Journal Article

Previous studies have demonstrated strong links between circulating microRNAs (miRNA), lymphocytes, and immune markers suggesting that miRNAs are key regulators of immune function and immune related diseases. We used the population-based SHIP-TREND cohort (N = 804) to investigate how specific plasma-based miRNAs relate to lymphocytes, cardiometabolic diseases, and clinical parameters. [...]

Diagnostic MRI evaluation of temporal lobe epilepsy (TLE) depends on the subjective visual interpretation of MRI images. These interpretations could be enhanced by quantitative artificial intelligence (AI) support tools. [...]

Mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), remains undiagnosed in > 90% of individuals, delaying access to timely evaluation and interventions. Self-administered digital cognitive assessments (SA-DCAs) offer scalable approaches for early detection, yet their real-world validation and clinical readiness remain uncertain. [...]

T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells play critical roles in regulating the activity of the germinal center (GC), which is essential for the generation of high-affinity antibodies. In the GC, Tfh cells help B cells to proliferate and to differentiate into memory B cells and long-lived plasma cells. [...]

[18F]fluorodeprenyl-D2 ([18F]F-DED) positron emission tomography (PET) imaging detects reactive astrogliosis in patients with autoimmune encephalitis (AIE) and multiple system atrophy (MSA). Although dynamic 60-min acquisitions are established, shorter static imaging protocols are desirable for severely impaired patients. [...]

Sleep is multidimensional, and it remains unclear which aspects are most relevant to cognition and dementia risk. We aimed to apply a data-driven approach to identify clusters of sleep variables that reflect meaningful sleep composites and examined their association with cognition and dementia risk.This was a prospective observational cohort study that used data from the Sleep and Dementia Consortium, comprising 5 US population-based cohorts. [...]

To design and develop an 8-channel transmit 32-channel receive 11.7T head coil for the strongest human MRI scanner to date, demonstrate safety, and evaluate signal-to-noise ratio (SNR) gains compared to 7T, the most used ultra-high-field (UHF) platform.The transmit array design incorporated a folded-end radiofrequency (RF) shield to mitigate wave propagation in the scanner bore. The receive array consisted of 32-overlapped loops constructed on a helmet size-matched with the industry standard 7T head coil. [...]

To integrate MR-based servo navigation in MPRAGE and 3D-TSE sequences and demonstrate its potential for prospective head motion correction in structural imaging.Repeated modules of servo navigators were inserted before each preparation pulse of MPRAGE and 3D-TSE sequences (before-prep) for rapid convergence of motion parameter estimation. Additionally, reference navigators were distributed along the imaging echo train to test a within-echo train correction (within-ET) with contrast-matched models, enabling more frequent geometry updates. [...]

To demonstrate the synergy of undersampled radial 2in1-RARE-EPI acquisition and nonlinear model-based reconstruction for accelerated and simultaneous T2, T2*, and R2' mapping in brains of patients with multiple sclerosis (MS).2in1-RARE-EPI combines a RARE module with an EPI module to capture T2 and T2* information. Nonlinear model-based reconstruction was applied to estimate T2, T2* maps directly from undersampled k-space data. [...]

Clinical prognostication and decision-making in IDH-mutant glioma is increasingly complex, especially with new targeted treatment options like IDH-inhibitors. Individual patient risk stratification for better treatment planning is needed; however, standard prognostic models rely on clinical and histologic parameters as well as MRI, which may not fully reflect the tumor's biological behavior. [...]