Journal Article (Review Article)

DZNE-2025-00366

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png One gene, two paracellular ion channels—claudin-10 in the kidney

Milatz, S. ; Breiderhoff, T.Extern*

2017
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00424-016-1921-7

Abstract: Claudins are tight junction membrane proteins and regulate the paracellular passage of ions and water. They can seal the paracellular cleft against solute passage but also form paracellular channels. They are tetraspan proteins with two extracellular segments. Claudin-10 exists in at least two functional isoforms, claudin-10a and claudin-10b, that differ in their first transmembrane segment and first extracellular segment. Both isoforms act as selective paracellular ion channels, either for anions (claudin-10a) or for cations (claudin-10b). Their diverse functions are reflected in completely different expression patterns in the body, especially in the kidney. Their structural and functional similarities and differences make them ideal subjects to study determinants of claudin charge selectivity and pore formation. This review aims to summarise research on permeability properties of the claudin-10 channels and their role in physiology and pathophysiology of the kidney.

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Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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