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2024-06-06
09:25
OpenAccess [DZNE-2024-00736] Journal Article
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Systematic evaluation of fMRI data-processing pipelines for consistent functional connectomics.
Functional interactions between brain regions can be viewed as a network, enabling neuroscientists to investigate brain function through network science. Here, we systematically evaluate 768 data-processing pipelines for network reconstruction from resting-state functional MRI, evaluating the effect of brain parcellation, connectivity definition, and global signal regression. [...]
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2024-06-03
09:05
OpenAccess [DZNE-2024-00691] Journal Article
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EANM practice guidelines for an appropriate use of PET and SPECT for patients with epilepsy.
Epilepsy is one of the most frequent neurological conditions with an estimated prevalence of more than 50 million people worldwide and an annual incidence of two million. Although pharmacotherapy with anti-seizure medication (ASM) is the treatment of choice, ~30% of patients with epilepsy do not respond to ASM and become drug resistant. [...]
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2024-06-03
09:03
OpenAccess [DZNE-2024-00690] Journal Article
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Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies.
We hypothesized that severe tau burden in brain regions involved in direct or indirect pathways of the basal ganglia correlate with more severe striatal dopamine deficiency in four-repeat (4R) tauopathies. Therefore, we correlated [18F]PI-2620 tau-positron-emission-tomography (PET) imaging with [123I]-Ioflupane single-photon-emission-computed tomography (SPECT) for dopamine transporter (DaT) availability.Thirty-eight patients with clinically diagnosed 4R-tauopathies (21 male; 69.0 ± 8.5 years) and 15 patients with clinically diagnosed α-synucleinopathies (8 male; 66.1 ± 10.3 years) who underwent [18F]PI-2620 tau-PET and DaT-SPECT imaging with a time gap of 3 ± 5 months were evaluated. [...]
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2024-06-03
08:59
OpenAccess [DZNE-2024-00689] Journal Article
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Spatiotemporal sphingosine-1-phosphate receptor 3 expression within the cerebral vasculature after ischemic stroke
iScience 27(6), 110031 () [10.1016/j.isci.2024.110031]
Sphingosine-1-phosphate receptors (S1PRs) are promising therapeutic targets in cardiovascular disease, including ischemic stroke. However, important spatiotemporal information for alterations of S1PR expression is lacking. [...]
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2024-06-03
08:57
OpenAccess [DZNE-2024-00688] Journal Article
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Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance
Cell reports 43(6), 114276 () [10.1016/j.celrep.2024.114276]
How the coordination of neuronal spiking and brain rhythms between hippocampal subregions supports memory function remains elusive. We studied the interregional coordination of CA3 neuronal spiking with CA1 theta oscillations by recording electrophysiological signals along the proximodistal axis of the hippocampus in rats that were performing a high-memory-demand recognition memory task adapted from humans. [...]
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2024-06-03
08:55
OpenAccess [DZNE-2024-00687] Journal Article
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Impact of gene-by-trauma interaction in MDD-related multimorbidity clusters
Background: Major depressive disorder (MDD) is considerably heterogeneous in terms of comorbidities, which may hamper the disentanglement of its biological mechanism. In a previous study, we classified the lifetime trajectories of MDD-related multimorbidities into seven distinct clusters, each characterized by unique genetic and environmental risk-factor profiles. [...]
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2024-05-31
11:09
OpenAccess [DZNE-2024-00684] Journal Article
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Combined treatment with allogeneic Epstein-Barr- and human polyomavirus 1 specific T-cells in progressive multifocal leukoencephalopathy and EBV infection: a case report.
Opportunistic viral infections in individuals with severe immunodeficiency can lead to fatal conditions such as progressive multifocal leukoencephalopathy (PML), for which treatment options are limited. These infections pose significant risks, especially when co-infections with other viruses occur. [...]
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2024-05-31
11:07

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2024-05-31
11:02
OpenAccess [DZNE-2024-00682] Journal Article
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Long-term safety, tolerability and efficacy of apomorphine sublingual film in patients with Parkinson's disease complicated by OFF episodes: a phase 3, open-label study.
Journal of neurology 271(6), 3554 - 3570 () [10.1007/s00415-024-12323-2]
Apomorphine sublingual film (SL-APO) is an on-demand treatment for OFF episodes in patients with Parkinson's disease (PD).To assess the long-term (≥ 3 years) safety/tolerability and efficacy of SL-APO.Study CTH-301 ( http://www.gov NCT02542696; registered 2015-09-03) was a phase 3, multicentre, open-label study of SL-APO in PD patients with motor fluctuations, comprised of a dose-titration and long-term safety phase. All participants received SL-APO. [...]
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2024-05-29
14:45
[DZNE-2024-00669] Preprint
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Circulating microRNAs are related to cognitive domains in the general population
INTRODUCTION: Circulating microRNAs have been suggested as candidates for detecting and preventing subclinical cognitive dysfunction. However, replication of previous findings and identification of novel microRNAs associated with cognitive domains, including their relation to brain structure and the pathways they regulate, are still lacking.METHODS: We examined circulating microRNAs and microRNA co-expression clusters in relation to cognitive domains, structural MRI measures, and target gene expression in 2869 participants of a population-based cohort.RESULTS: Five previously identified and 10 novel microRNAs were associated with cognitive domains. [...]

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