Journal Article

To evaluate associations between respiratory support strategies, partial pressure of carbon dioxide (pCO2) variability and oxygen exposure in neonates with hypoxic-ischaemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH).This retrospective multicentre study used data from the German Hypothermia Registry, including neonates ≥ 36 weeks with moderate-to-severe HIE treated with TH between 2022 and 2025. Respiratory support was categorized as continuous positive airway pressure (CPAP) or invasive ventilation. [...]

To improve signal strength and homogeneity of whole-brain diffusion-weighted imaging (DWI) at 7T.Universal multiband excitation and refocusing pulses were optimized with the gradient ascent pulse engineering (GRAPE) algorithm across a database of B 1 + and B 0 maps obtained from 20 subjects. Slice-selective multiband pulses were optimized in a two-step optimization for transverse and sagittal slice orientations. [...]

Prion diseases are inevitably fatal, rare, and infectious neurodegenerative diseases of humans and animals. Initially, they were thought to be caused by unconventional slow viruses, and early research therefore relied heavily on experimental approaches used in virology. [...]

Artificial intelligence (AI) is expected to become increasingly important in hospitals and clinical care. However, successful implementation depends on technical, organizational, and user-related factors. [...]

The ability to remember where objects are located is a fundamental cognitive function particularly vulnerable to aging and neurodegenerative disease. Previous functional magnetic resonance imaging (fMRI) research has combined object-location memory (OLM) with broader spatial memory and navigation tasks, resulting in inconsistent findings. [...]

BackgroundSubjective cognitive decline (SCD) is recognized as an early indicator of preclinical Alzheimer's disease (AD). However, individuals with SCD do not exhibit cognitive impairment on standard neuropsychological tests. [...]

The transcription factor TATA-box-binding protein (TBP) plays a crucial role in neurons, as highlighted by its involvement in spinocerebellar ataxia type 17 (SCA17), where pathological polyglutamine expansions disrupt its function. While the molecular pathomechanisms remain unclear, our previous study showed that calcium-activated calpains cleave TBP in SCA17 cell and animal models. [...]

Unilateral peripheral vestibular loss induces adaptive mechanisms of cerebral plasticity. The quantified Ginkgo biloba extract EGb 761® has been shown to enhance neural plasticity, and is used in the treatment of vertigo and dizziness. [...]

[This corrects the article DOI: 10.3389/fdgth.2026.1814015.]..

Accurate visualization of glioblastoma is essential for guiding biopsy, resection and radiotherapy. Contrast-enhanced MRI is routine in clinical practice, yet it can miss metabolically active tumor outside areas of blood-brain barrier disruption. [...]