Full Text Collection

Alzheimer's disease (AD) is the leading cause of dementia, characterized by the accumulation of amyloid-beta (Aβ) and neurofibrillary tangles. Recent studies emphasize the role of vascular factors, including the glymphatic system, in AD pathogenesis, particularly in Aβ clearance. [...]

Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson's disease but also one of the most common co-pathologies in Alzheimer's disease (AD). Preclinical studies suggest that αSyn can exacerbate tau aggregation, implying that αSyn co-pathology may specifically contribute to the Aβ-induced aggregation of tau that drives neurodegeneration and cognitive decline in AD. [...]

Little is known about social gradients in cause-specific infant mortality in the nineteenth century. To our knowledge, this is the first paper to explore this connection for the time prior to the epidemiologic and demographic transitions. [...]

Accurate estimation of brain myelin-water content from multi-echo data is challenging due to the inherent ill-posedness of the inversion problem. In this study, we propose a novel method for myelin-water imaging that jointly utilizes gradient-echo and spin-echo imaging data to enhance the accuracy of myelin-water estimation.Multi-echo gradient-echo and spin-echo data were simulated and acquired in vivo. [...]

Chemotherapy-induced peripheral neuropathy (CIPN) and post-chemotherapy cognitive impairment (PCCI) represent major side effects of chemotherapy. Using Sendai virus vectors, ten hiPSC lines from patients who had undergone chemotherapy and did or did not develop CIPN and PCCI were generated. [...]

The characterization of physiological immune signatures in a population-based cohort is a prerequisite for identifying pathological immune signatures associated with inflammatory or autoimmune diseases.Here, 47 plasma cytokines, chemokines, and growth factors were quantified with a bead-based multiplex-assay (Merck HCYTA-60 K) using a FLEXMAP 3D™ instrument in 1175 individuals of the Study of Health in Pomerania (SHIP; TREND cohort, 532 men and 643 women, age: 20 to 81, BMI: 17.7 to 53.6). Associations of cytokine concentrations with age, sex, BMI, season, and blood cell parameters (BCP) were examined by multivariate regression models.The physiological cytokine concentrations differed strongly between analytes, with median concentrations ranging from 0.6 to 7820 pg/mL. [...]

A full understanding of how we see our world remains a fundamental research question in vision neuroscience. While topographic profiling has allowed us to identify different visual areas, the exact functional characteristics and organization of areas up in the visual hierarchy (beyond V1 & V2) is still debated. [...]

Pathogenic mutations within the TBK1 gene leading to haploinsufficiency are causative of amyotrophic lateral sclerosis (ALS). This gene is linked to autophagy and inflammation, two cellular mechanisms reported to be dysregulated in ALS patients, although its functional role in the pathogenesis could involve other players. [...]

Individuals with obsessive-compulsive disorder (OCD) face both personal and system-based barriers in receiving first-line treatment, i.e. cognitive behavioral therapy (CBT) with exposure and response prevention (ERP). [...]

Multiple biomolecular condensates coexist at the pre- and post- synapse to enable vesicle dynamics and controlled neurotransmitter release in the brain. In pre-synapses, intrinsically disordered regions (IDRs) of synaptic proteins are drivers of condensation that enable clustering of synaptic vesicles (SVs). [...]