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2024-10-10
09:49
OpenAccess [DZNE-2024-01196] Preprint
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Heterogeneous plasticity of amygdala interneurons in associative learning and extinction
Neural circuits undergo experience-dependent plasticity to form long-lasting memories. Excitatory projection neurons are considered to be the primary neuronal substrate for memory acquisition and storage. [...]
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2024-10-10
09:43
OpenAccess [DZNE-2024-01195] Preprint
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Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice
The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation of output generation. Recent studies shedding light on AIS function used predominantly post hoc approaches since no robust murine in vivo live reporters exist. [...]
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2024-10-01
11:04
OpenAccess [DZNE-2024-01179] Journal Article
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Rapid submillimeter QSM and R2* mapping using interleaved multishot 3D-EPI at 7 and 3 Tesla
Magnetic resonance in medicine 92(6), 2294 - 2311 () [10.1002/mrm.30216]
Purpose: To explore the high signal-to-noise ratio (SNR) efficiency of interleaved multishot 3D-EPI with standard image reconstruction for fast and robust high-resolution whole-brain quantitative susceptibility (QSM) and R2* mapping at 7 and 3T.Methods: Single- and multi-TE segmented 3D-EPI is combined with conventional CAIPIRINHA undersampling for up to 72-fold effective gradient echo (GRE) imaging acceleration. Across multiple averages, scan parameters are varied (e.g., dual-polarity frequency-encoding) to additionally correct for B0-induced artifacts, geometric distortions and motion retrospectively. [...]
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2024-10-01
10:31
OpenAccess [DZNE-2024-01178] Journal Article
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Design requirements for human UHF magnets from the perspective of MRI scientists
The highest magnetic field strength for human-sized magnetic resonance imaging (MRI) currently lies at 11.7 tesla. Given the opportunities for enhanced sensitivity and improved data quality at higher static magnetic fields, several initiatives around the world are pursuing the implementation of further human MRI systems at or above 11.7 tesla. [...]
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2024-10-01
10:05
OpenAccess [DZNE-2024-01173] Journal Article
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Beyond Nyquist: A Comparative Analysis of 3D Deep Learning Models Enhancing MRI Resolution.
High-spatial resolution MRI produces abundant structural information, enabling highly accurate clinical diagnosis and image-guided therapeutics. However, the acquisition of high-spatial resolution MRI data typically can come at the expense of less spatial coverage, lower signal-to-noise ratio (SNR), and longer scan time due to physical, physiological and hardware limitations. [...]
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2024-10-01
10:03
OpenAccess [DZNE-2024-01172] Journal Article
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Improved gradient echo magnitude- and phase-based mapping of T2 using multiple RF spoiling increments at 3T and 7T.
Magnetic resonance in medicine 92(6), 2328 - 2342 () [10.1002/mrm.30217]
The transverse relaxation time T2 holds significant relevance in clinical applications and research studies. Conventional T2 mapping approaches rely on spin-echo sequences, which require lengthy acquisition times and involve high radiofrequency (RF) power deposition. [...]
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2024-10-01
09:56
OpenAccess [DZNE-2024-01171] Journal Article
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Differential Psychological Treatment Effects in Patients With Late-Life Depression and a History of Childhood Maltreatment.
This is the first interventional study to assess the impact of childhood maltreatment (CM) on psychological treatment outcomes in patients with late-life depression (LLD).This is a secondary analysis of a multicenter, randomized controlled trial with 251 participants aged ≥60 years with moderate to severe depression. Participants were randomly assigned to cognitive behavioral therapy for late life depression (LLD-CBT) or to a supportive intervention (SUI). [...]
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2024-09-27
15:27
OpenAccess [DZNE-2024-01169] Journal Article
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Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation.
Cell reports 43(9), 114736 () [10.1016/j.celrep.2024.114736]
Short-chain fatty acids (SCFAs) are immunomodulatory compounds produced by the microbiome through dietary fiber fermentation. Although generally considered beneficial for gut health, patients suffering from inflammatory bowel disease (IBD) display poor tolerance to fiber-rich diets, suggesting that SCFAs may have contrary effects under inflammatory conditions. [...]
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2024-09-27
15:21
OpenAccess [DZNE-2024-01168] Journal Article
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Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes.
Neuron 112(18), 3106 - 3125.e8 () [10.1016/j.neuron.2024.06.029]
Microglia are crucial for maintaining brain health and neuron function. Here, we report that microglia establish connections with neurons using tunneling nanotubes (TNTs) in both physiological and pathological conditions. [...]
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2024-09-27
09:36
OpenAccess [DZNE-2024-01166] Journal Article
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Hippocampal-occipital connectivity reflects autobiographical memory deficits in aphantasia
eLife 13, RP94916 () [10.7554/eLife.94916]
Aphantasia refers to reduced or absent visual imagery. While most of us can readily recall decade-old personal experiences (autobiographical memories, AM) with vivid mental images, there is a dearth of information about whether the loss of visual imagery in aphantasics affects their AM retrieval. [...]
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