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@ARTICLE{Puttagunta:136002,
      author       = {Puttagunta, Radhika and Tedeschi, Andrea and Sória,
                      Marilia Grando and Hervera, Arnau and Lindner, Ricco and
                      Rathore, Khizr I and Gaub, Perrine and Joshi, Yashashree and
                      Nguyen, Tuan and Schmandke, Antonio and Laskowski, Claudia J
                      and Boutillier, Anne-Laurence and Bradke, Frank and Di
                      Giovanni, Simone},
      title        = {{PCAF}-dependent epigenetic changes promote axonal
                      regeneration in the central nervous system.},
      journal      = {Nature Communications},
      volume       = {5},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2020-02324},
      pages        = {3527},
      year         = {2014},
      abstract     = {Axonal regenerative failure is a major cause of
                      neurological impairment following central nervous system
                      (CNS) but not peripheral nervous system (PNS) injury.
                      Notably, PNS injury triggers a coordinated regenerative gene
                      expression programme. However, the molecular link between
                      retrograde signalling and the regulation of this gene
                      expression programme that leads to the differential
                      regenerative capacity remains elusive. Here we show through
                      systematic epigenetic studies that the histone
                      acetyltransferase p300/CBP-associated factor (PCAF) promotes
                      acetylation of histone 3 Lys 9 at the promoters of
                      established key regeneration-associated genes following a
                      peripheral but not a central axonal injury. Furthermore, we
                      find that extracellular signal-regulated kinase
                      (ERK)-mediated retrograde signalling is required for
                      PCAF-dependent regenerative gene reprogramming. Finally,
                      PCAF is necessary for conditioning-dependent axonal
                      regeneration and also singularly promotes regeneration after
                      spinal cord injury. Thus, we find a specific epigenetic
                      mechanism that regulates axonal regeneration of CNS axons,
                      suggesting novel targets for clinical application.},
      keywords     = {Acetylation / Animals / Axons: enzymology / Central Nervous
                      System: physiology / Epigenesis, Genetic / Female /
                      Histones: metabolism / Humans / Male / Mice / Mice,
                      Knockout: genetics / Nerve Regeneration / Spinal Cord
                      Injuries: enzymology / Spinal Cord Injuries: genetics /
                      Spinal Cord Injuries: physiopathology / p300-CBP
                      Transcription Factors: genetics / p300-CBP Transcription
                      Factors: metabolism / Histones (NLM Chemicals) / p300-CBP
                      Transcription Factors (NLM Chemicals) / p300-CBP-associated
                      factor (NLM Chemicals)},
      cin          = {AG Bradke / AG N.N. 3},
      ddc          = {500},
      cid          = {I:(DE-2719)1013002 / I:(DE-2719)1240015},
      pnm          = {341 - Molecular Signaling (POF3-341) / 344 - Clinical and
                      Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-341 / G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24686445},
      doi          = {10.1038/ncomms4527},
      url          = {https://pub.dzne.de/record/136002},
}