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Introduction: The growing number of elderly people in the populationis accompanied by an increased prevalence of chronic diseases, e.g.dementia, which will confront the healthcare system with majorchallenges in the future. Therefore, appropriate interventions are neededto support healthy aging combined with a high quality of life. [...]

Stroke is the second leading cause of death (after heart disease) and a major cause of disability worldwide. Also called a brain attack, typical symptoms of stroke include sudden one-sided weakness and numbness in the face and arm as well as altered speech. [...]

Accurate prediction of progression in subjects at risk of Alzheimer's disease is crucial for enrolling the right subjects in clinical trials. However, a prospective comparison of state-of-the-art algorithms for predicting disease onset and progression is currently lacking. [...]

White matter alterations are increasingly implicated in neurological diseases and their progression. International-scale studies use diffusion-weighted magnetic resonance imaging (DW-MRI) to qualitatively identify changes in white matter microstructure and connectivity [...]

Background: There are currently no sex-specific recommendations for antipsychotic prescribing in schizophrenia, although women may be more susceptible to certain side-effects and may require lower doses to achieve comparable efficacy to men. However, sex differences remain insufficiently studied to inform treatment decisions.Methods: We plan a systematic review and individual-participant-data meta-analysis of randomized trials comparing different antipsychotic drugs, doses, formulations with each other or with placebo in adults with acute schizophrenia. [...]

The relationship between sleep disorders and neurodegeneration is complex. Using >1 million electronic health records from Wales, UK, and Finland, we mined biobank data to identify relationships between sleep disorders and neurodegenerative diseases (NDDs). [...]

Early perfusion amyloid-PET imaging is emerging as a valuable tool to potentially capture patients’ neurodegeneration patterns, allowing same-day, same-tracer categorization of both amyloidosis (A) and neurodegeneration (N) biomarkers. Early perfusion amyloid-PET might provide an added value for differential diagnosis and, in keeping with the capability of FDG-PET to indirectly track co-pathology in AD patients, it may complement the information provided by amyloid PET thus supporting a more accurate weighting of the different underlying pathological processes. [...]

Die Deutsche Gesellschaft für Neurologie (DGN) möchte die strukturierte Weiterbildung im gesamten Bereich neuroimmunologischer Erkrankungen und damit die Sicherung der Qualität ärztlicher Berufsausübung in diesem wachsenden Feld sicherstellen. Daher hat sie ihre Klinische Kommission „Neuroimmunologie“ damit beauftragt, entsprechend der Musterweiterbildungsordnung (MWBO) der Bundesärztekammer (BÄK) einen Entwurf für einen „Schwerpunkt Neuroimmunologie“ zu erarbeiten. [...]

While inhibition of terminal complement activation is an effective therapeutic strategy in acetylcholine receptor antibody-positive generalized myasthenia gravis (AChR-Ab+ gMG) and aquaporin‑4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-Ab+ NMOSD), it is associated with an increased risk for invasive meningococcal infection. As such, all patients receiving complement inhibitors—including eculizumab, ravulizumab, and zilucoplan—require vaccination against meningococcal serogroups A, C, W, Y (MenACWY) and B (MenB). [...]