Publications Database

Background: To provide Person-Centered Care (PCC) for People with Dementia (PwD), patient’s stated preferences must be known. Data about stated care-preferences among PwD are limited. [...]

This volume provides readers with a detailed collection of in vitro and in vivo protocols developed to study inflammation and the interactions between host and micro-organisms. The chapters in this book cover a range of biological systems and methodological approaches such as direct inoculation of pathogenic yeasts into mouse lung by trans-tracheal instillation; murine models of experimental periodontal disease; quantitative in vitro and in vivo assays to assess the efferocytic efficiency of macrophages; murine models of alphavirus infection to study the immunopathogenesis of pain; and in vivo preclinical platforms to study coronavirus infection. [...]

The β-secretase BACE1 (β-site amyloid precursor (APP) cleaving enzyme 1) is a major drug target for Alzheimer's disease (AD), as it catalyzes the first step in amyloid β (Aβ) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical trials with BACE1 inhibitors were stopped because of an adverse event, a mild cognitive worsening. [...]

Spatial biology has emerged as a pivotal area in many life science fields, with mass spectrometry imaging (MSI) becoming a cornerstone for molecular imaging. Among recent advancements to increase sensitivity, MALDI-2 technology has significantly expanded the molecular space accessible to MSI, increasing the ion yields of neutral metabolites, such as sterols. [...]

Immune checkpoint inhibitors (ICI) and chimeric antigen receptor T‑cell (CAR-T) therapies have fundamentally transformed oncology. With their increasing use, immune-related adverse events (irAEs) have gained attention, including those affecting the nervous system.To describe the clinical and imaging characteristics of neurological immune-related adverse events (NirAEs) under ICI and CAR‑T therapy, as well as their differential diagnostic and therapeutic implications.Review of current literature on the incidence, clinical spectrum, and imaging features of NirAEs.NirAEs occur in approximately 1-6% of patients treated with ICIs. [...]

Glioblastoma (GBM) is a devastating brain tumor with limited treatment success, partly because in vitro models poorly mimic in vivo complexity. This study introduces a high-throughput 3D culture platform utilizing modular starPEG–glycosaminoglycan (GAG) hydrogels that enable independent control of extracellular matrix (ECM) cues: stiffness, cytokine affinity, matrix metalloproteinase-responsive remodeling, and cell adhesiveness via integrin-binding RGD peptides. [...]

There is a wide treatment heterogeneity for asphyxiated newborn infants between hospitals in Germany. This study aimed to identify the leading entry criteria initiating therapeutic hypothermia (TH) using data from the German Hypothermia Registry.We retrospectively analyzed 262 asphyxiated newborn infants treated with TH across 74 neonatal units in Germany. [...]

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, with both genetic and environmental risk factors. While traditionally, a relapsing and progressive disease course has been distinguished, it has increasingly become evident that elements of progression are the dominant factor for accumulating MS-related neurologic disability across all clinical courses and can be detected throughout the full disease trajectory in patients with MS. [...]

Motor performance (MP) is essential for maintaining functional independence, particularly in later life. However, the relationship between MP and sleep quality, depressive symptoms, and their underlying brain substrates remains obscure. [...]