Full Text Collection

Weight loss, partially caused by hypermetabolism, represents a well-documented and therapeutically relevant feature of the amyotrophic lateral sclerosis phenotype worldwide. In this study, we retrospectively analysed the association between thyroid function and clinical, prognostic and metabolic parameters in a cohort of patients with amyotrophic lateral sclerosis in an experienced centre in Germany (n = 1754). [...]

BACKGROUND: Life expectancy for individuals with Down syndrome (DS) has significantly increased, primarily due to medical advances. While DS is considered a genetically determined form of Alzheimer’s disease (DS-AD), with neuropathological markers evident by age 40, the onset of clinical dementia varies. [...]

Attenuation correction is critical for accurate SPECT brain imaging and to quantify uptake ratios in neurological and psychiatric disorders. This prospective study aimed to validate the use of deep-learning-based magnetic resonance to synthetic computed tomography (DL-MRAC) attenuation correction by quantifying striatal and extrastriatal binding of [123I]I-FP-CIT to dopamine and serotonin transporters in Parkinson's disease patients.Synthetic CTs were generated from T1-weighted MRIs acquired in 12 Parkinson's disease patients using a validated 3D residual U-Net for attenuation correction of [123I]I-FP-CIT SPECT scans. [...]

Schizophrenia spectrum disorders (SSD) are associated with increased risks of criminal behavior, especially if mediated by factors such as substance use. However, it remains unclear whether these factors retain their predictive relevance once broader social and systemic conditions are considered. [...]

RNA binding proteins have multiple diverse cellular functions and are often mis-regulated in disease. Despite their many cellular functions and implications in disease, very little is known about their physiological functions. [...]

Synapses are the basic unit of information transfer between neurons. Their dysfunction is a common trigger of cognitive diseases and disorders. [...]

Introduction: Neural network effects of transcranial direct current stimulation (tDCS) are poorly understood. Here, we introduce a prospective, empirically informed, multimodal functional magnetic resonance imaging (fMRI) framework for guiding target selection and hypothesis-based analysis in future focal tDCS-fMRI studies.Methods: We illustrate our approach by using data of 37 healthy individuals (19 females; mean age ± SD = 25.8 ± 5.9) recruited from two tDCS-fMRI studies that were acquired at the same scanner and with placebo-tDCS. [...]

Background: Lewy Body pathology can be detected by alpha-synuclein-Seed Amplification Assay (αSyn-SAA) in cerebrospinal fluid (CSF) with high sensitivity and specificity in cohort studies. Yet, little is known about the results that can be expected from αSyn-SAA in CSF in samples outside cohort studies as obtained in clinical routine. [...]

During the progression of amyotrophic lateral sclerosis (ALS), only specific motor neurons (MNs) preferentially deteriorate, while others are spared until the disease reaches its end stage. Resilient MNs possess several protective factors, yet the precise molecular mechanism(s) underlying selective neuronal vulnerability remains poorly understood. [...]

Anti-seizure-related 6 homolog like 2 (SEZ6L2) antibodies are a rare cause of immune-mediated cerebellar syndromes. The clinical phenotype, diagnostic features, and outcomes have not been systematically synthesized, and the evidence is limited to case reports and case series. [...]