Journal Article

TIA-1 (T-cell intracellular antigen 1) is an RNA-binding protein central to the formation of stress granules (SGs) and modulation of inflammatory responses. Recent research has identified TIA-1 as a key player in neurodegenerative diseases, especially those involving Tau pathology such as in Alzheimer’s disease (AD), in a subtype-dependent manner. [...]

The brain is man’s second-fattiest organ and shows a remarkable lipid diversity. Despite recent advances in lipidomics, much remains unknown about the connection between blood lipids and the brain. [...]

Low physical activity (PA) and poor cognitive function are associated with higher mortality risks. However, little is known about their interaction, including whether PA may moderate cognition-related mortality risks. [...]

Monoclonal antibodies targeting amyloid-β are the first approved disease-modifying treatment for Alzheimer’s disease. While amyloid-targeting therapies mitigate the progression of cognitive decline in early-stage Alzheimer’s disease, they are associated with amyloid-related imaging abnormalities (ARIA), an imaging phenomenon presenting as cerebral edema/effusion and/or hemorrhage. [...]

Synucleinopathies, including Parkinson's disease, involve α-synuclein (SNCA) accumulation and neurodegeneration, but early molecular effects of increased SNCA dosage remain incompletely defined. We examined human midbrain organoids derived from induced pluripotent stem cells carrying SNCA triplication and an isogenic control to assess early alterations in a 3D human model. [...]

Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by motor and non-motor symptoms. Early diagnosis remains challenging due to the lack of reliable, non-invasive biomarkers. [...]

Parkinson's disease (PD) is the fastest growing neurological disorder worldwide and, together with other movement disorders, belongs to a group of chronic neurological conditions associated with a substantial burden for affected individuals, caregivers, and healthcare systems. Despite significant advances in symptomatic treatment, disease-modifying therapies remain unavailable, shifting increasing attention toward prevention as a key therapeutic strategy. [...]

Leigh syndrome (Leigh) is an untreatable mitochondrial disorder characterized by lactic acidosis and basal ganglia and midbrain pathology, leading to psychomotor regression and early death. We previously uncovered impaired neuronal morphogenesis in Leigh cerebral organoids carrying SURF1 gene variants. [...]

This study employed diffusion kurtosis imaging (DKI) and proton magnetic resonance spectroscopy (1H-MRS) on an MPTP-induced mouse model of Parkinson's disease (PD) to examine microstructural changes linked to neuroinflammation and neurodegeneration.MPTP (20 mg/kg, i.p.) was given for 4 days, and behavioral assessment, MRI imaging, and immunohistochemistry were performed at 24 h and 72 h after last MPTP treatment.At 24 h, DKI showed higher diffusivity metrics in the hippocampus and thalamus, while 1H-MRS identified reduced Glu/tCr and Glx/tCr ratios in the striatum of MPTP-treated mice compared to saline-treated mice. Behavioral tests at 72 h revealed motor impairment and DKI showed increased diffusivity in the somatosensory cortex, thalamus, and striatum in MPTP-treated mice. [...]