Full Text Collection

Latest additions:
2024-06-06
09:25
OpenAccess [DZNE-2024-00736] Journal Article
; ; ; et al
Systematic evaluation of fMRI data-processing pipelines for consistent functional connectomics.
Functional interactions between brain regions can be viewed as a network, enabling neuroscientists to investigate brain function through network science. Here, we systematically evaluate 768 data-processing pipelines for network reconstruction from resting-state functional MRI, evaluating the effect of brain parcellation, connectivity definition, and global signal regression. [...]
OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);

Detailed record - Similar records
2024-05-27
09:51
OpenAccess [DZNE-2024-00617] Journal Article
; ; ; et al
A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli.
Science advances 10(21), eadj8769 () [10.1126/sciadv.adj8769]
Circular RNAs (circRNAs) are a large class of noncoding RNAs. Despite the identification of thousands of circular transcripts, the biological significance of most of them remains unexplored, partly because of the lack of effective methods for generating loss-of-function animal models. [...]
OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);

Detailed record - Similar records
2024-05-23
16:07

Detailed record - Similar records
2024-05-22
16:31
OpenAccess [DZNE-2024-00600] Journal Article
; ; ; et al
Sex-specific cortical, hippocampal and thalamic whole genome transcriptome data from controls and a G72 schizophrenia mouse model.
The G72 mouse model of schizophrenia represents a well-known model that was generated to meet the main translational criteria of isomorphism, homology and predictability of schizophrenia to a maximum extent. In order to get a more detailed view of the complex etiopathogenesis of schizophrenia, whole genome transcriptome studies turn out to be indispensable. [...]
OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);

Detailed record - Similar records
2024-05-21
10:51
OpenAccess [DZNE-2024-00597] Journal Article
; ; ; et al
Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results.
Alzheimer's and dementia 20(5), 3525 - 3542 () [10.1002/alz.13750]
Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD). We investigate the utility of cerebral perfusion as one such biomarker in presymptomatic FTD mutation carriers.We investigated longitudinal profiles of cerebral perfusion using arterial spin labeling magnetic resonance imaging in 42 C9orf72, 70 GRN, and 31 MAPT presymptomatic carriers and 158 non-carrier controls. [...]
OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);

Detailed record - Similar records
2024-05-21
10:46
OpenAccess [DZNE-2024-00596] Journal Article
; ; ; et al
Inverted U-shape-like functional connectivity alterations in cognitive resting-state networks depending on exercise intensity: An fMRI study.
Acute physical activity influences cognitive performance. However, the relationship between exercise intensity, neural network activity, and cognitive performance remains poorly understood. [...]

Detailed record - Similar records
2024-05-21
10:42
OpenAccess [DZNE-2024-00595] Journal Article
; ; ; et al
Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study.
Alzheimer's and dementia 20(5), 3429 - 3441 () [10.1002/alz.13761]
To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations.A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid-PET were included. A normative strategy was used to define reliable accumulation by estimating the 95th percentile of longitudinal measurements in sub-populations (NPNHS = 101/750, NInsight46 = 35/382) expected to remain stable over time. [...]

Detailed record - Similar records
2024-05-21
10:40
OpenAccess [DZNE-2024-00594] Journal Article
; ; ; et al
Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium.
Alzheimer's and dementia 20(5), 3270 - 3280 () [10.1002/alz.13779]
People with Down syndrome (DS) have high risk of developing Alzheimer's disease (AD). This study examined mean ages of AD diagnosis and associations with co-occurring conditions among adults with DS from five European countries.Data from 1335 people with DS from the Horizon 21 European DS Consortium were used for the analysis.Mean ages of AD diagnosis ranged between 51.4 (SD 7.0) years (United Kingdom) and 55.6 (SD 6.8) years (France). [...]

Detailed record - Similar records
2024-05-21
10:39
OpenAccess [DZNE-2024-00593] Journal Article
; ; ; et al
Adapting prescribing criteria for amyloid-targeted antibodies for adults with Down syndrome.
Alzheimer's and dementia 20(5), 3649 - 3656 () [10.1002/alz.13778]
Prior authorization criteria for Federal Drug Administration (FDA) approved immunotherapeutics, among the class of anti-amyloid monoclonal antibodies (mAbs), established by state drug formulary committees, are tailored for adults with late-onset Alzheimer's disease. This overlooks adults with Down syndrome (DS), who often experience dementia at a younger age and with different diagnostic assessment outcomes. [...]

Detailed record - Similar records
2024-05-21
10:31
OpenAccess [DZNE-2024-00592] Journal Article
; ; ; et al
Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression.
The presence of mesenchymal stem cells has been confirmed in some solid tumors where they serve as important components of the tumor microenvironment; however, their role in cancer has not been fully elucidated. The aim of this study was to investigate the functions of mesenchymal stem cells isolated from tumor tissues of patients with non-small cell lung cancer.Human lung cancer-derived mesenchymal stem cells displayed the typical morphology and immunophenotype of mesenchymal stem cells; they were nontumorigenic and capable of undergoing multipotent differentiation. [...]
OpenAccess: Download fulltextPDF Download fulltextPDF (PDFA);

Detailed record - Similar records