AG Spottke
Clinical Research Platform (CRP)
Also known as:AG Spottke; Clinical Research (Bonn); Clinical Research Platform - CRP; Clinical Trial Unit; Klinische Forschung (Bonn); Klinische Forschungsplattform; Klinische Forschungsstation
⇧ BN DZNE ⇧
Recent Publications
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Journal Article
Dörner, M. (First author)DZNE* ; Pfister, M. ; Tyndall, A. ; von Känel, R. ; Neumann, K.Extern* ; Schreiber, F.DZNE* ; Arndt, P.DZNE* ; Fuchs, E. ; Garz, C.DZNE* ; Glanz, W.DZNE* ; Butryn, M.DZNE* ; John, A.-C. ; Hildebrand, A. ; Euler, S. ; Hofmann, A. B. ; Machetanz, L. ; Kirchebner, J. ; Tacik, P.DZNE* ; Grimm, A. ; Jansen, R. ; Pawlitzki, M. ; Henneicke, S.DZNE* ; Perosa, V. ; Labeit, B. ; Düzel, E.DZNE* ; Meuth, S. G. ; Vielhaber, S.Extern* ; Mattern, H.DZNE* ; Bernal, J. (Last author)DZNE* ; Schreiber, S. (Last author)DZNE*
Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms.
Scientific reports 15(1), 2999 (2025) [10.1038/s41598-025-87493-8]2025
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Leone, R. (First author)DZNE* ; Kobeleva, X. (Last author)DZNE* ; Initiative, A. D. N. (Collaboration Author)
White matter hyperintensities contribute to early cortical thinning in addition to tau in aging.
Neurobiology of aging 155, 66 - 77 (2025) [10.1016/j.neurobiolaging.2025.07.007]2025
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Nemali, A. (First author)DZNE* ; Bernal, J.DZNE* ; Yakupov, R.DZNE* ; Singh, D.DZNE* ; Dyrba, M.DZNE* ; Incesoy, E. I.DZNE* ; Mukherjee, S.DZNE* ; Peters, O.DZNE* ; Ersözlü, E.DZNE* ; Hellmann-Regen, J.DZNE* ; Preis, L.Extern* ; Priller, J.DZNE* ; Spruth, E. J.DZNE* ; Altenstein, S.DZNE* ; Lohse, A. ; Schneider, A.DZNE* ; Fliessbach, K.DZNE* ; Kimmich, O.DZNE* ; Wiltfang, J.DZNE* ; Hansen, N. ; Schott, B.DZNE* ; Rostamzadeh, A. ; Glanz, W.DZNE* ; Butryn, M.DZNE* ; Buerger, K.DZNE* ; Janowitz, D.Extern* ; Ewers, M. ; Perneczky, R.DZNE* ; Rauchmann, B. S.Extern* ; Teipel, S.DZNE* ; Kilimann, I.DZNE* ; Goerss, D.DZNE* ; Laske, C.DZNE* ; Sodenkamp, S.DZNE* ; Spottke, A.DZNE* ; Coenjaerts, M.DZNE* ; Brosseron, F.DZNE* ; Lüsebrink, F.DZNE* ; Dechent, P. ; Scheffler, K. ; Hetzer, S. ; Kleineidam, L.DZNE* ; Stark, M. ; Jessen, F.DZNE* ; Duzel, E.DZNE* ; Ziegler, G. (Last author)DZNE*
SMAS: Structural MRI-based AD Score using Bayesian supervised VAE.
Computers in biology and medicine 196(Pt C), 110829 (2025) [10.1016/j.compbiomed.2025.110829]2025
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Li, Q.Extern* ; Koehler, S.DZNE* ; Koenig, A. ; Dyrba, M.DZNE* ; Mallik, E. ; Linz, N. ; Priller, J.DZNE* ; Spruth, E. J.DZNE* ; Altenstein, S.DZNE* ; Wiltfang, J.DZNE* ; Zerr, I.DZNE* ; Bartels, C. ; Maier, F. ; Rostamzadeh, A. ; Duezel, E.DZNE* ; Glanz, W.DZNE* ; Incesoy, E. I.DZNE* ; Butryn, M.DZNE* ; Laske, C.DZNE* ; Sodenkamp, S.DZNE* ; Munk, M. H.DZNE* ; Falkenburger, B.DZNE* ; Osterrath, A.DZNE* ; Kilimann, I.DZNE* ; Stark, M.DZNE* ; Kleineidam, L.DZNE* ; Heneka, M. T. ; Spottke, A.DZNE* ; Wagner, M.DZNE* ; Jessen, F.DZNE* ; Petzold, G. C.DZNE* ; Levin, F.DZNE* ; Teipel, S. (Last author)DZNE*
Associations between digital speech features of automated cognitive tasks and trajectories of brain atrophy and cognitive decline in early Alzheimer's disease.
Journal of Alzheimer's disease 107(1), 154 - 169 (2025) [10.1177/13872877251359967]2025
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Glaeser, E. (First author)DZNE* ; Kilimann, I.DZNE* ; Platen, M.DZNE* ; Hoffmann, W.DZNE* ; Brosseron, F.DZNE* ; Buerger, K.DZNE* ; Coenjaerts, M.DZNE* ; Düzel, E.DZNE* ; Ewers, M.DZNE* ; Fliessbach, K.DZNE* ; Frommann, I.DZNE* ; Gemenetzi, M.DZNE* ; Glanz, W.DZNE* ; Hellmann-Regen, J.DZNE* ; Incesoy, E. I.DZNE* ; Janowitz, D.Extern* ; Jessen, F.DZNE* ; Peters, O.DZNE* ; Priller, J.DZNE* ; Ramirez, A.DZNE* ; Schneider, A.DZNE* ; Spottke, A.DZNE* ; Spruth, E. J.DZNE* ; Teipel, S.DZNE* ; Wagner, M.DZNE* ; Michalowsky, B. (Last author)DZNE*
The economic burden of subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia: excess costs and associated clinical and risk factors.
Alzheimer's research & therapy 17(1), 142 (2025) [10.1186/s13195-025-01785-9]2025
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Bartels, C. ; Tzu-Yueh Chen, J. ; Belz, M. ; Yakupov, R.DZNE* ; Düzel, E.DZNE* ; Glanz, W.DZNE* ; Lüsebrink, F.DZNE* ; Dechent, P. ; Kleineidam, L.DZNE* ; Stark, M.Extern* ; Spottke, A.DZNE* ; Coenjaerts, M.DZNE* ; Fließbach, K.DZNE* ; Schneider, A.DZNE* ; Rostamzadeh, A. ; Jessen, F.DZNE* ; Schott, B.DZNE* ; Wiltfang, J.DZNE* ; Frommann, I.DZNE* ; Wagner, M.DZNE* ; Goya-Maldonado, R.
Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia.
Alzheimer's research & therapy 17(1), 195 (2025) [10.1186/s13195-025-01833-4]2025
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Kobeleva, X.DZNE* ; Rowe, B. ; Choupan, J. ; Ringman, J. M. ; Barisano, G. ; Leone, R. (First author)DZNE*
Alterations in MRI-visible perivascular spaces precede dementia diagnosis by 18 years in autosomal dominant Alzheimer's disease.
Alzheimer's and dementia 21(8), e70588 (2025) [10.1002/alz.70588]2025
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Baumeister, H. (First author)DZNE* ; Gellersen, H. M.DZNE* ; Polk, S. E.DZNE* ; et al
Disease stage-specific atrophy markers in Alzheimer's disease.
Alzheimer's and dementia 21(7), e70482 (2025) [10.1002/alz.70482]2025
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Berger, M. ; Garcia-Moreno, H. ; Ferreira, M.DZNE* ; et al
Progression of biological markers in spinocerebellar ataxia type 3: longitudinal analysis of prospective data from the ESMI cohort.
The lancet / Regional health. Europe 55, 101339 (2025) [10.1016/j.lanepe.2025.101339]2025
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Mengel, D. (First author)DZNE* ; Soter, E. ; Ott, J. M. ; Wacker, M.Extern* ; Leyva, A. ; Peters, O.DZNE* ; Hellmann-Regen, J. D. N.DZNE* ; Schneider, L.-S.DZNE* ; Wang, X. ; Priller, J.DZNE* ; Spruth, E. J.DZNE* ; Altenstein, S.DZNE* ; Schneider, A.DZNE* ; Fliessbach, K.DZNE* ; Wiltfang, J.DZNE* ; Hansen, N. ; Rostamzadeh, A. ; Düzel, E.DZNE* ; Glanz, W.DZNE* ; Incesoy, E. I.DZNE* ; Buerger, K.DZNE* ; Janowitz, D.DZNE* ; Ewers, M.DZNE* ; Perneczky, R.DZNE* ; Rauchmann, B. S.Extern* ; Teipel, S.DZNE* ; Kilimann, I.DZNE* ; Laske, C.DZNE* ; Sodenkamp, S.DZNE* ; Spottke, A.DZNE* ; Brustkern, J.DZNE* ; Brosseron, F.DZNE* ; Wagner, M.DZNE* ; Stark, M.DZNE* ; Kleineidam, L.DZNE* ; Shao, K.DZNE* ; Lüsebrink, F.DZNE* ; Yakupov, R.DZNE* ; Schmid, M.DZNE* ; Hetzer, S. ; Dechent, P. ; Scheffler, K. ; Berron, D.DZNE* ; Jessen, F.DZNE* ; Synofzik, M.DZNE* ; group, D. s. (Collaboration Author)
Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease.
Molecular psychiatry 30(7), 3150 - 3159 (2025) [10.1038/s41380-025-03021-0]2025
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All known publications ...
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