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@ARTICLE{Rmer:135987,
      author       = {Römer, Benedikt and Krebs, Julia and Overall, Rupert W and
                      Fabel, Klaus and Babu, Harish and Overstreet-Wadiche, Linda
                      and Brandt, Moritz D and Williams, Robert W and Jessberger,
                      Sebastian and Kempermann, Gerd},
      title        = {{A}dult hippocampal neurogenesis and plasticity in the
                      infrapyramidal bundle of the mossy fiber projection: {I}.
                      {C}o-regulation by activity.},
      journal      = {Frontiers in neuroscience},
      volume       = {5},
      issn         = {1662-453X},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2020-02309},
      pages        = {107},
      year         = {2011},
      abstract     = {BESIDES THE MASSIVE PLASTICITY AT THE LEVEL OF SYNAPSES, WE
                      FIND IN THE HIPPOCAMPUS OF ADULT MICE AND RATS TWO SYSTEMS
                      WITH VERY STRONG MACROSCOPIC STRUCTURAL PLASTICITY: adult
                      neurogenesis, that is the lifelong generation of new granule
                      cells, and dynamic changes in the mossy fibers linking the
                      dentate gyrus to area CA3. In particular the anatomy of the
                      infrapyramidal mossy fiber tract (IMF) changes in response
                      to a variety of extrinsic and intrinsic stimuli. Because
                      mossy fibers are the axons of granule cells, the question
                      arises whether these two types of plasticity are linked.
                      Using immunohistochemistry for markers associated with
                      axonal growth and pro-opiomelanocortin (POMC)-GFP mice to
                      visualize the post-mitotic maturation phase of adult
                      hippocampal neurogenesis, we found that newly generated
                      mossy fibers preferentially but not exclusively contribute
                      to the IMF. The neurogenic stimulus of an enriched
                      environment increased the volume of the IMF. In addition,
                      the IMF grew with a time course consistent with axonal
                      outgrowth from the newborn neurons after the induction of
                      neurogenic seizures using kainate. These results indicate
                      that two aspects of plasticity in the adult hippocampus,
                      mossy fiber size and neurogenesis, are related and may share
                      underlying mechanisms. In a second part of this study,
                      published separately (Krebs et al., 2011) we have addressed
                      the question of whether there is a shared genetics
                      underlying both traits.},
      cin          = {Dresden Pre 2020 / AG Kempermann 1},
      ddc          = {610},
      cid          = {I:(DE-2719)6000013 / I:(DE-2719)1710001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21991243},
      pmc          = {pmc:PMC3180604},
      doi          = {10.3389/fnins.2011.00107},
      url          = {https://pub.dzne.de/record/135987},
}