Journal Article

Calcium Homeostasis Modulator Protein 6 or CALHM6 is a tetraspanin-like membrane glycoprotein from the family with sequence similarity 26, member F (FAM26F) that majorly contributes to regulating gene expression and various cellular processes. Substantial evidence supports CALHM6 to be a calcium modulator with a potential immune-modulatory role in various infections and cancer, however, the associated signaling cascades and related functional details are largely unknown and have yet to be investigated for its exploitation as a therapeutic candidate.The current study exploited mass spectrometry-based proteome analysis to analyze differentially expressed proteins in in-vitro knockdown (via a siRNA-based approach ) as well as overexpression (plasmid-mediated) models of CALHM6. [...]

This study aimed to investigate the longitudinal change of verbal fluency after COVID-19 and potential influencing factors in a community-based sample. Within the COVIMMUNE-Clin study at the University of Bonn Medical Center, participants with a mild course of COVID-19 (n = 52), a severe course (n = 52), and healthy controls (n = 55) were compared. [...]

Emotion recognition is an essential component of socio-emotional functioning, yet its alteration in mild cognitive impairment (MCI) remains insufficiently understood, particularly in relation to neural mechanisms. This study examined behavioral and neural responses to facial emotions in 60 adults (30 MCI, 30 healthy controls (HC)) using a validated fMRI emotion-recognition paradigm with anger, fear, sadness, happiness, and neutral expressions. [...]

Translocator protein (TSPO)-PET imaging facilitates monitoring of glioblastoma in preclinical models and patients. However, specificity of TSPO-PET signals remains to be investigated. [...]

Early progression after PRRT occurs in a subset of patients with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Associations between body composition and early PET-based progression after PRRT were assessed.In this retrospective analysis, 321 patients undergoing PRRT were screened. [...]

Parkinson's disease (PD) is a complex heterogeneous neurodegenerative syndrome that is clinically defined. However, how it begins at the molecular and systems level remains unresolved. [...]

Renal toxicity after peptide receptor radionuclide therapy (PRRT) is commonly assessed using Common Terminology Criteria for Adverse Events (CTCAE), whereas nephrological classification relies on Kidney Disease: Improving Global Outcomes (KDIGO)-based renal function categories. We compared CTCAE- and KDIGO-derived eGFRcr-based definitions of renal function deterioration after PRRT and evaluated their predictive value for subsequent long-term renal outcome.149 gastroenteropancreatic neuroendocrine tumor patients scheduled for PRRT with renal follow-up for at least 12 months after treatment were included. [...]

Endovascular thrombectomy (EVT) is established for large infarcts, but remains cautiously applied in extensive infarcts with an Alberta Stroke Program Early CT Score (ASPECTS) of 0-2. Real-life outcome data remain limited.Retrospective analysis of the German Stroke Registry-Endovascular Treatment comparing extensive (ASPECTS 0-2) and large infarcts (ASPECTS 3-5) in patients with anterior-circulation occlusion and EVT. [...]

Neuroinfectious diseases (NDs) are potentially treatable conditions associated with substantial morbidity, but their clinical course remains difficult to predict. While specific MRI patterns are characteristic of distinct aetiologies, their prognostic value remains poorly investigated. [...]

Real-time quaking-induced conversion (RT-QuIC) of recombinant prion protein is a biomarker for Creutzfeldt-Jakob disease (CJD). RT-QuIC assesses a sample's seeding activity across multiple wells. [...]