reconstruction.
TCS is a well-established technique for diagnosis of Parkinson's disease (PD). Volumetric 3D-TCS is a promising complementary approach for objective acquisition and analysis, in particular for less experienced sonographers. [...]
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2023-06-20
15:11
[DZNE-2023-00642] Journal Article
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FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells.
Oncogene 31(8), 1045 - 1054 () [10.1038/onc.2011.293]
The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. [...]
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2023-06-20
14:53
[DZNE-2023-00641] Journal Article (Review Article)
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Epigenetic and transcriptional control of Foxp3+ regulatory T cells.
Regulatory T cells (Treg cells) present a unique T-cell lineage that plays a key role for the initiation and maintenance of immunological tolerance. Treg cells are characterized by the expression of the forkhead box transcription factor Foxp3, which acts as a lineage-specifying factor and determines the unique properties of these immunosuppressive cells. [...]
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2023-06-20
11:23
[DZNE-2023-00631] Journal Article
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Expression of polymeric immunoglobulin receptor and stromal activity in pancreatic ductal adenocarcinoma.
Pancreatology 17(2), 295 - 302 () [10.1016/j.pan.2017.01.013]
Polymeric immunoglobulin receptor (pIgR) traffics Immunoglobulins (IgA and IgM) through epithelial cells in normal mucosae but neither are expressed in the normal pancreas. Recent work from our laboratory suggested pIgR may be upregulated in pancreatic ductal adenocarcinoma (PDAC). [...]
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2023-06-20
11:22
pmc [DZNE-2023-00630] Journal Article
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A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases.
In high-grade serous ovarian cancer (HGSOC), higher densities of both B cells and the CD8+ T-cell infiltrate were associated with a better prognosis. However, the precise role of B cells in the antitumor response remains unknown. [...]
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2023-06-20
11:21
pmc [DZNE-2023-00629] Journal Article
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Mechanisms of PD-L1/PD-1-mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model.
Blood 126(2), 212 - 221 () [10.1182/blood-2015-02-626754]
T-cell defects, immune suppression, and poor antitumor immune responses are hallmarks of chronic lymphocytic leukemia (CLL), and PD-1/PD-L1 inhibitory signaling has emerged as a major immunosuppressive mechanism. However, the effect of different microenvironments and the confounding influence of aging are poorly understood. [...]
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2023-06-20
11:20

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2023-06-20
11:19
pmc [DZNE-2023-00627] Journal Article
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Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells.
HVCN1 (Hydrogen voltage-gated channel 1) is the only mammalian voltage-gated proton channel. In human B lymphocytes, HVCN1 associates with the B-cell receptor (BCR) and is required for optimal BCR signaling and redox control. [...]
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2023-06-20
11:18
pmc [DZNE-2023-00626] Journal Article (Review Article)

Regulation of immune responses by proton channels.
Immunology 143(2), 131 - 137 () [10.1111/imm.12326]
The identification of the HVCN1 gene, encoding the only mammalian voltage-gated proton channel, prompted a number of studies on how proton channels affect cellular functions. As their expression is mainly restricted to immune cells, it is not surprising that proton channels regulate different aspects of immune responses. [...]
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2023-06-20
11:17
pmc [DZNE-2023-00625] Journal Article

Proton channels in non-phagocytic cells of the immune system.
Proton channels are expressed in all cells of the immune system to various degrees. While their function in phagocytic cells, immune cells that engulf bacteria and cell debris for clearance, has been the object of extensive research, the function of proton channels in non-phagocytic cells has remained more elusive until recently. [...]
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