Publications Database

Open data repository, Knab et al., Prediction of stroke outcome in mice based on non-invasive MRI and behavioral testing Open data repository Knab et al. Prediction of stroke outcome in mice based on non-invasvive MRI and behavioral testing Content: README.txt This information dat Contains MRI data in NIFTI format and secondary data from atlas registration [...]

Open data repository, Knab et al., Prediction of stroke outcome in mice based on non-invasive MRI and behavioral testing Latest version: repository_v2.0.zip, please ignore repository.zip Open data repository Knab et al. Prediction of stroke outcome in mice based on non-invasvive MRI and behavioral testing Content: README.txt This information dat Contains MRI data in NIFTI format and secondary data from atlas registration [...]

Open data repository, Knab et al., Prediction of stroke outcome in mice based on non-invasive MRI and behavioral testing Latest version of files: repository_v2.0.zip and Behavior Data.xlsx, please ignore repository.zip Open data repository Knab et al. Prediction of stroke outcome in mice based on non-invasvive MRI and behavioral testing Content: README.txt This information dat Contains MRI data in NIFTI format and secondary data from atlas registration [...]

Gender differences in progressive supranuclear palsy (PSP) may become relevant for clinical trials, treatment decisions and patient counseling. To study gender associated differences we conducted a retrospective data analysis of 191 male and 157 female PSP patients from a large multicenter observational cohort in Germany. [...]

While significant progress has been made in treating Parkinson's disease (PD) symptoms, disease-modifying therapies (DMTs) have consistently failed. To address the underlying molecular mechanisms of PD, two biology-based criteria have been proposed: the 'Synucleinopathy-Neurodegeneration-Genetics' (SynNeurGe) and 'neuronal α-synuclein disease' (NSD) frameworks. [...]

Advancements over the past decade in understanding vesicular monoamine transporter 2 (VMAT2) inhibitors highlight their key role in the treatment of movement and neuropsychiatric disorders. VMAT2 is crucial for packaging neurotransmitters such as serotonin, dopamine, and norepinephrine into synaptic vesicles, facilitating their release and reuptake in synaptic transmission. [...]

Alzheimer's disease (AD) often begins with non-cognitive symptoms such as olfactory deficits, which can predict later cognitive decline, though the mechanisms remain unclear. Pathologically, the brainstem locus coeruleus (LC), the main source of the neurotransmitter noradrenalin (NA) modulating olfactory information processing is affected early. [...]

The P4D (Personalized, Predictive, Precise & Preventive Medicine for Major Depression) dashboard (https://p4dashboard.vercel.app) is a web-based platform for monitoring and generating data-driven insights within a multi-site clinical depression study. Part of the broader P4D initiative, which aims to advance personalized medicine for depression through deep phenotyping, genotyping, and machine learning, the dashboard addresses the challenge of integrating heterogeneous data sources. [...]

Background:Cerebral small vessel disease (CSVD) is a common neurological condition that contributes to strokes, dementia, disability, and mortality worldwide. We conducted a systematic review and meta-analysis to investigate the use of neuroimaging CSVD markers in machine learning (ML) based diagnosis and prognosis of cognitive impairment and dementia, and identify both methodological changes over time and barriers to clinical translation.Methods:Following the PRISMA guidelines, we systematically searched for original studies that used both neuroimaging CSVD markers and ML methods for diagnosing and prognosing neurodegenerative diseases (preregistration in PROSPERO: CRD42022366767). [...]

Long-read RNA sequencing has transformed transcriptome analysis by enabling comprehensive mapping of full-length transcripts, providing an unprecedented resolution of transcript diversity, alternative splicing and transcript-specific regulation. In this study, we employed nanopore long-read RNA sequencing to profile the transcriptomes of three cell types commonly used to model brain disorders, human fibroblasts, induced pluripotent stem cells and stem cell-derived cortical neurons, identifying extensive transcript diversity with 15 072 transcripts in stem cell-derived cortical neurons, 13 048 in fibroblasts and 12 759 in induced pluripotent stem cells. [...]