Journal Article

Background: Health-related factors may influence blood-based biomarkers (BBBM) of Alzheimer's disease (AD). In this analysis, associations between modifiable factors and plasma biomarkers of neurodegeneration were investigated across the Alzheimer's disease spectrum and in cognitively healthy controls in a cerebrospinal fluid–confirmed (CSF) cohort. [...]

Autobiographical memory (AM) and imagination both rely on the brain's ability to construct vivid, coherent mental representations of past or imagined experiences. A central cognitive process underlying these functions is scene construction-the mental generation of spatially organized, imagery-rich representations of environments. [...]

Artificial intelligence (AI) has vast potential to reshape nuclear medicine. Applications can be found at every step of the processing workflow, including image acquisition, image reconstruction, enhancement, and registration, segmentation, extraction of image-derived biomarkers, and prognostication, both for clinical and preclinical research and routine use. [...]

For nearly 150 years, textbooks have described dendritic morphology as optimized for efficient synaptic voltage transfer from spines to the soma, implemented as a tubular design respecting Rall's 3/2 rule for impedance matching at branch points. Here, we reveal that this view is an oversimplification. [...]

Magnetic resonance imaging is the modality of choice for noninvasive temperature mapping to monitor and also to control hyperthermia. Temperature rise is observed through the proton resonance frequency shift (PRFS) reflecting in the phase of gradient echo acquisitions. [...]

Artificial intelligence (AI) has not seen the clinical uptake that might be expected from a technology that has received so much attention and investment. Coupled to neuroimaging, it is conceivable that AI algorithms can provide better performance in diagnosis and prognosis as well as optimize treatments in a precision medicine regimen, all of which is focused on improving both the patient experience and clinical outcomes. [...]

Despite established clinical diagnostic criteria for Parkinson's disease and the neurodegeneration-related atypical parkinsonian syndromes (progressive supranuclear palsy/PSP, corticobasal degeneration syndrome/CBD, multiple system atrophy with parkinsonian or cerebellar predominance/MSA-P/C, and dementia with Lewy bodies/DLB), the differential diagnosis from rare hereditary and acquired disorders presenting with parkinsonism can be challenging.Based on a PubMed search, relevant original studies and review articles were analyzed to identify rare hereditary and acquired disorders associated with parkinsonism. Secondary parkinsonian syndromes resulting from medication or toxin exposure were excluded but are summarized in an overview.Without claiming completeness, the major hereditary and acquired disorders associated with parkinsonism were summarized in tabular form. [...]

Die Demenz mit Lewy-Körperchen (DLB) ist nach der Alzheimer-Demenz die zweithäufigste neurodegenerative Demenzform und zählt zu den atypischen Parkinson-Syndromen. Sie ist charakterisiert durch kognitive Fluktuationen, visuelle Halluzinationen, eine REM-Schlaf-Verhaltensstörung und Parkinson-Symptome. [...]

Functional connectivity (FC) quantifies the temporal coherence of blood-oxygen-level-dependent (BOLD) signals across brain regions. Recently, the information-theoretic 'complexome' framework has linked FC to coinciding 'complexity drops': transient moments in which regional BOLD signals simultaneously become regular. [...]

The genetic architecture of sporadic Early-Onset Alzheimer Disease (sEOAD, onset ≤65 years) remains largely unknown. To assess the de novo mutation (DNM) hypothesis, we performed a nationwide recruitment of 37 novel sEOAD patients-unaffected parents trios. [...]