Publications database

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2021-11-30
11:54
pmc [DZNE-2021-01590] Journal Article
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Neurological symptoms and complications in predominantly hospitalized COVID-19 patients: Results of the European multinational Lean European Open Survey on SARS-Infected Patients (LEOSS).
European journal of neurology 28(12), 3925 - 3937 () [10.1111/ene.15072]
During acute coronavirus disease 2019 (COVID-19) infection, neurological signs, symptoms and complications occur. We aimed to assess their clinical relevance by evaluating real-world data from a multinational registry.We analyzed COVID-19 patients from 127 centers, diagnosed between January 2020 and February 2021, and registered in the European multinational LEOSS (Lean European Open Survey on SARS-Infected Patients) registry. [...]
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2021-11-30
11:50
DBCoverage [DZNE-2021-01589] Journal Article
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Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation.
Theranostics 11(18), 8964 - 8976 () [10.7150/thno.64022]
Modulation of the innate immune system is emerging as a promising therapeutic strategy against Alzheimer's disease (AD). However, determinants of a beneficial therapeutic effect are ill-understood. [...]
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2021-11-30
11:44
[DZNE-2021-01588] Journal Article
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Blood Neurofilament Light Chain in Genetic Ataxia: A Meta-Analysis.
Movement disorders 37(1), 171-181 () [10.1002/mds.28783]
No comprehensive meta-analysis has ever been performed to assess the value of neurofilament light chain (NfL) as a biomarker in genetic ataxia.We conducted a meta-analysis to summarize NfL concentration and evaluate its utility as a biomarker in genetic ataxia.Studies were included if they reported NfL concentration of genetic ataxia. We used log (mean ± SD) NfL to describe mean raw value of NfL. [...]

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2021-11-30
11:41
[DZNE-2021-01587] Journal Article
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Validation of a social deprivation index and association with cognitive function and decline in older adults.
Previous work using a US sample has shown that an index of social deprivation (SoDep Index) is associated with cognitive functioning and decline in older adults. This study aimed to replicate these findings using a European sample (Survey of Health, Ageing and Retirement in Europe, SHARE).We analyzed data of 51,630 respondents aged 50 years and older (M: 63.5 years, standard deviation [SD]: 9.1) with at least two cognitive assessments (follow-up M: 6.06 years, SD: 3.86). [...]

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2021-11-30
11:33
[DZNE-2021-01586] Journal Article
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Microvascular Breakdown Due to Retinal Neurodegeneration in Ataxias.
Movement disorders 37(1), 162-170 () [10.1002/mds.28791]
Neurodegenerative ataxias are devastating disorders of the cerebellum and spinal cord, accompanied by death of retinal ganglion cells, leading to relentlessly progressive decline of motor coordination and permanent disability. Retinal microvascular affection has not yet been determined.The aim of this study is to assess whether retinal microvascular alterations occur and, if so, whether they are concurrent with or follow cell death in the retina in neurodegenerative diseases.This study involves the cross-sectional observational study of 43 patients with ataxia and 43 controls enrolled from August 1, 2018, to September 30, 2020. [...]
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2021-11-30
11:27
[DZNE-2021-01585] Journal Article
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Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk.
Movement disorders 37(1), 95-105 () [10.1002/mds.28787]
The leucine-rich repeat kinase 2 (LRRK2) gene harbors both rare highly damaging missense variants (eg, p.G2019S) and common noncoding variants (eg, rs76904798) with lower effect sizes that are associated with Parkinson's disease (PD) risk.This study aimed to investigate in a large meta-analysis whether the LRRK2 Genome-Wide Association Study (GWAS) signal represented by rs76904798 is independently associated with PD risk from LRRK2 coding variation and whether complex linkage disequilibrium structures with p.G2019S and the 5' noncoding haplotype account for the association of LRRK2 coding variants.We performed a meta-analysis using imputed genotypes from 17,838 patients, 13,404 proxy patients, and 173,639 healthy controls of European ancestry. We excluded carriers of p.G2019S and/or rs76904798 to clarify the role of LRRK2 coding variation in mediating disease risk and excluded carriers of relatively rare LRRK2 coding variants to assess the independence of rs76904798. [...]
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2021-11-29
13:02
[DZNE-2021-01584] Journal Article
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Covid-19-Pandemie: Angsterleben von niedergelassenen und Krankenhaus-Psychiatern.
To date, no studies have examined the pandemic-related stress experience of inpatient versus outpatient psychiatrists. Therefore, the aim is to investigate the extent of Covid-19 exposure, anxiety, stress experience, and coping abilities among psychiatrists in private practice compared to physicians in psychiatric and psychosomatic hospitals.E-mail-based questionnaires with 13 items were used to assess anxiety and stress experience. [...]

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2021-11-29
12:43
[DZNE-2021-01583] Journal Article
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Cerebrospinal Fluid Iron-Ferritin Ratio as a Potential Progression Marker for Parkinson's Disease.
Movement disorders 36(12), 2967-2969 () [10.1002/mds.28790]
Longitudinal PD CSF samples were subjected to ICP-MS and the total amount of iron and other bioelements was quantified. Additionally, ferritin and protein biomarkers of neurodegeneration were measured. [...]
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2021-11-29
12:36
[DZNE-2021-01582] Journal Article
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Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
ACS chemical biology 16(11), 2326 - 2338 () [10.1021/acschembio.1c00487]
Leucine-Rich Repeat Kinase 2 (LRRK2) is a large, multidomain protein with dual kinase and GTPase function that is commonly mutated in both familial and idiopathic Parkinson's Disease (PD). While dimerization of LRRK2 is commonly detected in PD models, it remains unclear whether inhibition of dimerization can regulate catalytic activity and pathogenesis. [...]

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2021-11-29
12:33
[DZNE-2021-01581] Journal Article
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Binaural processing deficit and cognitive impairment in Alzheimer's disease.
Alzheimer's and dementia epub, alz.12464 () [10.1002/alz.12464]
Speech comprehension in noisy environments depends on central auditory functions, which are vulnerable in Alzheimer's disease (AD). Binaural processing exploits two ear sounds to optimally process degraded sound information; its characteristics are poorly understood in AD. [...]

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