Journal Article

[This corrects the article DOI: 10.3389/fdgth.2026.1814015.]..

Accurate visualization of glioblastoma is essential for guiding biopsy, resection and radiotherapy. Contrast-enhanced MRI is routine in clinical practice, yet it can miss metabolically active tumor outside areas of blood-brain barrier disruption. [...]

To compare a '7-DAY' and 'TODAY' recall period of the EQ-HWB-9 in people living with dementia (PlwD) with regard to day-to-day health changes (health fluctuations) and recall period adherence.In this mixed-methods study, PlwD-caregiver dyads from German primary care were randomized to complete the EQ-HWB-9 (self- and proxy-proxy report) using either a '7-day' or 'today' recall period over a two-week time period on day 1, day seven and day 14. In addition, caregivers recorded daily health fluctuations over 14 days via a diary. [...]

Germany has a longstanding tradition of excellence in neuroscience and Parkinson's research, supported by outstanding academic institutions, specialized clinical centers, and a strong scientific community. Building on this strong foundation, the country now has the opportunity to transform its clinical research landscape into a more integrated ecosystem for Parkinson syndromes. [...]

COMT inhibitors (COMT-Is) have now been established for thirty years as adjunctive medication in the treatment of Parkinson's disease (PD). When they were first introduced, the prolonged duration of action of levodopa and the increase in levodopa levels were regarded as significant advances. [...]

In addition to response fluctuations caused by the pharmacokinetics of dopamine replacement medication, temporal variation in the expression and severity of motor and non-motor symptoms, which is not or only partially attributable to the effects of the medication, are also common in Parkinson's disease (PD). The spectrum of transient changes of motor symptom expression unrelated to the classical ON-OFF fluctuations ranges from brief episodes of gait freezing or tremor breakthroughs to severe akinetic crisis and non-motor phenomena include discontinuous changes in cognition and vigilance. [...]

Parkinson's disease (PD) is the fastest growing neurological disorder worldwide and is projected to affect unprecedented numbers of individuals by 2050. At the same time, PD research is undergoing a profound conceptual transformation. [...]

Multiple system atrophy (MSA) is a rare and rapidly progressive neurodegenerative disorder characterized by a variable combination of autonomic failure, parkinsonism, and cerebellar ataxia, with a median survival of 8-10 years from symptom onset. Its aetiology remains poorly understood, as most cases are sporadic and environmental contributors remain unclear. [...]

The digital transformation of healthcare is rapidly reshaping neurology, particularly in the field of movement disorders, where continuous monitoring, long disease trajectories, and complex multimodal care create a high demand for innovative solutions. Wearable sensors, digital diagnostics, app-based therapeutics, and integrated hybrid care networks and digital supported care pathways promise earlier diagnosis, personalized treatment and care management, and improved long-term outcomes. [...]

Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories relate to one another. [...]