Journal Article

DZNE-2025-01322

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Associations of lifestyle factors with amyloid pathology in persons without dementia.

Oomens, J. E. ; Vos, S. J. ; Maserejian, N. N. ; Boada, M. ; Didic, M. ; Engelborghs, S. ; Fladby, T. ; van der Flier, W. M. ; Frisoni, G. B. ; Fröhlich, L. ; Gill, K. D. ; Grimmer, T. ; Hort, J. ; Itoh, Y. ; Iwatsubo, T. ; Klimkowicz-Mrowiec, A. ; Landau, S. M. ; Lee, D. Y. ; Lleó, A. ; Martinez-Lage, P. ; de Mendonça, A. ; Meyer, P. T. ; Parchi, P. ; Pardini, M. ; Parnetti, L. ; Popp, J. ; Rami, L. ; Reiman, E. M. ; Rinne, J. O. ; Rodrigue, K. M. ; Sánchez-Juan, P. ; Santana, I. ; Scarmeas, N. ; Scheltens, P. ; Skoog, I. ; Sperling, R. A. ; Stern, Y. ; Villeneuve, S. ; Waldemar, G. ; Wiltfang, J.Extern* ; Zetterberg, H. ; Alcolea, D. ; Allegri, R. F. ; Altomare, D. ; Bateman, R. J. ; Baiardi, S. ; Baldeiras, I. ; Blennow, K. ; Braber, A. d. ; van Buchem, M. A. ; Byun, M. S. ; Cerman, J. ; Chen, K. ; Chipi, E. ; Day, G. S. ; Drzezga, A.Extern* ; Ekblad, L. L. ; Förster, S. ; Fortea, J. ; Freund-Levi, Y. ; Frings, L. ; Guedj, E. ; Habeck, C. G. ; Handels, R. ; Hausner, L. ; Hellwig, S. ; Jiménez-Bonilla, J. F. ; Juaristi, A. I. ; Kandimalla, R. ; Kern, S. ; Bordewick Kirsebom, B. S. ; Kornhuber, J. ; Legdeur, N. ; Levin, J.DZNE* ; Maier, W. ; Marquié, M. ; Minatani, S. ; Morbelli, S. D. ; Mroczko, B. ; Ntanasi, E. ; de Oliveira, C. R. ; Orellana, A. ; Peters, O.Extern* ; Prabhakar, S. ; Ramakers, I. H. ; Rodríguez-Rodriguez, E. ; Ruiz, A. ; Rüther, E. ; Sakhardande, J. ; Selnes, P. ; Silva, D. ; Soininen, H. ; Spiru, L. ; Takeda, A. ; Teunissen, C. E. ; Tijms, B. M. ; Vermunt, L. ; Wallin, Å. K. ; Wiels, W. ; Yannakoulia, M. ; Yi, D. ; Zettergren, A. ; Initiative, A. D. N. (Collaboration Author) ; group, A. S. (Collaboration Author) ; Network, D. I. A. (Collaboration Author) ; Dementia, E. P. o. A. (Collaboration Author) ; Japan Alzheimer's Disease Neuroimaging Initiative , K. B. A. S. (J-ADNI) ; Disease, P. o. A. (Collaboration Author) ; Disease, P. E. o. E. o. N. T. f. A. (Collaboration Author) ; Ossenkoppele, R. ; Verhey, F. R. ; Visser, P. J. ; Jansen, W. J. ; Early Diagnosis (Collaboration author)

2025
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.1177/13872877251379083

Abstract: BackgroundThe association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood.ObjectiveThe aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology.MethodsFor this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology.ResultsWe included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE ε4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE ε4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66-0.89, p < 0.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR = 0.85, 95%CI 0.73-0.99, p = 0.029; OR = 0.62, 95%CI 0.45-0.86, p = 0.004).ConclusionsIn NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.

Keyword(s): Humans (MeSH) ; Female (MeSH) ; Male (MeSH) ; Aged (MeSH) ; Life Style (MeSH) ; Cross-Sectional Studies (MeSH) ; Cognitive Dysfunction: pathology (MeSH) ; Cognitive Dysfunction: psychology (MeSH) ; Cognitive Dysfunction: metabolism (MeSH) ; Cognitive Dysfunction: genetics (MeSH) ; Aged, 80 and over (MeSH) ; Alcohol Drinking (MeSH) ; Smoking (MeSH) ; Middle Aged (MeSH) ; Amyloid: metabolism (MeSH) ; Apolipoprotein E4: genetics (MeSH) ; Dementia (MeSH) ; Alzheimer's disease ; amyloid ; amyloid biomarker study ; cerebrospinal fluid ; lifestyle ; positron emission tomography ; Amyloid ; Apolipoprotein E4

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Contributing Institute(s):

1. Clinical Research (Munich) (Clinical Research (Munich))
2. Clinical Neurodegeneration (AG Levin)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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