Publications Database

Remote self-assessment of the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) using digital data capture was investigated for its feasibility as an add-on to ALSFRS-R assessments during multidisciplinary clinic visits. From August 2017 to December 2021, at 12 ALS centers in Germany, an observational study on remote assessment of the ALSFRS-R was performed. [...]

Data relative to 'Somatostatin interneurons activated by 5-HT 2A receptor suppress slow oscillations in medial entorhinal cortex'

Falls in older adults with mild cognitive impairment (MCI) are a major health issue. For healthy individuals, higher variability in minimum toe clearance (MTC) during gait is associated with the risk of tripping-related falls and dance intervention reduces MTC variability. [...]

Research in the field of prion diseases has not only shed light on the mechanisms underlying transmissible spongiform encephalopathies (TSEs) but has also influenced the broader understanding of protein misfolding disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and other tauopathies and synucleinopathies. Although prion diseases are rare and invariably fatal, they have provided an invaluable conceptual framework for the study of age-associated neurodegenerative disorders. [...]

The present invention relates to compounds that show a positive result in a phosphatase activation assay with protein phosphatase 5 according to the invention, to compounds that bind in an in vitro binding assay to a certain region of the amino acid sequence of protein phosphatase 5, as well as to compounds that show a positive result in a phosphatase activation assay with protein phosphatase 5 according to the invention and bind in an in vitro binding assay to a certain region of the amino acid sequence of protein phosphatase 5. The present invention also relates to pharmaceutical compositions comprising one or more of such compounds, to methods of using such a compound, and to methods of screening for compounds that activate protein phosphatase 5..

Photobiomodulation, a therapeutic method promoting wound healing, reduction in inflammation, pain and apoptosis, was widely tested in neurological/psychiatric disorders. In Parkinson's disease positive results have been obtained recently by transcranial or deep-fiber-optic-based near-infrared (NIR) light application. [...]

Object-location memory (OLM) is essential for remembering the locations of objects within an environment and is often impaired in aging and neurodegenerative diseases. Transcranial direct current stimulation (tDCS) has shown promise for improving OLM, although study outcomes have varied considerably. [...]

Mutations or deletions in the SHANK3 gene have been identified in up to 1% of autism spectrum disorder cases and are considered the primary cause of neuropsychiatric symptoms in Phelan McDermid syndrome (PMS). While synaptic dysfunctions have been extensively documented in the absence of Shank3, other mechanisms through which Shank3 may regulate neuronal functions remain unclear. [...]

Depression is characterized by heterogeneous symptom patterns. We investigated different facets of depressive symptoms and their role in predicting the longitudinal outcome of psychotherapy in late-life depression (LLD).This is a secondary analysis of a multicenter, randomized clinical trial in 229 LLD patients. [...]

Beyond the vast array of functional roles attributed to serotonin (5-HT) in the brain, changes in 5-HT levels have been shown to accompany changes in behavioral states, including WAKE, NREM, and REM sleep. Whether 5-HT dynamics at shorter time scales can be seen to delineate substates within these larger brain states remains an open question. [...]