AG Spottke
Clinical Research Platform (CRP)
Also known as:AG Spottke; Clinical Research (Bonn); Clinical Research Platform - CRP; Clinical Trial Unit; Klinische Forschung (Bonn); Klinische Forschungsplattform; Klinische Forschungsstation
⇧ BN DZNE ⇧
Recent Publications
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Journal Article
Ufer, F.Extern* ; Rößling, R. (First author)DZNE* ; Spottke, A.DZNE* ; Németh, R. ; Schaprian, T.DZNE* ; Coninck, N. K.DZNE* ; Gamez, A.DZNE* ; Sterl, R.DZNE* ; Naumann, P.DZNE* ; Behr, N. ; Maier, A. ; Meyer, T. ; Weydt, P.DZNE* ; Prüss, H. (Last author)DZNE*
ABCD-Trial: study protocol for a randomized, double-blind, placebo-controlled study in patients with Amyotrophic lateral sclerosis for the evaluation of efficacy and safety of B-Cell Depletion with rituximab (ABCD).
Trials 27(1), 615 (2026) [10.1186/s13063-026-10022-z]2026
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Rizzo, M. ; Teunissen, C. E. ; Zetterberg, H. ; Blennow, K. ; Kollmorgen, G. ; Krüger, R. ; Fernandes, S. B. G. ; Aarsland, D. ; Borejko, O. ; Hu, M. ; Chokoshvili, D. ; Vijverberg, J. E. G. B. ; Lemstra, A. W. ; Tijms, B. M. ; Petzold, G. C.DZNE* ; Brockmann, K.DZNE* ; Gasser, T.DZNE* ; Frisoni, G. B. ; Hort, J. ; Nedelska, Z. ; Hopøy, A.-C. ; Fladby, T. ; Jessen, F.DZNE* ; Düzel, E.DZNE* ; Spottke, A.DZNE* ; Höglinger, G. U.DZNE* ; Mutel, S. ; Chevalier, C. ; Krishnan, R. ; Visser, P. J. ; Vos, S. J. B. ; consortium, E. (Collaboration Author)
Amyloid, p-tau, neurofilament light, and α-synuclein cerebrospinal fluid biomarkers across Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease.
Alzheimer's & dementia / Diagnosis, assessment & disease monitoring 18(4), e70498 (2026) [10.1002/dad2.70498]2026
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Ramedani, M. (First author)DZNE* ; Terli, J. C.DZNE* ; Singh, D.DZNE* ; Peters, O.DZNE* ; Hellmann-Regen, J.DZNE* ; Priller, J.DZNE* ; Spruth, E. J.DZNE* ; Spottke, A.DZNE* ; Boehlen, A.DZNE* ; Weydt, P.DZNE* ; Wüllner, U.DZNE* ; Dinter, E.DZNE* ; Günther, R.DZNE* ; Wiltfang, J.DZNE* ; Schott, B. H.DZNE* ; Düzel, E.DZNE* ; Glanz, W.DZNE* ; Buerger, K.DZNE* ; Janowitz, D.DZNE* ; Levin, J.DZNE* ; Stockbauer, A.DZNE* ; Mladinov, M.DZNE* ; Prudlo, J.DZNE* ; Hermann, A.DZNE* ; Synofzik, M.DZNE* ; Mengel, D.Extern* ; Petzold, G. C.DZNE* ; Schneider, A.DZNE* ; Lüsebrink, F.DZNE* ; Hetzer, S. ; Dechent, P. ; Ewers, M.DZNE* ; Scheffler, K. ; Stöcklein, S.Extern* ; Teipel, S.DZNE* ; Dyrba, M. (Last author)DZNE*
Hybrid multimodal late fusion frameworks for bvFTD classification in imbalanced dementia datasets.
Frontiers in aging neuroscience 18, 1892568 (2026) [10.3389/fnagi.2026.1892568]2026
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Koyak, B. (First author)DZNE* ; Menzel, T. ; Rodemann, M.DZNE* ; Hennes, G.DZNE* ; Spottke, A.DZNE* ; Saxler, E.DZNE* ; Bedarf, J. ; Faber, J.DZNE* ; Sommerauer, M.DZNE* ; Weydt, P.DZNE* ; Reuter, M.DZNE* ; Botsch, M. ; Wuellner, U.DZNE* ; Aziz, N. A. (Last author)DZNE*
Interaction- and asymmetry-aware facial blendshape analysis for objective quantification of Parkinsonian hypomimia.
npj Parkinson's Disease 12(1), 231 (2026) [10.1038/s41531-026-01579-2]2026
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Bai, Y. ; Peters, O.DZNE* ; Freiesleben, S. D.DZNE* ; Fenski, F. ; Priller, J.DZNE* ; Spruth, E. J.DZNE* ; Schneider, A.DZNE* ; Fliessbach, K.DZNE* ; Wiltfang, J.DZNE* ; Bartels, C. ; Rostamzadeh, A. ; Glanz, W.DZNE* ; Teipel, S.DZNE* ; Kilimann, I.DZNE* ; Laske, C.DZNE* ; Spottke, A.DZNE* ; Roy-Kluth, N.DZNE* ; Brosseron, F.DZNE* ; Wagner, M.DZNE* ; Frommann, I.DZNE* ; Lüsebrink, F.DZNE* ; Ramirez, A.DZNE* ; Dechent, P. ; Hetzer, S. ; Scheffler, K. ; Yakupov, R.DZNE* ; Jessen, F.DZNE* ; Düzel, E.DZNE* ; Bainbridge, W. A.
Diagnostic Images for Mild Cognitive Impairment Are Sensitive to Alzheimer's Disease Biomarkers and Reveal Abnormal Scene Processing.
Journal of cognitive neuroscience 38(10), 1884 - 1896 (2026) [10.1162/JOCN.a.2636]2026
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Kasper, E. (First author)DZNE* ; Lehto, A.DZNE* ; Nordmann, N. ; Peters, O.DZNE* ; Hellmann-Regen, J. D. N.DZNE* ; Priller, J.DZNE* ; Spruth, E. J.DZNE* ; Petzold, G. C.DZNE* ; Vogt, I.DZNE* ; Weydt, P.DZNE* ; Bernsen, S.DZNE* ; Dinter, E.DZNE* ; Falkenburger, B.DZNE* ; Günther, R.DZNE* ; Düzel, E.DZNE* ; Glanz, W.DZNE* ; Synofzik, M.DZNE* ; Beichert, L.DZNE* ; Spottke, A.DZNE* ; Wagner, M.DZNE* ; Brosseron, F.DZNE* ; Schmid, M. C.DZNE* ; Schneider, A.DZNE* ; Teipel, S.DZNE* ; Prudlo, J.DZNE* ; Hermann, A. (Last author)DZNE*
Impact of Plasma p-tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS.
Annals of Clinical and Translational Neurology 13(8), 1711 - 1718 (2026) [10.1002/acn3.70423]2026
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Krohn, F.Extern* ; Sarkar, M.Extern* ; Schütze, H.Extern* ; Iliopoulos, P.Extern* ; Penalba-Sánchez, L.DZNE* ; Hämmerer, D.DZNE* ; Yakupov, R.DZNE* ; Lüsebrink-Rindsland, J. F. S.Extern* ; Spottke, A.DZNE* ; Schneider, A.DZNE* ; Roy, N.DZNE* ; Incesoy, E.DZNE* ; Heneka, M.DZNE* ; Kilimann, I.DZNE* ; Kleineidam, L.DZNE* ; Teipel, S. J.DZNE* ; Brosseron, F.DZNE* ; Goerss, D.DZNE* ; Glanz, W.DZNE* ; Schmid, M.Extern* ; Rostamzadeh, A. ; Wagner, M.DZNE* ; Fliessbach, K.DZNE* ; Jessen, F.Extern* ; Düzel, E.DZNE* ; Betts, M. J. (Last author)DZNE*
Substantia Nigra MRI markers are lower in Alzheimer's disease and are linked to general cognitive function
Brain communications 8(4), fcag238 (2026) [10.1093/braincomms/fcag238]2026
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Suksangkharn, Y. (First author)DZNE* ; Schott, B. H.DZNE* ; Zeidman, P. ; Vockert, N.DZNE* ; Lattmann, R.DZNE* ; Schütze, H.DZNE* ; Yakupov, R.DZNE* ; Peters, O.DZNE* ; Hellmann-Regen, J.DZNE* ; Preis, L.Extern* ; Ersözlü, E.DZNE* ; Priller, J.DZNE* ; Spruth, E. J.DZNE* ; Beckmann, J.DZNE* ; Schneider, A.DZNE* ; Fliessbach, K.DZNE* ; Wiltfang, J.DZNE* ; Bartels, C. ; Rostamzadeh, A. ; Glanz, W.DZNE* ; Incesoy, E. I.DZNE* ; Teipel, S.DZNE* ; Kilimann, I.DZNE* ; Goerss, D.DZNE* ; Laske, C.DZNE* ; Spottke, A.DZNE* ; Kronmüller, M.DZNE* ; Brosseron, F.DZNE* ; Lüsebrink, F.DZNE* ; Schmid, M.DZNE* ; Kleineidam, L.DZNE* ; Stark, M.DZNE* ; Hetzer, S. ; Dechent, P. ; Jessen, F.DZNE* ; Maass, A.DZNE* ; Düzel, E. (Last author)DZNE* ; Ziegler, G. (Last author)DZNE*
Disruption of temporo-parietal network in Alzheimer's disease and its association with memory impairment.
Alzheimer's research & therapy 18(1), 166 (2026) [10.1186/s13195-026-02138-w]2026
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Grobe-Einsler, M. (First author)DZNE* ; Maas, V.DZNE* ; Amin, A. T.DZNE* ; Faber, J.DZNE* ; Schaprian, T.DZNE* ; Hill, K.DZNE* ; Synofzik, M.DZNE* ; Graf, L. H.DZNE* ; Jacobi, H. ; Lima, M. ; Ferreira, A. F. ; van de Warrenburg, B. P. ; Willemse, I. H. J. ; Timmann, D. ; Thieme, A. ; Giunti, P. ; Garcia-Moreno, H. ; Santana, M. M. ; Hübener-Schmid, J. ; Davies, E. H. ; Klockgether, T. (Last author)DZNE*
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points.
Annals of Clinical and Translational Neurology 13(7), 1370 - 1378 (2026) [10.1002/acn3.70316]2026
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Menze, I. (First author)DZNE* ; Bernal, J.DZNE* ; Kievit, R. A. ; Tripathi, K. P. ; Kaleck, T. ; Yakupov, R.DZNE* ; Altenstein, S.DZNE* ; Bartels, C. ; Buerger, K.DZNE* ; Butryn, M.DZNE* ; Dechent, P. ; Ewers, M.DZNE* ; Fliessbach, K.DZNE* ; Frommann, I.DZNE* ; Gemenetzi, M.DZNE* ; Glanz, W.DZNE* ; Gref, D.Extern* ; Hellmann-Regen, J. D. N.DZNE* ; Hetzer, S. ; Incesoy, E. I.DZNE* ; Janowitz, D.DZNE* ; Kilimann, I.DZNE* ; Kleineidam, L.DZNE* ; Kronmüller, M. T.DZNE* ; Laske, C.DZNE* ; van Lent, D. M. ; Lüsebrink, F.DZNE* ; Perneczky, R.DZNE* ; Peters, O.DZNE* ; Preis, L.Extern* ; Priller, J.DZNE* ; Rauchmann, B. S.Extern* ; Rostamzadeh, A. ; Roeske, S.DZNE* ; Scheffler, K. ; Schott, B.-H.DZNE* ; Schneider, A.DZNE* ; Sodenkamp, S.DZNE* ; Spottke, A.DZNE* ; Spruth, E. J.DZNE* ; Stark, M.DZNE* ; Teipel, S.DZNE* ; Wagner, M.DZNE* ; Wiltfang, J.DZNE* ; Jessen, F.DZNE* ; Ramirez, A.DZNE* ; Schreiber, S.DZNE* ; Düzel, E.DZNE* ; Ziegler, G. (Last author)DZNE*
Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.
Nature Communications 17(1), 5846 (2026) [10.1038/s41467-026-74957-2]2026
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All known publications ...
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