Publications Database

Neural circuits undergo experience-dependent plasticity to form long-lasting memories, but how inhibitory interneurons contribute to this process remains poorly understood. Using miniature microscope calcium imaging, we monitored the activity of large amygdala interneuron populations in freely moving mice during fear learning and extinction. [...]

Recently, ultra-high-field MRI (UHF-MRI) has become more available and one of the best tools to study the brain for neuroscientists. One common step in quantitative neuroimaging is to segment the brain into several regions, which has been done using software packages such as FreeSurfer, FastSurferVINN, or SynthSeg. [...]

The German Dementia Registry (DEMREG) is a large-scale national prospective biomarker-based study for cognitive impairment and dementia, providing an integrated clinical research platform for research studies.The DEMREG study longitudinally collects demographic, clinical, genetic, biological, and imaging data, along with risk factors and treatment information from real-world settings. Comprehensive clinical assessments are conducted yearly. [...]

Childhood maltreatment is associated with an unhealthier lifestyle in adulthood and an increased risk of mental and somatic health problems, although the underlying pathways remain unclear. This study examined whether smoking and overweight mediate the association between childhood abuse/neglect and frequent adult diseases, including cancer, myocardial infarction, stroke, type 2 diabetes, chronic obstructive pulmonary disease, depression, and anxiety.Childhood maltreatment was assessed in 152,887 German National Cohort (NAKO) participants using the Childhood Trauma Screener. [...]

The use of large language models (LLMs) in clinical diagnostics and intervention planning is expanding, yet their utility for personalized recommendations for longevity interventions remains opaque. We extended the BioChatter framework to benchmark LLMs' ability to generate personalized longevity intervention recommendations based on biomarker profiles while adhering to key medical validation requirements. [...]

Extended nursing roles in dementia can improve treatment, care, and patient and caregiver outcomes. We tested the efficacy and cost-effectiveness in people living with dementia (PlwD) and caregivers.We analyzed data from 417 PlwD within the multicenter, cluster-randomized InDePendent trial six months after baseline. [...]

Lafora disease (LD) is a severe, ultra-rare childhood-onset progressive myoclonus epilepsy caused by biallelic pathogenic variants in either EPM2A or NHLRC1 and currently without cure. Body fluid-derived biomarkers have remained largely unexplored in LD. [...]

Antinuclear antibodies (ANAs) are central biomarkers in rheumatological conditions and can drive disease pathology. Much less is known about the role of ANAs in neurological symptoms, although a number of experimental studies have demonstrated direct effects on neuronal function, for example in neuropsychiatric lupus erythematosus. [...]

Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) are neurodegenerative disorders diagnosed by clinical criteria with limited diagnostic specificity in early stages. Diagnostic biomarkers facilitating early and precise diagnosis are needed. [...]