Journal Article

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2024-06-12
15:33
[DZNE-2024-00758] Journal Article (Review Article)
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Future avenues in Drosophila mushroom body research.
Learning & memory 31(5), a053863 () [10.1101/lm.053863.123]
How does the brain translate sensory information into complex behaviors? With relatively small neuronal numbers, readable behavioral outputs, and an unparalleled genetic toolkit, the Drosophila mushroom body (MB) offers an excellent model to address this question in the context of associative learning and memory. Recent technological breakthroughs, such as the freshly completed full-brain connectome, multiomics approaches, CRISPR-mediated gene editing, and machine learning techniques, led to major advancements in our understanding of the MB circuit at the molecular, structural, physiological, and functional levels. [...]
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2024-06-11
13:15
[DZNE-2024-00754] Journal Article
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Prediction of depressive symptoms at high age (80+) by psychological, biological and functional factors.
Late-life depression (LLD) is highly prevalent, especially in people aged 80 years and older. We aimed to investigate predictors and their influence on depressive symptoms in LLD.We analysed data from the NRW80+ study, a population-based cross-sectional study of individuals aged 80 years and older. [...]
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2024-06-11
13:12
[DZNE-2024-00753] Journal Article (Review Article)
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Efficacy, acceptability and side-effects of oral versus long-acting- injectables antipsychotics: Systematic review and network meta-analysis.
Long-acting injectable antipsychotics (LAIs) are primarily used for relapse prevention, but in some settings and situations, they may also be useful for acute treatment of schizophrenia. We conducted a systematic review and frequentist network meta-analysis of randomized-controlled trials (RCTs), focusing on adult patients in the acute phase of schizophrenia. [...]
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2024-06-11
13:09
[DZNE-2024-00752] Journal Article
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Preoperative Delirium Risk Screening in Patients Undergoing a Cardiac Surgery: Results from the Prospective Observational FINDERI Study.
Postoperative delirium (POD) is a common complication of cardiac surgery that is associated with higher morbidity, longer hospital stay, cognitive decline, and mortality. Preoperative assessments may help to identify patients´ POD risk. [...]
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2024-06-10
12:38
DBCoverage [DZNE-2024-00751] Journal Article
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Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis
Objective: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor regulating xenobiotic responses as well as physiological metabolism. Dietary AhR ligands activate the AhR signaling axis, whereas AhR activation is negatively regulated by the AhR repressor (AhRR). [...]
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2024-06-10
09:41
DBCoverage [DZNE-2024-00750] Journal Article
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Smartwatch-Based Interventions for People With Dementia: User-Centered Design Approach.
JMIR aging 7, e50107 () [10.2196/50107]
Assistive technologies can help people living with dementia maintain their everyday activities. Nevertheless, there is a gap between the potential and use of these materials. [...]
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2024-06-10
09:39
DBCoverage [DZNE-2024-00749] Journal Article
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Colonoscopy and Subsequent Risk of Parkinson's Disease.
Parkinson's disease (PD) is caused by the misfolding and aggregation of α-synuclein in neurons into toxic oligomers and fibrils that have prion-like properties allowing them to infect healthy neurons and to be transmitted to animal models of PD by injection or oral exposure. Given α-synuclein fibrils' potential transmission on the gut-brain axis, α-synuclein may be transmitted through colonoscopy procedures.This study examines a possible association between colonoscopy and PD.Longitudinal health insurance data of 250,000 individuals aged 50+ from 2004-2019 was analyzed. [...]
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2024-06-10
09:37
DBCoverage [DZNE-2024-00748] Journal Article
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Association of Misfolded α-Synuclein Derived from Neuronal Exosomes in Blood with Parkinson's Disease Diagnosis and Duration.
Misfolded α-synuclein can be detected in blood samples of Parkinson's disease (PD) patients by a seed amplification assay (SAA), but the association with disease duration is not clear, yet.In the present study we aimed to elucidate whether seeding activity of misfolded α-synuclein derived from neuronal exosomes in blood is associated with PD diagnosis and disease duration.Cross-sectional samples of PD patients were analyzed and compared to samples of age- and gender-matched healthy controls using a blood-based SAA. Presence of α-synuclein seeding activity and differences in seeding parameters, including fluorescence response (in arbitrary units) at the end of the amplification assay (F60) were analyzed. [...]
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2024-06-10
09:35
DBCoverage [DZNE-2024-00747] Journal Article
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Automated Capillary Electrophoresis Immunoblot for the Detection of Alpha-Synuclein in Mouse Tissue.
Alpha-synuclein (aSyn) is a key player in neurodegenerative diseases such as Parkinson's disease (PD), dementia with Lewy bodies, or multiple system atrophy. aSyn is expressed throughout the brain, and can also be detected in various peripheral tissues. [...]
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2024-06-10
09:33
[DZNE-2024-00746] Journal Article
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Management of seizures in patients with primary mitochondrial diseases: consensus statement from the InterERNs Mitochondrial Working Group.
Primary mitochondrial diseases (PMDs) are common inborn errors of energy metabolism, with an estimated prevalence of one in 4300. These disorders typically affect tissues with high energy requirements, including heart, muscle and brain. [...]
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