Publications Database

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2025-03-24
13:10
[DZNE-2025-00460] Journal Article/Contribution to a conference proceedings/Contribution to a book
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Preface
Shape in Medical Imaging / Reuter, Martin (Editor) [0000-0002-2665-9693] ; Cham : Springer International Publishing, 2018, ; ISSN: 0302-9743=1611-3349 ; ISBN: 978-3-030-04746-7=978-3-030-04747-4 ; doi:10.1007/978-3-030-04747-4
International Workshop on Shape in Medical Imaging, ShapeMI, GranadaGranada, Spain, 20 Sep 20182018-09-20
Lecture notes in computer science LNCS 11167, () [10.1007/978-3-030-04747-4]
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2025-03-24
13:04
[DZNE-2025-00459] Journal Article/Contribution to a conference proceedings/Contribution to a book
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DLMIA 2018 Preface
Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support / Stoyanov, Danail (Editor) ; Cham : Springer International Publishing, 2018, ; ISSN: 0302-9743=1611-3349 ; ISBN: 978-3-030-00888-8=978-3-030-00889-5 ; doi:10.1007/978-3-030-00889-5
4th International Workshopon Deep Learning in Medical Image Analysis, DLMIA, GranadaGranada, Spain, 20 Sep 20182018-09-20
Lecture notes in computer science 11045 LNCS, VII ()
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2025-03-19
09:52
OpenAccess [DZNE-2025-00437] Journal Article
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Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function.
Alzheimer's disease (AD) is the leading cause of dementia, characterized by the accumulation of amyloid-beta (Aβ) and neurofibrillary tangles. Recent studies emphasize the role of vascular factors, including the glymphatic system, in AD pathogenesis, particularly in Aβ clearance. [...]

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2025-03-19
09:31
OpenAccess [DZNE-2025-00436] Journal Article
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Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's disease.
Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson's disease but also one of the most common co-pathologies in Alzheimer's disease (AD). Preclinical studies suggest that αSyn can exacerbate tau aggregation, implying that αSyn co-pathology may specifically contribute to the Aβ-induced aggregation of tau that drives neurodegeneration and cognitive decline in AD. [...]
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2025-03-19
09:29
OpenAccess [DZNE-2025-00435] Journal Article
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Social differences in cause-specific infant mortality at the dawn of the demographic transition: New insights from German church records.
Little is known about social gradients in cause-specific infant mortality in the nineteenth century. To our knowledge, this is the first paper to explore this connection for the time prior to the epidemiologic and demographic transitions. [...]

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2025-03-19
09:26
OpenAccess [DZNE-2025-00434] Journal Article
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Myelin water fraction mapping with joint inversion of gradient-echo and spin-echo data.
Accurate estimation of brain myelin-water content from multi-echo data is challenging due to the inherent ill-posedness of the inversion problem. In this study, we propose a novel method for myelin-water imaging that jointly utilizes gradient-echo and spin-echo imaging data to enhance the accuracy of myelin-water estimation.Multi-echo gradient-echo and spin-echo data were simulated and acquired in vivo. [...]

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2025-03-18
14:23
[DZNE-2025-00433] Journal Article (Erratum/Correction)

Correction for Bahari-Javan et al., HDAC1 links early life stress to schizophrenia-like phenotypes
NEUROSCIENCE Correction for “HDAC1 links early life stress to schizophrenia-like phenotypes,” by Sanaz Bahari-Javan, Hristo Varbanov, Rashi Halder, Eva Benito, Lalit Kaurani, Susanne Burkhardt, Heike Anderson-Schmidt, Ion Anghelescu, Monika Budde, Roman M. Stilling, Joan Costa, Juan Medina, Detlef E. [...]
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2025-03-17
15:13
OpenAccess [DZNE-2025-00432] Journal Article
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Generation of ten human induced pluripotent stem cell lines (hiPSCs) from patients with and without Chemotherapy-Induced Peripheral Neuropathy (CIPN) and Post Chemotherapy Cognitive Impairment (PCCI).
Chemotherapy-induced peripheral neuropathy (CIPN) and post-chemotherapy cognitive impairment (PCCI) represent major side effects of chemotherapy. Using Sendai virus vectors, ten hiPSC lines from patients who had undergone chemotherapy and did or did not develop CIPN and PCCI were generated. [...]

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2025-03-17
15:09
OpenAccess [DZNE-2025-00431] Journal Article
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Cytokine atlas of the population-based cohort SHIP-TREND-0 - Associations with age, sex, and BMI.
Cytokine 189, 156896 () [10.1016/j.cyto.2025.156896]
The characterization of physiological immune signatures in a population-based cohort is a prerequisite for identifying pathological immune signatures associated with inflammatory or autoimmune diseases.Here, 47 plasma cytokines, chemokines, and growth factors were quantified with a bead-based multiplex-assay (Merck HCYTA-60 K) using a FLEXMAP 3D™ instrument in 1175 individuals of the Study of Health in Pomerania (SHIP; TREND cohort, 532 men and 643 women, age: 20 to 81, BMI: 17.7 to 53.6). Associations of cytokine concentrations with age, sex, BMI, season, and blood cell parameters (BCP) were examined by multivariate regression models.The physiological cytokine concentrations differed strongly between analytes, with median concentrations ranging from 0.6 to 7820 pg/mL. [...]

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2025-03-14
14:04
DBCoverage [DZNE-2025-00430] Journal Article
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The late-onset Alzheimer’s disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis
Life science alliance 8(5), e202403080 () [10.26508/lsa.202403080]
The cell surface receptor TREM2 is a key genetic risk factor and drug target in Alzheimer’s disease (AD). In the brain, TREM2 is expressed in microglia, where it undergoes proteolytic cleavage, linked to AD risk, but the responsible protease in microglia is still unknown. [...]
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