Journal Article

Acute stress prior to bedtime significantly alters the subsequent sleep. Although sleep is crucial for consolidating newly acquired memories, the impact of pre-sleep stress remains unclear. [...]

Mounting evidence suggests overlapping pathology across Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease (PD), yet its extent and clinical implications remain unclear.Cerebrospinal fluid (CSF) amyloid beta (Aβ)42/40, phosphorylated tau 181 (p-tau181), neurofilament light chain (NfL), and total α-synuclein were centrally measured using fully-automated Elecsys immunoassays in 347 participants (European Platform for Neurodegenerative Diseases [EPND] cohort) and compared between groups. Associations of amyloid and tau positivity with cognitive and motor function were evaluated.Compared to controls, amyloid and tau levels were abnormal in DLB, but not in PD. [...]

Tau pathology in Alzheimer's disease (AD) propagates along the brain's connectome, yet the mechanisms by which tau drives neuronal dysfunction remain unclear. We hypothesized that dysfunction primarily emerges in regions close to tau-harboring epicenters.One hundred thirty-one amyloid-positive individuals underwent dynamic [18F]PI-2620 tau positron emission tomography. [...]

Amyloid beta (Aβ) deposition and tau accumulation are neuropathological hallmarks of Alzheimer's disease (AD). While Aβ deposits present with a wide morphological variety, a comprehensive, cross-regional overview of Aβ plaque composition in AD and associations with clinicopathological traits are missing. [...]

Overlooked opportunities can help turn academic research into socioeconomic impact across Europe..

Aim: Neurological symptoms, including cognitive complaints and fatigue, are common in post-COVID-19 Condition (PCC), a complex multisystem disorder following SARS-CoV-2 infection. Although gut microbiota changes have been reported in PCC and linked to PCC-associated neurological manifestations, its relationship to structural or functional brain changes remains unexplored. [...]

People with Down Syndrome (DS) show deficits in executive functions (EF), yet their development across the lifespan remains poorly characterized. Central questions, whether EF improves into adulthood, peaks or plateaus, and when decline begins, have been difficult to answer due to small, heterogeneous, and mostly cross-sectional studies. [...]

Sleep disturbances are highly prevalent and associated with greater psychological symptom burden in patients with implantable cardioverter-defibrillators (ICDs), yet the multidimensional nature of sleep disturbance in this population remains insufficiently characterized.This study aimed to (1) identify distinct sleep patterns in patients with an ICD using the seven Pittsburgh Sleep Quality Index (PSQI) component scores, (2) examine sociodemographic and clinical predictors of sleep-profile membership, and (3) assess associations between sleep profiles and symptom burden of posttraumatic stress, anxiety, and depression.Sleep profiles were derived from PSQI component scores using latent profile analysis (LPA). Sociodemographic and clinical determinants of profile membership were evaluated using multinomial logistic regression. [...]

The cGAS–STING pathway is a central mediator of antiviral immunity, yet its constitutive activation causes severe systemic autoinflammatory disease and neurodegeneration. Intermittent fasting (IF) has been proposed as a non-pharmacological strategy to attenuate inflammation and neurodegeneration. [...]

Animals rely on neural representations of sensory stimuli to rapidly recognize familiar environments and precisely identify salient cues. In the Drosophila mushroom body, odors are represented by the activity of Kenyon cells (KCs), whose random wiring with olfactory projection neurons (PNs) is generally thought to promote odor discrimination. [...]