Journal Article

Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal phase of Lewy body diseases and linked to a high risk for cognitive decline. Therefore, iRBD provides a suitable window for early intervention.In the monocentric randomized controlled trial 'Cognitive Training & a Healthy, Active Lifestyle Program for People with Isolated REM Sleep Behaviour Disorder' (CogTrAiL-RBD), the feasibility and behavioral effects of a 5-week digital, adaptive, multidomain cognitive training alongside a module promoting a healthy lifestyle (INT) were compared to a waiting-list control group (CON) in 82 individuals with polysomnography-confirmed iRBD. [...]

We examined whether locus coeruleus (LC) contrast, an indirect proxy for neuronal density and structural health, was related to delayed episodic memory in healthy older adults (OAs) and those with mild cognitive impairment (MCI) and its association with encoding-related brain activity, controlling for emotional salience.Participants (27 younger adults, 26 OAs, and 24 MCI) memorized emotional and neutral images during functional magnetic resonance imaging (MRI). Delayed memory was tested after 4 h and compared to immediate memory. [...]

Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive, fatal neurodegenerative disease. Patients with ALS are at increased risk of developing depressive symptoms. [...]

[This corrects the article DOI: 10.3389/fnsyn.2026.1832103.]..

Individuals with autosomal dominant frontotemporal dementia (FTD) exhibit considerable variability in disease onset and progression. Both modifiable and non-modifiable factors-such as sex, educational attainment or geographic region of residence-may contribute to this heterogeneity, potentially through their influence on cognitive reserve. [...]

Background: Normal aging is accompanied by cognitive decline, structural and functional brain changes. Cognitive training is a potentially effective intervention for cognitive improvement. [...]

Tobacco use is one of the major threats to public health on a global scale. Smokeless Tobacco (SLT) poses a significant risk for oral cancer and has other adverse health outcomes in women. [...]

Astrocyte loss occurs in various neurological conditions and can disrupt local tissue homeostasis. While astrocytes surrounding border-forming lesions adopt reactive states without restoring astrocyte networks, how astrocytes respond to spatially confined astrocyte loss remains poorly understood. [...]

TDP-43 proteinopathy is a hallmark of neurodegenerative disorders such as amyotrophic lateral sclerosis and frontotemporal dementia where mislocalization of TDP-43 has been observed in neurons and glial cells. However, the role of TDP-43 in microglia and the consequences of its loss of function remain unexplored. [...]