Journal Article

Spatial biology has emerged as a pivotal area in many life science fields, with mass spectrometry imaging (MSI) becoming a cornerstone for molecular imaging. Among recent advancements to increase sensitivity, MALDI-2 technology has significantly expanded the molecular space accessible to MSI, increasing the ion yields of neutral metabolites, such as sterols. [...]

Immune checkpoint inhibitors (ICI) and chimeric antigen receptor T‑cell (CAR-T) therapies have fundamentally transformed oncology. With their increasing use, immune-related adverse events (irAEs) have gained attention, including those affecting the nervous system.To describe the clinical and imaging characteristics of neurological immune-related adverse events (NirAEs) under ICI and CAR‑T therapy, as well as their differential diagnostic and therapeutic implications.Review of current literature on the incidence, clinical spectrum, and imaging features of NirAEs.NirAEs occur in approximately 1-6% of patients treated with ICIs. [...]

Glioblastoma (GBM) is a devastating brain tumor with limited treatment success, partly because in vitro models poorly mimic in vivo complexity. This study introduces a high-throughput 3D culture platform utilizing modular starPEG–glycosaminoglycan (GAG) hydrogels that enable independent control of extracellular matrix (ECM) cues: stiffness, cytokine affinity, matrix metalloproteinase-responsive remodeling, and cell adhesiveness via integrin-binding RGD peptides. [...]

There is a wide treatment heterogeneity for asphyxiated newborn infants between hospitals in Germany. This study aimed to identify the leading entry criteria initiating therapeutic hypothermia (TH) using data from the German Hypothermia Registry.We retrospectively analyzed 262 asphyxiated newborn infants treated with TH across 74 neonatal units in Germany. [...]

Motor performance (MP) is essential for maintaining functional independence, particularly in later life. However, the relationship between MP and sleep quality, depressive symptoms, and their underlying brain substrates remains obscure. [...]

The brain's perineuronal extracellular matrix (ECM) is a crucial factor in maintaining the stability of mature brain circuitry. However, how activity-induced synaptic plasticity is achieved in the adult brain with a dense ECM is unclear. [...]

The cortical asymmetry index evaluates the cortical thickness asymmetry between hemispheres. We investigated cortical asymmetry index in asymptomatic and symptomatic mutation carriers of autosomal dominant Alzheimer's disease to explore the brain asymmetry within the Alzheimer's disease continuum. [...]

Background: Conventional blood sampling for the testing of Alzheimer's disease (AD) biomarkers depends on stringent, time-sensitive, and temperature-dependent protocols for processing, shipping, and storage. Dry plasma spots (DPS) present a simpler, more scalable alternative for the collection, storage, and transport of blood samples and may offer an alternative sampling when access to blood volume is limited. [...]

Noninvasive measurement of the human brain's angioarchitecture is essential for understanding functional neuroimaging signals, diagnosing cerebrovascular diseases, and tracking neurodegeneration. Ultrahigh-field MRI now enables mesoscopic (<0.5 millimeters) imaging, revealing vascular details previously inaccessible in vivo. [...]

Socio-cognitive assessment in neurocognitive disorders (NCDs) is rare in clinical practice and no consensus exists as to a uniform operationalization of socio-cognitive measures for NCDs in memory clinics. The SIGNATURE initiative aims to optimize the use of socio-cognitive measures in memory clinics, defining expert recommendations. [...]