guest ::
| Home > Publications Database > PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system. > print |
| Home > Publications Database > PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system. > print |
| 001 | 136002 | ||
| 005 | 20240423153211.0 | ||
| 024 | 7 | _ | |a 10.1038/ncomms4527 |2 doi |
| 024 | 7 | _ | |a pmid:24686445 |2 pmid |
| 024 | 7 | _ | |a altmetric:2229071 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-02324 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Puttagunta, Radhika |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system. |
| 260 | _ | _ | |a [London] |c 2014 |b Nature Publishing Group UK |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2014-04-01 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2014-05-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1713879083_10934 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Axonal regenerative failure is a major cause of neurological impairment following central nervous system (CNS) but not peripheral nervous system (PNS) injury. Notably, PNS injury triggers a coordinated regenerative gene expression programme. However, the molecular link between retrograde signalling and the regulation of this gene expression programme that leads to the differential regenerative capacity remains elusive. Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. Furthermore, we find that extracellular signal-regulated kinase (ERK)-mediated retrograde signalling is required for PCAF-dependent regenerative gene reprogramming. Finally, PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury. Thus, we find a specific epigenetic mechanism that regulates axonal regeneration of CNS axons, suggesting novel targets for clinical application. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 1 |
| 542 | _ | _ | |i 2014-04-01 |2 Crossref |u http://www.springer.com/tdm |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Histones |2 NLM Chemicals |
| 650 | _ | 7 | |a p300-CBP Transcription Factors |0 EC 2.3.1.48 |2 NLM Chemicals |
| 650 | _ | 7 | |a p300-CBP-associated factor |0 EC 2.3.1.48 |2 NLM Chemicals |
| 650 | _ | 2 | |a Acetylation |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Axons: enzymology |2 MeSH |
| 650 | _ | 2 | |a Central Nervous System: physiology |2 MeSH |
| 650 | _ | 2 | |a Epigenesis, Genetic |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Histones: metabolism |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Knockout: genetics |2 MeSH |
| 650 | _ | 2 | |a Nerve Regeneration |2 MeSH |
| 650 | _ | 2 | |a Spinal Cord Injuries: enzymology |2 MeSH |
| 650 | _ | 2 | |a Spinal Cord Injuries: genetics |2 MeSH |
| 650 | _ | 2 | |a Spinal Cord Injuries: physiopathology |2 MeSH |
| 650 | _ | 2 | |a p300-CBP Transcription Factors: genetics |2 MeSH |
| 650 | _ | 2 | |a p300-CBP Transcription Factors: metabolism |2 MeSH |
| 700 | 1 | _ | |a Tedeschi, Andrea |0 P:(DE-2719)2810470 |b 1 |u dzne |
| 700 | 1 | _ | |a Sória, Marilia Grando |b 2 |
| 700 | 1 | _ | |a Hervera, Arnau |b 3 |
| 700 | 1 | _ | |a Lindner, Ricco |b 4 |
| 700 | 1 | _ | |a Rathore, Khizr I |b 5 |
| 700 | 1 | _ | |a Gaub, Perrine |b 6 |
| 700 | 1 | _ | |a Joshi, Yashashree |0 P:(DE-2719)2630369 |b 7 |u dzne |
| 700 | 1 | _ | |a Nguyen, Tuan |b 8 |
| 700 | 1 | _ | |a Schmandke, Antonio |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Laskowski, Claudia J |0 P:(DE-2719)2810278 |b 10 |u dzne |
| 700 | 1 | _ | |a Boutillier, Anne-Laurence |b 11 |
| 700 | 1 | _ | |a Bradke, Frank |0 P:(DE-2719)2810270 |b 12 |u dzne |
| 700 | 1 | _ | |a Di Giovanni, Simone |b 13 |
| 773 | 1 | 8 | |a 10.1038/ncomms4527 |b : Springer Science and Business Media LLC, 2014-04-01 |n 1 |p 3527 |3 journal-article |2 Crossref |t Nature Communications |v 5 |y 2014 |x 2041-1723 |
| 773 | _ | _ | |a 10.1038/ncomms4527 |g Vol. 5, no. 1, p. 3527 |0 PERI:(DE-600)2553671-0 |n 1 |q 5:1<3527 |p 3527 |t Nature Communications |v 5 |y 2014 |x 2041-1723 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/136002/files/DZNE-2020-02324_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/136002/files/DZNE-2020-02324_Restricted.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:136002 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)2810470 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 7 |6 P:(DE-2719)2630369 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 10 |6 P:(DE-2719)2810278 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 12 |6 P:(DE-2719)2810270 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-341 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Molecular Signaling |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-344 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 1 |
| 914 | 1 | _ | |y 2014 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NAT COMMUN : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Blind peer review |
| 915 | _ | _ | |a Creative Commons Attribution CC BY (No Version) |0 LIC:(DE-HGF)CCBYNV |2 V:(DE-HGF) |b DOAJ |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b NAT COMMUN : 2017 |
| 920 | 1 | _ | |0 I:(DE-2719)1013002 |k AG Bradke |l Axon Growth and Regeneration |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1240015 |k AG N.N. 3 |l AG N.N. |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1013002 |
| 980 | _ | _ | |a I:(DE-2719)1240015 |
| 980 | _ | _ | |a UNRESTRICTED |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev.ne.12.030189.001015 |2 Crossref |o 10.1146/annurev.ne.12.030189.001015 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1186/1471-2202-4-8 |2 Crossref |o 10.1186/1471-2202-4-8 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1460-9568.2007.05597.x |2 Crossref |o 10.1111/j.1460-9568.2007.05597.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/cne.21944 |2 Crossref |o 10.1002/cne.21944 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1471-4159.2006.04089.x |2 Crossref |o 10.1111/j.1471-4159.2006.04089.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.expneurol.2009.08.010 |2 Crossref |o 10.1016/j.expneurol.2009.08.010 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0896-6273(00)80755-2 |2 Crossref |o 10.1016/S0896-6273(00)80755-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/sj.npp.1301551 |2 Crossref |o 10.1038/sj.npp.1301551 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.0589-04.2004 |2 Crossref |o 10.1523/JNEUROSCI.0589-04.2004 |
| 999 | C | 5 | |y 2010 |2 Crossref |o IA Qureshi 2010 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1076469 |2 Crossref |o 10.1126/science.1076469 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/0092-8674(87)90616-7 |2 Crossref |o 10.1016/0092-8674(87)90616-7 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/0196-9781(85)90118-4 |2 Crossref |o 10.1016/0196-9781(85)90118-4 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.08-07-02394.1988 |2 Crossref |o 10.1523/JNEUROSCI.08-07-02394.1988 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.expneurol.2009.07.022 |2 Crossref |o 10.1016/j.expneurol.2009.07.022 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1172/JCI40000 |2 Crossref |o 10.1172/JCI40000 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ng.154 |2 Crossref |o 10.1038/ng.154 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev-neuro-061010-113723 |2 Crossref |o 10.1146/annurev-neuro-061010-113723 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.5313-06.2007 |2 Crossref |o 10.1523/JNEUROSCI.5313-06.2007 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.mcn.2004.01.007 |2 Crossref |o 10.1016/j.mcn.2004.01.007 |
| 999 | C | 5 | |y 1986 |2 Crossref |o JP Julien 1986 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1177/1073858404267884 |2 Crossref |o 10.1177/1073858404267884 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2005.01.023 |2 Crossref |o 10.1016/j.neuron.2005.01.023 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1006/mcne.2001.1015 |2 Crossref |o 10.1006/mcne.2001.1015 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.270.46.27489 |2 Crossref |o 10.1074/jbc.270.46.27489 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M408174200 |2 Crossref |o 10.1074/jbc.M408174200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.expneurol.2011.12.037 |2 Crossref |o 10.1016/j.expneurol.2011.12.037 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0896-6273(02)00730-4 |2 Crossref |o 10.1016/S0896-6273(02)00730-4 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M402839200 |2 Crossref |o 10.1074/jbc.M402839200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cub.2009.04.017 |2 Crossref |o 10.1016/j.cub.2009.04.017 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2013.10.004 |2 Crossref |o 10.1016/j.cell.2013.10.004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.0589-13.2013 |2 Crossref |o 10.1523/JNEUROSCI.0589-13.2013 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/brain/awr142 |2 Crossref |o 10.1093/brain/awr142 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/sj.emboj.7601292 |2 Crossref |o 10.1038/sj.emboj.7601292 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/cdd.2008.175 |2 Crossref |o 10.1038/cdd.2008.175 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/cdd.2009.216 |2 Crossref |o 10.1038/cdd.2009.216 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0896-6273(03)00770-0 |2 Crossref |o 10.1016/S0896-6273(03)00770-0 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2008.05.029 |2 Crossref |o 10.1016/j.neuron.2008.05.029 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2012.04.028 |2 Crossref |o 10.1016/j.neuron.2012.04.028 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.1925-12.2012 |2 Crossref |o 10.1523/JNEUROSCI.1925-12.2012 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ng1598 |2 Crossref |o 10.1038/ng1598 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/gr.074609.107 |2 Crossref |o 10.1101/gr.074609.107 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.4416-09.2009 |2 Crossref |o 10.1523/JNEUROSCI.4416-09.2009 |
| 999 | C | 5 | |y 2011 |2 Crossref |o E Floriddia 2011 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1083/jcb.201102066 |2 Crossref |o 10.1083/jcb.201102066 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M109.015719 |2 Crossref |o 10.1074/jbc.M109.015719 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/0014-2999(80)90515-4 |2 Crossref |o 10.1016/0014-2999(80)90515-4 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1161566 |2 Crossref |o 10.1126/science.1161566 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nn.2603 |2 Crossref |o 10.1038/nn.2603 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1100426108 |2 Crossref |o 10.1073/pnas.1100426108 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/cne.10593 |2 Crossref |o 10.1002/cne.10593 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|