Journal Article

Motor fluctuations are a common and burdensome complication of Parkinson's disease (PD) when the disease progresses, largely driven by the short half-life and variable absorption of immediate-release (IR) levodopa. IPX203 is a next-generation modified-release levodopa/carbidopa formulation that delivers rapid onset and sustained plasma levodopa concentrations through IR granules and extended-release pellets. [...]

Humans select and learn goal-directed actions through the anticipation of their outcomes. While this ideomotor principle is well established in humans, its biological instantiation and relevance for organizing naturalistic behavior remain unclear, including its neurobiological substrates such as hippocampal plasticity. [...]

This procedure guideline for brain perfusion SPECT is intended to support the planning, execution, quality control, evaluation and reporting of brain perfusion SPECT studies using the 99 mTc-labelled radiopharmaceuticals [99 mTc]Tc-HMPAO and [99 mTc]Tc-ECD. It is an update and expansion built on the 2019 version of the procedure guideline. [...]

Gain-of-function variants in SCN2A, encoding the voltage-gated sodium channel NaV1.2, cause developmental and epileptic encephalopathies characterized by seizures, developmental delay, and white matter abnormalities. While NaV1.2 is known to regulate neuronal excitability, its role in oligodendroglial cells is unclear. [...]

Among the more than 90 identified genetic risk loci for late-onset Alzheimer's disease (AD) and related dementias, the apolipoprotein E (APOE) gene ɛ2/ɛ3/ɛ4 polymorphisms remain the longstanding benchmark for genetic disease risk with a consistently large effect across studies1-10. Despite this massive signal, the exact mechanisms by which ɛ4 increases and ɛ2 decreases dementia risk remain poorly understood. [...]

Acute stress prior to bedtime significantly alters the subsequent sleep. Although sleep is crucial for consolidating newly acquired memories, the impact of pre-sleep stress remains unclear. [...]

Mounting evidence suggests overlapping pathology across Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease (PD), yet its extent and clinical implications remain unclear.Cerebrospinal fluid (CSF) amyloid beta (Aβ)42/40, phosphorylated tau 181 (p-tau181), neurofilament light chain (NfL), and total α-synuclein were centrally measured using fully-automated Elecsys immunoassays in 347 participants (European Platform for Neurodegenerative Diseases [EPND] cohort) and compared between groups. Associations of amyloid and tau positivity with cognitive and motor function were evaluated.Compared to controls, amyloid and tau levels were abnormal in DLB, but not in PD. [...]

Tau pathology in Alzheimer's disease (AD) propagates along the brain's connectome, yet the mechanisms by which tau drives neuronal dysfunction remain unclear. We hypothesized that dysfunction primarily emerges in regions close to tau-harboring epicenters.One hundred thirty-one amyloid-positive individuals underwent dynamic [18F]PI-2620 tau positron emission tomography. [...]

Amyloid beta (Aβ) deposition and tau accumulation are neuropathological hallmarks of Alzheimer's disease (AD). While Aβ deposits present with a wide morphological variety, a comprehensive, cross-regional overview of Aβ plaque composition in AD and associations with clinicopathological traits are missing. [...]

Overlooked opportunities can help turn academic research into socioeconomic impact across Europe..