001     136065
005     20240321220016.0
024 7 _ |a 10.1002/bip.21380
|2 doi
024 7 _ |a pmid:20593476
|2 pmid
024 7 _ |a 0006-3525
|2 ISSN
024 7 _ |a 1097-0282
|2 ISSN
037 _ _ |a DZNE-2020-02387
041 _ _ |a English
082 _ _ |a 540
100 1 _ |a Schumacher, Miria C
|0 P:(DE-HGF)0
|b 0
245 _ _ |a Synthesis of a GPI anchor module suitable for protein post-translational modification.
260 _ _ |a New York, NY
|c 2010
|b Wiley76466
264 _ 1 |3 online
|2 Crossref
|b Wiley
|c 2010-06-30
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
|b journal
|m journal
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Eukaryotic cell surface proteins are often modified by a glycosylphosphatidylinositol (GPI) anchor. More than 200 of these post-translationally altered proteins are presently known, a prominent example being the prion protein (PrP). Although the significance of the GPI anchor is well recognized, efforts to study its function are hampered due to its complex chemical nature, which combines hydrophilic glycosyl chains with hydrophobic lipid moieties. Here we describe a general method for the synthesis of a GPI-anchored peptide containing an N-terminal Cys. This module can be employed for the production of proteins containing a natural GPI anchor using expressed protein ligation.
536 _ _ |a 341 - Molecular Signaling (POF3-341)
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|c POF3-341
|f POF III
|x 0
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
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|c POF3-342
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542 _ _ |i 2015-09-01
|2 Crossref
|u http://doi.wiley.com/10.1002/tdm_license_1.1
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Glycosylphosphatidylinositols
|2 NLM Chemicals
650 _ 7 |a Peptides
|2 NLM Chemicals
650 _ 7 |a Prions
|2 NLM Chemicals
650 _ 2 |a Glycosylphosphatidylinositols: chemical synthesis
|2 MeSH
650 _ 2 |a Glycosylphosphatidylinositols: chemistry
|2 MeSH
650 _ 2 |a Glycosylphosphatidylinositols: genetics
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Peptides: chemical synthesis
|2 MeSH
650 _ 2 |a Peptides: chemistry
|2 MeSH
650 _ 2 |a Peptides: genetics
|2 MeSH
650 _ 2 |a Prions: biosynthesis
|2 MeSH
650 _ 2 |a Prions: chemical synthesis
|2 MeSH
650 _ 2 |a Prions: chemistry
|2 MeSH
650 _ 2 |a Prions: genetics
|2 MeSH
650 _ 2 |a Protein Processing, Post-Translational
|2 MeSH
650 _ 2 |a Saccharomyces cerevisiae: genetics
|2 MeSH
650 _ 2 |a Saccharomyces cerevisiae: metabolism
|2 MeSH
700 1 _ |a Resenberger, Ulrike
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|b 1
|u dzne
700 1 _ |a Seidel, Ralf P
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700 1 _ |a Becker, Christian F W
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700 1 _ |a Winklhofer, Konstanze F
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700 1 _ |a Oesterhelt, Dieter
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700 1 _ |a Tatzelt, Jörg
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700 1 _ |a Engelhard, Martin
|0 P:(DE-HGF)0
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|e Corresponding author
773 1 8 |a 10.1002/bip.21380
|b : Wiley, 2010-06-30
|n 4
|p 457-464
|3 journal-article
|2 Crossref
|t Biopolymers
|v 94
|y 2010
|x 0006-3525
773 _ _ |a 10.1002/bip.21380
|g Vol. 94, no. 4, p. 457 - 464
|0 PERI:(DE-600)1480801-8
|n 4
|q 94:4<457 - 464
|p 457-464
|t Biopolymers
|v 94
|y 2010
|x 0006-3525
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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914 1 _ |y 2010
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LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21