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000136002 037__ $$aDZNE-2020-02324
000136002 041__ $$aEnglish
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000136002 1001_ $$0P:(DE-HGF)0$$aPuttagunta, Radhika$$b0$$eCorresponding author
000136002 245__ $$aPCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system.
000136002 260__ $$a[London]$$bNature Publishing Group UK$$c2014
000136002 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2014-04-01
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000136002 520__ $$aAxonal regenerative failure is a major cause of neurological impairment following central nervous system (CNS) but not peripheral nervous system (PNS) injury. Notably, PNS injury triggers a coordinated regenerative gene expression programme. However, the molecular link between retrograde signalling and the regulation of this gene expression programme that leads to the differential regenerative capacity remains elusive. Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. Furthermore, we find that extracellular signal-regulated kinase (ERK)-mediated retrograde signalling is required for PCAF-dependent regenerative gene reprogramming. Finally, PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury. Thus, we find a specific epigenetic mechanism that regulates axonal regeneration of CNS axons, suggesting novel targets for clinical application.
000136002 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000136002 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x1
000136002 542__ $$2Crossref$$i2014-04-01$$uhttp://www.springer.com/tdm
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000136002 650_7 $$2NLM Chemicals$$aHistones
000136002 650_7 $$0EC 2.3.1.48$$2NLM Chemicals$$ap300-CBP Transcription Factors
000136002 650_7 $$0EC 2.3.1.48$$2NLM Chemicals$$ap300-CBP-associated factor
000136002 650_2 $$2MeSH$$aAcetylation
000136002 650_2 $$2MeSH$$aAnimals
000136002 650_2 $$2MeSH$$aAxons: enzymology
000136002 650_2 $$2MeSH$$aCentral Nervous System: physiology
000136002 650_2 $$2MeSH$$aEpigenesis, Genetic
000136002 650_2 $$2MeSH$$aFemale
000136002 650_2 $$2MeSH$$aHistones: metabolism
000136002 650_2 $$2MeSH$$aHumans
000136002 650_2 $$2MeSH$$aMale
000136002 650_2 $$2MeSH$$aMice
000136002 650_2 $$2MeSH$$aMice, Knockout: genetics
000136002 650_2 $$2MeSH$$aNerve Regeneration
000136002 650_2 $$2MeSH$$aSpinal Cord Injuries: enzymology
000136002 650_2 $$2MeSH$$aSpinal Cord Injuries: genetics
000136002 650_2 $$2MeSH$$aSpinal Cord Injuries: physiopathology
000136002 650_2 $$2MeSH$$ap300-CBP Transcription Factors: genetics
000136002 650_2 $$2MeSH$$ap300-CBP Transcription Factors: metabolism
000136002 7001_ $$0P:(DE-2719)2810470$$aTedeschi, Andrea$$b1$$udzne
000136002 7001_ $$aSória, Marilia Grando$$b2
000136002 7001_ $$aHervera, Arnau$$b3
000136002 7001_ $$aLindner, Ricco$$b4
000136002 7001_ $$aRathore, Khizr I$$b5
000136002 7001_ $$aGaub, Perrine$$b6
000136002 7001_ $$0P:(DE-2719)2630369$$aJoshi, Yashashree$$b7$$udzne
000136002 7001_ $$aNguyen, Tuan$$b8
000136002 7001_ $$0P:(DE-HGF)0$$aSchmandke, Antonio$$b9
000136002 7001_ $$0P:(DE-2719)2810278$$aLaskowski, Claudia J$$b10$$udzne
000136002 7001_ $$aBoutillier, Anne-Laurence$$b11
000136002 7001_ $$0P:(DE-2719)2810270$$aBradke, Frank$$b12$$udzne
000136002 7001_ $$aDi Giovanni, Simone$$b13
000136002 77318 $$2Crossref$$3journal-article$$a10.1038/ncomms4527$$b : Springer Science and Business Media LLC, 2014-04-01$$n1$$p3527$$tNature Communications$$v5$$x2041-1723$$y2014
000136002 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/ncomms4527$$gVol. 5, no. 1, p. 3527$$n1$$p3527$$q5:1<3527$$tNature Communications$$v5$$x2041-1723$$y2014
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