Publications Database

Microglia, the resident immune cells of the brain, play a complex role in health and disease. They actively survey the brain parenchyma by physically interacting with other cells and structurally shaping the brain. [...]

Tauopathies, such as Alzheimer’s disease and Frontotemporal Dementia, are common neurodegenerative diseases characterized by misfolding, hyperphosphorylation, and aggregation of Tau. Molecular mechanisms underlying Tauopathies are still poorly understood, in part due to a lack of human models endogenously developing major disease hallmarks. [...]

Supplemental material for manuscript submitted to Current Biology, 2017..

Here we provide raw data and graphpad prism analysis on the animal studies, western blot, histology and ELISpot published in 'Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells.' Reincke et al

The goal of the current work was to analyze and validate metabolic regional network alterations in three different AD mouse models (β-amyloid and tau) by use of 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography (FDG-PET) imaging. We compared the results of FDG-µPET MC with conventional VOI-based analysis and behavioral assessment in the Morris water maze (MWM). [...]

Supplementary tables for Frishberg et al. 2022 (Cell Reports Medicine)...

- APNU 1.1 and 2.0 Fiji scripts and Licences - pdf files with a EJN paper to be cited using APNU 1.1 and a Cells paper to be cited using APNU 2.0 - Two raw images of PNNs in control and ketamine-treated rats (any can be selected after running the Fiji script, zoomed, and used for selection of PNN units) - Traced PNN units in control and ketamine-treated rats (can be opened in Fiji) - Exel file with all measured PNN units (group 1 is control, group 2 is Ketamine), all cells, all animals, all analyses

Supplemental tables of the publication 'Early IFN-a signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19' Benjamin Krämer et al., 2021. Sup. [...]

The data set includes original gel corresponding to Figure 1B and all measurements and statistical analyses used for other figures in the aforementioned article by Nikita Arnst, Pedro Belio-Maira, Laura García-González, Laurie Arnaud, Louise Greetham, Emmanuel Nivet, Santiago Rivera and Alexander Dityatev. We found that MT5-MMP-deficient neurons exhibited an increased number of primary and secondary neurites, as compared to isogenic hiPSC-derived neurons. [...]

The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019 (COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed characterization of virus-neutralizing antibodies and target epitopes is needed to understand COVID-19 pathophysiology and guide immunization strategies. [...]