OpenAccess

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2022-06-15
12:10
OpenAccess [DZNE-2022-01203] Journal Article
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Multi-Round Trust Game Quantifies Inter-Individual Differences in Social Exchange from Adolescence to Adulthood
Computational psychiatry 5(1), 102 - 118 () [10.5334/cpsy.65]
Investing in strangers in a socio-economic exchange is risky, as we may be uncertain whether they will reciprocate. Nevertheless, the potential rewards for cooperating can be great. [...]
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2022-06-15
12:08
OpenAccess [DZNE-2022-01202] Journal Article
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Extending the applicability of P3D for structure determination of small molecules
The application of anisotropic nuclear magnetic resonance (NMR) parameters for the correct structural assignment of small molecules requires the use of partially ordered media. Previously we demonstrated that the use of P3D simulations using poly(γ-benzyl-L-glutamate) (PBLG) as an alignment medium allows for the determination of the correct diastereomer from extremely sparse NMR data. [...]
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2022-06-15
12:05
OpenAccess [DZNE-2022-01201] Journal Article
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Deletion of the Autism-Associated Protein SHANK3 Abolishes Structural Synaptic Plasticity after Brain Trauma
International journal of molecular sciences 23(11), 6081 () [10.3390/ijms23116081] special issue: "Non-genetic Modifiers of Synaptic Plasticity and Neurotransmission in the Central Nervous System (CNS) in Health and Disease"
Autism spectrum disorders (ASDs) are characterized by repetitive behaviors and impairments of sociability and communication. About 1% of ASD cases are caused by mutations of SHANK3, a major scaffolding protein of the postsynaptic density [...]
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2022-06-15
12:03
OpenAccess [DZNE-2022-01200] Journal Article
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Mitochondrial Dysfunction in Spinocerebellar Ataxia Type 3 Is Linked to VDAC1 Deubiquitination
International journal of molecular sciences 23(11), 5933 () [10.3390/ijms23115933] special issue: "Mitochondrial Function in Neurodegenerative Diseases"
Dysfunctional mitochondria are linked to several neurodegenerative diseases. Metabolic defects, a symptom which can result from dysfunctional mitochondria, are also present in spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease, the most frequent, dominantly inherited neurodegenerative ataxia worldwide [...]
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2022-06-15
12:01
OpenAccess [DZNE-2022-01199] Journal Article
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Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer’s Disease
Cells 11(11), 1807 () [10.3390/cells11111807] special issue: "Neurogenesis and Regeneration in Teleost Central Nervous System"
Neurogenesis is significantly reduced in Alzheimer’s disease (AD) and is a potential therapeutic target. Contrary to humans, a zebrafish can regenerate its diseased brain, and thus is ideal for studying neurogenesis [...]
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2022-06-15
11:58
OpenAccess [DZNE-2022-01198] Journal Article
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A Nuclear Belt Fastens on Neural Cell Fate
Cells 11(11), 1761 () [10.3390/cells11111761] special issue: "Concepts and Controversies in Adult Neurogenesis and Adult Neural Stem Cells"
Successful embryonic and adult neurogenesis require proliferating neural stem and progenitor cells that are intrinsically and extrinsically guided into a neuronal fate. In turn, migration of new-born neurons underlies the complex cytoarchitecture of the brain [...]
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2022-06-15
11:56
OpenAccess [DZNE-2022-01197] Journal Article
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Extracellular Inflammasome Particles Are Released After Marathon Running and Induce Proinflammatory Effects in Endothelial Cells
The intracellular NLRP3 inflammasome is an important regulator of sterile inflammation. Recent data suggest that inflammasome particles can be released into circulation. [...]
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2022-06-15
11:54
OpenAccess [DZNE-2022-01196] Journal Article
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Microvascular Impairment in Patients With Cerebral Small Vessel Disease Assessed With Arterial Spin Labeling Magnetic Resonance Imaging: A Pilot Study
In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. [...]
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2022-06-15
11:52
OpenAccess [DZNE-2022-01195] Journal Article
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α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
The protein α-synuclein, which is well-known for its links to Parkinson’s Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. [...]
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2022-06-15
11:37
OpenAccess [DZNE-2022-01192] Journal Article (Review Article)
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The Janus-like Association between Proton Pump Inhibitors and Dementia
Early pharmacoepidemiological studies suggested that Proton Pump Inhibitors (PPIs) might increase the risk of Alzheimer’s Disease (AD) and non-AD related dementias. These findings were supported by preclinical studies, specifically stressing the proamyloidogenic and indirect anticholinergic effects of PPIs. [...]
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