Publications Database

Resistance to age-related pathological changes (brain maintenance), including Alzheimer’s disease, cerebrovascular disease, and neurodegeneration may promote cognitive resilience in aging. However, how lifestyle and health profiles relate to successful cognitive and brain aging remains poorly understood. [...]

Proton channels are transmembrane proteins that enable selective proton (H+) transport. The voltage-gated proton channel Hv1 or HVCN1 is the only one found in mammalian cells, primarily in immune cells, where it facilitates rapid proton extrusion in response to membrane depolarization, mediating outward proton currents. [...]

HintergrundModelle, die Menschen mit Demenz und Angehörige sowie Expert:innen aus verschiedenen Versorgungssettings in Forschung aktiv einbeziehen, sind bisher im deutschsprachigen Kontext nicht implementiert. Diese sind notwendig, um auch die Perspektive der „Mitforschenden“ aktiv einzubinden und Themen aufzugreifen, die sich am Alltag von Menschen mit Demenz und ihren Angehörigen und in der Versorgungspraxis Tätigen orientieren.Ziel der ArbeitDas Ziel ist die Entwicklung eines vorläufigen Frameworks für gemeinsames Forschen.Material und MethodenDas Vorgehen beinhaltet einen partizipativen Ansatz mit Stakeholdern verschiedener Personengruppen. [...]

AimStudies on the social environment of people with dementia are largely limited to the closest informal contacts of people with dementia. The aim of this study was to gain a deeper understanding of the roles of both informal and formal contacts.Subject and methodsParticipants (n = 405) who replied to items concerning the social networks of people with dementia in the Social Resources in the Living Environment of People with Dementia (SoRe-Dem) Study were included. [...]

Data on chronic autoimmune neuropathies (CAN) requiring intensive care unit (ICU) treatment are limited. This study investigated clinical and neuropathological features, immunotherapies, and outcomes of ICU-treated CAN patients.Retrospectively, we analyzed patients with CAN admitted to the ICU between 2007 and 2024. [...]

The treatment of carotid artery stenosis (CAS) for stroke prevention is a matter of debate due to conflicting data, missing recent data, and advances in medical treatment options but also in interventional techniques and surgery. Therefore, the establishment of an easily available marker for brain damage might be a key tool in this patient group to guide treatment.A retrospective cross-sectional study was conducted leveraging a vascular surgery biobank of 95 patients aged 60 to 80 years. [...]

Digital speech-based assessments provide scalable tools for detecting subtle cognitive decline. Here, we investigated whether digitally derived speech-based composite score of cognition and individual speech features were associated with alterations in functional connectivity (FC) within task-related brain networks in the Alzheimer's disease spectrum, which are known to reflect cognitive performance and disease-related changes.Data were analyzed from 129 participants of the German PROSPECT-AD study, ranging from cognitively healthy individuals to those with mild cognitive impairment. [...]

Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer's disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse. [...]

Recent evidence suggests glial dysfunction, particularly involving oligodendrocytes and myelin, as an important part of the primary disease mechanism of sporadic Creutzfeldt–Jakob disease. To the best of our knowledge, cerebrospinal fluid (CSF) biomarkers reflecting oligodendrocyte or myelin damage have not yet been systematically investigated in this context. [...]

Weight loss and hypermetabolism are early and prognostically significant features of amyotrophic lateral sclerosis (ALS) and are associated with hypothalamic atrophy and degeneration of melanin-concentrating hormone (MCH) neurons that regulate energy balance. To investigate whether MCH vulnerability arises from upstream network dysfunction, we performed whole-brain retrograde rabies tracing in SOD1G93A mice. [...]