Publications Database

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2025-05-22
15:23
[DZNE-2025-00630] Contribution to a conference proceedings/Contribution to a book
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Preface
Patch-Based Techniques in Medical Imaging / Bai, Wenjia (Editor) ; Cham : Springer International Publishing, 2018, ; ISSN: 0302-9743=1611-3349 ; ISBN: 978-3-030-00499-6=978-3-030-00500-9 ; doi:10.1007/978-3-030-00500-9
Patch-Based Techniques in Medical Imaging, Patch-MI 2018, GranadaGranada, Spain, 20 Sep 2018 - 20 Sep 20182018-09-202018-09-20
Cham : Springer International Publishing, Lecture Notes in Computer Science 11075, V - VI ()
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2025-05-16
09:38
OpenAccess [DZNE-2025-00614] Journal Article
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RAB5 is a host dependency factor for the generation of SARS-CoV-2 replication organelles.
mBio 16(5), e0331424 () [10.1128/mbio.03314-24]
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a threat due to the emergence of variants with increased transmissibility and enhanced escape from immune responses. Like other coronaviruses before, SARS-CoV-2 likely emerged after its transmission from bats. [...]

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2025-05-16
09:36
OpenAccess [DZNE-2025-00613] Journal Article
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Intermittent fasting reduces alpha-synuclein pathology and functional decline in a mouse model of Parkinson's disease.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein (aSyn) accumulation. Environmental factors play a significant role in PD progression, highlighting the potential of non-pharmacological interventions. [...]

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2025-05-16
09:30
OpenAccess [DZNE-2025-00612] Journal Article
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Fully automated MRI-based analysis of the locus coeruleus in aging and Alzheimer's disease dementia using ELSI-Net.
The locus coeruleus (LC) is linked to the development and pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). Magnetic resonance imaging-based LC features have shown potential to assess LC integrity in vivo.We present a deep learning-based LC segmentation and feature extraction method called Ensemble-based Locus Coeruleus Segmentation Network (ELSI-Net) and apply it to healthy aging and AD dementia datasets. [...]
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2025-05-16
09:25
OpenAccess [DZNE-2025-00611] Journal Article
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Serum glial fibrillary protein reflects early brain injury dynamics and cognitive changes after deep brain stimulation surgery.
Deep brain stimulation (DBS) is an efficient treatment for movement disorders, most commonly Parkinson's Disease (PD), dystonia and essential tremor. DBS surgery carries risks, e.g. [...]

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2025-05-16
09:24
OpenAccess [DZNE-2025-00610] Journal Article
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TRIM23 mediates cGAS-induced autophagy in anti-HSV defense.
The cGAS-STING pathway, well-known to elicit interferon (IFN) responses, is also a key inducer of autophagy upon virus infection or other stimuli. Whereas the mediators for cGAS-induced IFN responses are well characterized, much less is known about how cGAS elicits autophagy. [...]

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2025-05-15
12:48
OpenAccess [DZNE-2025-00609] Journal Article
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Lead as an environmental toxicant in models of synucleinopathies.
Lead, a toxic heavy metal, is prevalent in various industrial applications, contributing to environmental contamination and significant health concerns. Lead affects various body systems, especially the brain, causing long-lasting cognitive and behavioral changes. [...]
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2025-05-15
10:31
[DZNE-2025-00607] Dissertation / PhD Thesis

Identification of compensatory mechanisms and disease pathways in mitochondrial disease and synucleinopathy
97 p. () = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2025
Mitochondria play vital roles in a variety of processes such as cellular metabolism, intracellular signalling and cell death. Defects in mitochondria can lead to inherited metabolic disorders and neurodegenerative diseases. [...]
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2025-05-15
09:53
DBCoverage [DZNE-2025-00606] Journal Article
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Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling.
EMBO reports 26(9), 2232 - 2261 () [10.1038/s44319-025-00423-7]
Tight control of cGAS-STING-mediated DNA sensing is crucial to avoid auto-inflammation. The GTPase ADP-ribosylation factor 1 (ARF1) is crucial to maintain cGAS-STING homeostasis and various pathogenic ARF1 variants are associated with type I interferonopathies. [...]

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2025-05-15
09:51
[DZNE-2025-00605] Journal Article (Review Article)
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Versatile MRI acquisition and processing protocol for population-based neuroimaging.
Nature protocols 20(5), 1223 - 1245 () [10.1038/s41596-024-01085-w]
Neuroimaging has an essential role in studies of brain health and of cerebrovascular and neurodegenerative diseases, requiring the availability of versatile magnetic resonance imaging (MRI) acquisition and processing protocols. We designed and developed a multipurpose high-resolution MRI protocol for large-scale and long-term population neuroimaging studies that includes structural, diffusion-weighted and functional MRI modalities. [...]
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