Journal Article

The READISCA study aims to prepare for clinical trials in spinocerebellar ataxia types 1 and 3 (SCA1 and SCA3). Hence, we searched for predictive variables of ataxia onset (phenoconversion) and progression. [...]

Cognitive aging is a highly heterogeneous process, with some individuals preserving stable cognitive performance across the lifespan while others exhibiting pronounced decline. This marked interindividual variability indicates that chronological age alone is a poor predictor of cognitive health. [...]

Grid cells in the human entorhinal cortex (EC) play a critical role in spatial navigation and memory. The EC is also one of the first regions affected by ageing and Alzheimer’s disease. [...]

Inhibitory interneuron diversity is a central feature of cortical circuits. The IN-CODE consortium seeks to combine large-scale recordings of interneuron types with machine-learning tools to identify the role of their physiological features, connectivity motifs, and cooperativity in cognitive functions..

Glioblastoma (GBM) remains the most prevalent and aggressive primary central nervous system (CNS) malignancy; however, the clinical efficacy of the preferred chemotherapeutic agent, Temozolomide (TMZ), is severely compromised by innate and acquired resistance. Sphingolipid metabolism acts as a pivotal regulator of GBM cell fate, and the imbalance of the 'sphingolipid rheostat' is intimately linked to TMZ resistance. [...]

Emerging evidence suggests a role of neuronal autoantibodies (nAbs) for long-term stroke outcomes. However, data remain limited and many domains unexamined. [...]

The brain and heart constantly communicate with each other to adapt to changes in the environment. In recent years, we have seen increasing recognition that brain-heart interactions influence many cognitive and behavioural functions, and that disturbances in this bidirectional relationship can have detrimental effects on both organs. [...]

Magnetic resonance-guided focused ultrasound (MRgFUS) is a promising, noninvasive therapeutic approach for essential tremor (ET), yet the effects of the respective lesions on functional brain network organization remain poorly understood. Here, we performed graph theory analysis to investigate changes in small-world properties and modular architecture in ET patients six months after unilateral MRgFUS of the thalamic ventral intermediate (VIM) nucleus. [...]

Extend the universal pulse GRAPE formalism to pulses with a defined spectral response, and apply the concept to spatial selection.We added Bloch simulations at several frequencies for each voxel to the pulse calculation to create universal spectrally-selective GRAPE pulses. With a superimposed constant gradient field spatial selection was achieved. [...]

A modified interleaved flyback (miFB) approach is introduced, designed to mitigate flow artifacts caused by alternating readout polarities in Echo Planar Imaging (EPI), while preserving acquisition efficiency.We propose reconstructing odd and even echoes of 3D-EPI separately. To this end, the respective missing lines are acquired in interleaved shots with inverted polarity and an additional gradient pre-lobe. [...]