Publications Database

QCima Studio is a standalone software application for quality control of MACSima spatial proteomics datasets. It provides convenient access to review individual antibody signals alongside their corresponding background and autofluorescence reference images.Users can adjust visualization settings, classify signals as accepted or discarded, and automatically organize imaging data by scene (Rack–Well–ROI), antibody, and autofluorescence reference.The software is designed for fast, script-free QC workflows and supports session saving, analysis resumption, structured metadata review, and seamless transfer of QC decisions back to MACS iQ View..

Model weights for YADO (You Accurately Denoise real Observations) Denoiser and Renoiser as introduced in the paper "Rethinking Real-World MRI Denoising: Learning from Physical Noise" accepted to ECCV 2026. See also the Project Page.The code and docs are at: github.com/Deep-MI/YADO, and the weights are mostly also compatible with YODA. [...]

Data and code for the publication "A novel analysis method for condensate wetting identifies charge-dependent Tau-membrane interactions", located at [DOI will be updated when available]..

Overlooked opportunities can help turn academic research into socioeconomic impact across Europe..

The cGAS–STING pathway is a central mediator of antiviral immunity, yet its constitutive activation causes severe systemic autoinflammatory disease and neurodegeneration. Intermittent fasting (IF) has been proposed as a non-pharmacological strategy to attenuate inflammation and neurodegeneration. [...]

Animals rely on neural representations of sensory stimuli to rapidly recognize familiar environments and precisely identify salient cues. In the Drosophila mushroom body, odors are represented by the activity of Kenyon cells (KCs), whose random wiring with olfactory projection neurons (PNs) is generally thought to promote odor discrimination. [...]

Epilepsy is a relevant comorbidity of dementia due to Alzheimer's Disease (AD) and probably directly related to its pathology. We aimed to generate hypotheses how interictal epileptiform discharges (IEDs) may be associated with pathological levels of AD markers from cerebrospinal fluid (CSF).To perform bivariate analyses between IEDs or EEG background slowing to CSF AD markers including amyloid-β42 to amyloid-β40 ratio (Aβ ratio), total tau and phospho-tau.In this retrospective cross-sectional study, we identified 26 clinical AD patients who presented with at least one of three pathological neurodegeneration markers in the CSF (Aβ ratio ≤0.5, total tau ≥370 pg/ml, phospho-tau ≥66 pg/ml) and received at least one routine EEG.IEDs and EEG background slowing were present in 5/26 and 14/26 patients, respectively. [...]

Superoxide dismutase 1 (SOD1), originally regarded as an antioxidant enzyme, is now recognized as a multifunctional protein whose conformational instability and aggregation contribute to neurodegeneration. The emerging evidence suggests that SOD1 pathology extends beyond amyotrophic lateral sclerosis, supporting a role in multiple neurodegenerative diseases. [...]

Amyloid positron emission tomography (PET) is increasingly used in research and clinical settings to determine the etiology of cognitive decline and eligibility for amyloid-targeting therapies. To assist with amyloid PET evaluation and to guide clinical decision-making, images can be quantified in a standardized unit called Centiloid, the interpretation of which can vary according to the method and threshold used.To collect Centiloid values from available studies and determine robust positivity cutoffs using data-driven methods and correspondence with visual reads.PubMed search (October 2024) identified studies with Centiloid values. [...]