AG Spottke
Clinical Research Platform (CRP)
Also known as:AG Spottke; Clinical Research (Bonn); Clinical Research Platform - CRP; Clinical Trial Unit; Klinische Forschung (Bonn); Klinische Forschungsplattform; Klinische Forschungsstation
⇧ BN DZNE ⇧
Recent Publications
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Journal Article
Quattrone, A.Extern* ; Franzmeier, N. ; Huppertz, H.-J. ; et al
Brain Atrophy Does Not Predict Clinical Progression in Progressive Supranuclear Palsy.
Movement disorders 40(11), 2517 - 2530 (2025) [10.1002/mds.70026]2025
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Dörner, M. (First author)DZNE* ; Pfister, M. ; Tyndall, A. ; von Känel, R. ; Neumann, K.Extern* ; Schreiber, F.DZNE* ; Arndt, P.DZNE* ; Fuchs, E. ; Garz, C.DZNE* ; Glanz, W.DZNE* ; Butryn, M.DZNE* ; John, A.-C. ; Hildebrand, A. ; Euler, S. ; Hofmann, A. B. ; Machetanz, L. ; Kirchebner, J. ; Tacik, P.DZNE* ; Grimm, A. ; Jansen, R. ; Pawlitzki, M. ; Henneicke, S.DZNE* ; Perosa, V. ; Labeit, B. ; Düzel, E.DZNE* ; Meuth, S. G. ; Vielhaber, S.Extern* ; Mattern, H.DZNE* ; Bernal, J. (Last author)DZNE* ; Schreiber, S. (Last author)DZNE*
Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms.
Scientific reports 15(1), 2999 (2025) [10.1038/s41598-025-87493-8]2025
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Singh, D. (First author)DZNE* ; Brima, Y.DZNE* ; Levin, F.DZNE* ; Becker, M. ; Hiller, B. ; Hermann, A.DZNE* ; Villar-Munoz, I.DZNE* ; Beichert, L. ; Bernhardt, A.DZNE* ; Buerger, K.DZNE* ; Butryn, M.DZNE* ; Dechent, P. ; Düzel, E.DZNE* ; Ewers, M.DZNE* ; Fliessbach, K.DZNE* ; Freiesleben, S. D.DZNE* ; Glanz, W.DZNE* ; Hetzer, S. ; Janowitz, D.Extern* ; Görß, D.DZNE* ; Kilimann, I.DZNE* ; Kimmich, O.DZNE* ; Laske, C.DZNE* ; Levin, J.DZNE* ; Lohse, A. ; Luesebrink, F.DZNE* ; Munk, M.DZNE* ; Perneczky, R.DZNE* ; Peters, O.DZNE* ; Preis, L.Extern* ; Priller, J.DZNE* ; Prudlo, J.DZNE* ; Prychynenko, D.DZNE* ; Rauchmann, B. S.Extern* ; Rostamzadeh, A. ; Roy-Kluth, N.DZNE* ; Scheffler, K. ; Schneider, A.DZNE* ; Droste Zu Senden, L. ; Schott, B. H.DZNE* ; Spottke, A.DZNE* ; Synofzik, M.DZNE* ; Wiltfang, J.DZNE* ; Jessen, F.DZNE* ; Weber, M.-A. ; Teipel, S. J.DZNE* ; Dyrba, M. (Last author)DZNE*
An unsupervised XAI framework for dementia detection with context enrichment.
Scientific reports 15(1), 39554 (2025) [10.1038/s41598-025-26227-2]2025
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Parveen, K. ; Ross, J. A. ; van der Wurp, H. ; Balzer-Geldsetzer, M. ; Berg, D. ; Deuschl, G. ; Gasser, T.DZNE* ; Hilker-Roggendorf, R. ; Kalbe, E. ; Liepelt-Scarfone, I.DZNE* ; Mollenhauer, B.Extern* ; Riedel, O. ; Röske, S.DZNE* ; Schulz, J. B. ; Spottke, A.DZNE* ; Storch, A.DZNE* ; Trenkwalder, C. ; Kassubek, J.DZNE* ; Witt, K. ; Dodel, R. ; Wüllner, U.DZNE* ; Ramirez, A.DZNE* ; Dalmasso, M. C.
Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.
Journal of Parkinson's Disease 15(7), 1304 - 1311 (2025) [10.1177/1877718X251356512]2025
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Alexopoulou, Z.-S. ; Köhler, S.DZNE* ; Mallick, E. ; Tröger, J. ; Linz, N. ; Spruth, E.DZNE* ; Fliessbach, K.DZNE* ; Bartels, C. ; Rostamzadeh, A. ; Glanz, W.DZNE* ; Incesoy, E. I.DZNE* ; Butryn, M.DZNE* ; Kilimann, I.DZNE* ; Sodenkamp, S.DZNE* ; Munk, M. H.DZNE* ; Osterrath, A.DZNE* ; Esser, A.DZNE* ; Roeske, S.DZNE* ; Frommann, I.DZNE* ; Stark, M.DZNE* ; Kleineidam, L.DZNE* ; Spottke, A.DZNE* ; Priller, J.DZNE* ; Schneider, A.DZNE* ; Wiltfang, J.DZNE* ; Jessen, F.DZNE* ; Düzel, E.DZNE* ; Falkenburger, B.DZNE* ; Wagner, M.DZNE* ; Laske, C.DZNE* ; Manera, V. ; Teipel, S.DZNE* ; König, A.
Speech-based digital cognitive assessments for detection of mild cognitive impairment: Validation against paper-based neurocognitive assessment scores.
Journal of Alzheimer's disease 108(1_suppl), S118 - S131 (2025) [10.1177/13872877251343296]2025
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Singh, D. (First author)DZNE* ; Grazia, A.DZNE* ; Reiz, A. ; Hermann, A.DZNE* ; Altenstein, S.DZNE* ; Beichert, L. ; Bernhardt, A.DZNE* ; Buerger, K.DZNE* ; Butryn, M.DZNE* ; Dechent, P. ; Duezel, E.DZNE* ; Ewers, M.DZNE* ; Fliessbach, K.DZNE* ; Freiesleben, S. D.DZNE* ; Glanz, W.DZNE* ; Hetzer, S. ; Janowitz, D.Extern* ; Kilimann, I.DZNE* ; Kimmich, O.DZNE* ; Laske, C.DZNE* ; Levin, J.DZNE* ; Lohse, A. ; Lüsebrink-Rindsland, J. F. S.DZNE* ; Munk, M.DZNE* ; Perneczky, R.DZNE* ; Peters, O.DZNE* ; Preis, L.Extern* ; Priller, J.DZNE* ; Prudlo, J.DZNE* ; Rauchmann, B. S.Extern* ; Rostamzadeh, A. ; Roy-Kluth, N.DZNE* ; Scheffler, K. ; Schneider, A.DZNE* ; Schneider, L.-S.Extern* ; Schott, B. H.DZNE* ; Spottke, A.DZNE* ; Spruth, E. J.DZNE* ; Synofzik, M.DZNE* ; Wiltfang, J.DZNE* ; Jessen, F.DZNE* ; Teipel, S. J.DZNE* ; Dyrba, M. (Last author)DZNE* ; ADNI (Collaboration Author) ; AIBL (Collaboration Author) ; FTLDNI (Collaboration Author) ; groups, s. (Collaboration Author)
A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans.
Journal of Alzheimer's disease 108(1_suppl), S258 - S273 (2025) [10.1177/13872877251331222]2025
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Hermann, A. (First author)DZNE* ; Prudlo, J.DZNE* ; Kasper, E.Extern* ; Synofzik, M.DZNE* ; Peters, O.DZNE* ; Priller, J.DZNE* ; Dinter, E.DZNE* ; Wiltfang, J.DZNE* ; Zerr, I.DZNE* ; Flöel, A.DZNE* ; Bürger, K.DZNE* ; Höglinger, G. U.DZNE* ; Levin, J.DZNE* ; Düzel, E.DZNE* ; Teipel, S.DZNE* ; Beichert, L.DZNE* ; Brosseron, F.DZNE* ; Wagner, M.DZNE* ; Frommann, I.DZNE* ; Ramirez, A.DZNE* ; Yakupov, R.DZNE* ; Schmid, M.DZNE* ; Lingor, P.DZNE* ; Haass, C.DZNE* ; DESCRIBE-ALS ; consortium, D.-F. (Collaboration Author) ; Spottke, A.DZNE* ; Günther, R.DZNE* ; Weydt, P.DZNE* ; Neumann, M.DZNE* ; Schneider, A. (Last author)DZNE*
'The DESCRIBE-ALS-FTD study: a prospective multicenter observational study of the ALS-FTD spectrum'.
Amyotrophic lateral sclerosis & frontotemporal degeneration 26(7-8), 720 - 728 (2025) [10.1080/21678421.2025.2509617]2025
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Leone, R. (First author)DZNE* ; Kobeleva, X. (Last author)DZNE* ; Initiative, A. D. N. (Collaboration Author)
White matter hyperintensities contribute to early cortical thinning in addition to tau in aging.
Neurobiology of aging 155, 66 - 77 (2025) [10.1016/j.neurobiolaging.2025.07.007]2025
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Nemali, A. (First author)DZNE* ; Bernal, J.DZNE* ; Yakupov, R.DZNE* ; Singh, D.DZNE* ; Dyrba, M.DZNE* ; Incesoy, E. I.DZNE* ; Mukherjee, S.DZNE* ; Peters, O.DZNE* ; Ersözlü, E.DZNE* ; Hellmann-Regen, J.DZNE* ; Preis, L.Extern* ; Priller, J.DZNE* ; Spruth, E. J.DZNE* ; Altenstein, S.DZNE* ; Lohse, A. ; Schneider, A.DZNE* ; Fliessbach, K.DZNE* ; Kimmich, O.DZNE* ; Wiltfang, J.DZNE* ; Hansen, N. ; Schott, B.DZNE* ; Rostamzadeh, A. ; Glanz, W.DZNE* ; Butryn, M.DZNE* ; Buerger, K.DZNE* ; Janowitz, D.Extern* ; Ewers, M. ; Perneczky, R.DZNE* ; Rauchmann, B. S.Extern* ; Teipel, S.DZNE* ; Kilimann, I.DZNE* ; Goerss, D.DZNE* ; Laske, C.DZNE* ; Sodenkamp, S.DZNE* ; Spottke, A.DZNE* ; Coenjaerts, M.DZNE* ; Brosseron, F.DZNE* ; Lüsebrink, F.DZNE* ; Dechent, P. ; Scheffler, K. ; Hetzer, S. ; Kleineidam, L.DZNE* ; Stark, M. ; Jessen, F.DZNE* ; Duzel, E.DZNE* ; Ziegler, G. (Last author)DZNE*
SMAS: Structural MRI-based AD Score using Bayesian supervised VAE.
Computers in biology and medicine 196(Pt C), 110829 (2025) [10.1016/j.compbiomed.2025.110829]2025
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Li, Q.Extern* ; Koehler, S.DZNE* ; Koenig, A. ; Dyrba, M.DZNE* ; Mallik, E. ; Linz, N. ; Priller, J.DZNE* ; Spruth, E. J.DZNE* ; Altenstein, S.DZNE* ; Wiltfang, J.DZNE* ; Zerr, I.DZNE* ; Bartels, C. ; Maier, F. ; Rostamzadeh, A. ; Duezel, E.DZNE* ; Glanz, W.DZNE* ; Incesoy, E. I.DZNE* ; Butryn, M.DZNE* ; Laske, C.DZNE* ; Sodenkamp, S.DZNE* ; Munk, M. H.DZNE* ; Falkenburger, B.DZNE* ; Osterrath, A.DZNE* ; Kilimann, I.DZNE* ; Stark, M.DZNE* ; Kleineidam, L.DZNE* ; Heneka, M. T. ; Spottke, A.DZNE* ; Wagner, M.DZNE* ; Jessen, F.DZNE* ; Petzold, G. C.DZNE* ; Levin, F.DZNE* ; Teipel, S. (Last author)DZNE*
Associations between digital speech features of automated cognitive tasks and trajectories of brain atrophy and cognitive decline in early Alzheimer's disease.
Journal of Alzheimer's disease 107(1), 154 - 169 (2025) [10.1177/13872877251359967]2025
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All known publications ...
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