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Neural circuits undergo experience-dependent plasticity to form long-lasting memories, but how inhibitory interneurons contribute to this process remains poorly understood. Using miniature microscope calcium imaging, we monitored the activity of large amygdala interneuron populations in freely moving mice during fear learning and extinction. [...]

Childhood maltreatment is associated with an unhealthier lifestyle in adulthood and an increased risk of mental and somatic health problems, although the underlying pathways remain unclear. This study examined whether smoking and overweight mediate the association between childhood abuse/neglect and frequent adult diseases, including cancer, myocardial infarction, stroke, type 2 diabetes, chronic obstructive pulmonary disease, depression, and anxiety.Childhood maltreatment was assessed in 152,887 German National Cohort (NAKO) participants using the Childhood Trauma Screener. [...]

This edited volume addresses the environments that exacerbate, exclude, and stigmatise those living with dementia to explore designs and processes that can optimise well-being and independence.Featuring the voices and opinions of people with dementia, the chapters showcase individual homes, special dementia facilities, different forms of care homes, and public spaces, from landscape to urbanism, as examples of how to meet the needs and preferences for those living with dementia now. As a response to a recent Cochrane meta-analysis (2022) which highlighted the problems associated with using traditional, medically orientated evaluative methods for environmental design, this book demonstrates a range of research methods that can be used to inform and investigate good co-design of dementia-enabling environments. [...]

Lipid alterations in the brain have been implicated in many neurodegenerative diseases. To facilitate comparative lipidomic research across brain diseases, we establish a data common named the Neurolipid Atlas that we prepopulated with isogenic induced pluripotent stem cell (iPS cell)-derived lipidomics data for different brain diseases. [...]

The risk of developing Parkinson's disease (PD) is elevated in individuals with type 2 diabetes (T2DM), but the molecular pathways underlying this link remain unclear. Glycation, a non-enzymatic modification of lysine and arginine residues by reducing sugars or reactive dicarbonyls, may disrupt proteostasis and trigger pathology. [...]

INTRODUCTIONWith anti-amyloid beta (Aβ) therapies approved for Alzheimer's disease (AD), surrogate biomarkers are needed to monitor clinical treatment efficacy. Therefore, we systematically compared longitudinal changes in A/T/N biomarkers (amyloid-positron emission tomography [PET], tau-PET, plasma phosphorylated tau at threonine 217 [p-tau217], and magnetic resonance imaging) for tracking cognitive changes.METHODSWe analyzed longitudinal biomarker and cognitive change rates from the Alzheimer's Disease Neuroimaging Initiative (N = 141) and Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) (N = 151), estimated using linear mixed models. [...]

Autoimmune psychosis (AP) and other autoimmune psychiatric syndromes (APS) are associated with central nervous system antibodies. This study investigated related magnetic resonance spectroscopic imaging (MRSI) signatures and their correlations with electroencephalography (EEG), cerebrospinal fluid (CSF), and psychometric/neuropsychological measures.Twenty-eight adults with suspected antibody-positive AP spectrum syndromes were compared with 28 matched healthy controls. [...]

Following publication of the original article [1], the author reported that the below statement should be updated from.“Since the data was unbalanced in terms of inpatient palliative care cases, the synthetic minority over-sampling technique (SMOTE) was used to increase the number of cases to address this issue [18, 19].”to“Since the data was unbalanced in terms of inpatient palliative care cases, a minority over-sampling was done by random sampling with replacement to increase the number of cases to address this issue [1].”A new reference will also be added:1. William G. [...]

The existence of linear cholesterol-recognition motifs in transmembrane domains has long been debated. Evolutionary molecular dynamics (Evo-MD) simulations-genetic algorithms guided by (coarse-grained) molecular force-fields-reveal that thermodynamic optimal cholesterol attraction in isolated alpha-helical transmembrane domains occurs when multiple consecutive lysine/arginine residues flank a short hydrophobic segment. [...]

Rehabilitation is widely recognized as an essential component in evaluating the effectiveness of a therapeutic intervention in animal models of translational spinal cord injury research. Ideally, the rehabilitation method used should be optimized for the specific injury model and severity to adequately compare the efficacy of the investigational therapy. [...]