000136084 001__ 136084
000136084 005__ 20240321220017.0
000136084 0247_ $$2doi$$a10.1101/gr.105106.110
000136084 0247_ $$2pmid$$apmid:20548051
000136084 0247_ $$2pmc$$apmc:PMC2909578
000136084 0247_ $$2ISSN$$a1054-9803
000136084 0247_ $$2ISSN$$a1088-9051
000136084 0247_ $$2ISSN$$a1549-5469
000136084 0247_ $$2altmetric$$aaltmetric:222181
000136084 037__ $$aDZNE-2020-02406
000136084 041__ $$aEnglish
000136084 082__ $$a540
000136084 1001_ $$0P:(DE-HGF)0$$aCox, Brian J$$b0
000136084 245__ $$aPhenotypic annotation of the mouse X chromosome.
000136084 260__ $$aCold Spring Harbor, NY$$bLaboratory Press$$c2010
000136084 264_1 $$2Crossref$$3online$$bCold Spring Harbor Laboratory$$c2010-06-14
000136084 264_1 $$2Crossref$$3print$$bCold Spring Harbor Laboratory$$c2010-08-01
000136084 3367_ $$2DRIVER$$aarticle
000136084 3367_ $$2DataCite$$aOutput Types/Journal article
000136084 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1584962344_14677
000136084 3367_ $$2BibTeX$$aARTICLE
000136084 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000136084 3367_ $$00$$2EndNote$$aJournal Article
000136084 520__ $$aMutational screens are an effective means used in the functional annotation of a genome. We present a method for a mutational screen of the mouse X chromosome using gene trap technologies. This method has the potential to screen all of the genes on the X chromosome without establishing mutant animals, as all gene-trapped embryonic stem (ES) cell lines are hemizygous null for mutations on the X chromosome. Based on this method, embryonic morphological phenotypes and expression patterns for 58 genes were assessed, approximately 10% of all human and mouse syntenic genes on the X chromosome. Of these, 17 are novel embryonic lethal mutations and nine are mutant mouse models of genes associated with genetic disease in humans, including BCOR and PORCN. The rate of lethal mutations is similar to previous mutagenic screens of the autosomes. Interestingly, some genes associated with X-linked mental retardation (XLMR) in humans show lethal phenotypes in mice, suggesting that null mutations cannot be responsible for all cases of XLMR. The entire data set is available via the publicly accessible website (http://xlinkedgenes.ibme.utoronto.ca/).
000136084 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000136084 588__ $$aDataset connected to CrossRef, PubMed,
000136084 650_7 $$2NLM Chemicals$$aBCOR protein, human
000136084 650_7 $$2NLM Chemicals$$aMembrane Proteins
000136084 650_7 $$2NLM Chemicals$$aProto-Oncogene Proteins
000136084 650_7 $$2NLM Chemicals$$aRepressor Proteins
000136084 650_7 $$0EC 2.3.-$$2NLM Chemicals$$aAcyltransferases
000136084 650_7 $$0EC 2.3.1.-$$2NLM Chemicals$$aPORCN protein, human
000136084 650_2 $$2MeSH$$aAcyltransferases
000136084 650_2 $$2MeSH$$aAnimals
000136084 650_2 $$2MeSH$$aBase Sequence
000136084 650_2 $$2MeSH$$aChromosomes, Human, X: genetics
000136084 650_2 $$2MeSH$$aDNA Mutational Analysis: methods
000136084 650_2 $$2MeSH$$aGenes, Lethal
000136084 650_2 $$2MeSH$$aGenes, X-Linked
000136084 650_2 $$2MeSH$$aGenetic Diseases, X-Linked: genetics
000136084 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000136084 650_2 $$2MeSH$$aGenetic Testing: methods
000136084 650_2 $$2MeSH$$aHumans
000136084 650_2 $$2MeSH$$aMembrane Proteins: genetics
000136084 650_2 $$2MeSH$$aMental Retardation, X-Linked: genetics
000136084 650_2 $$2MeSH$$aMice
000136084 650_2 $$2MeSH$$aMolecular Sequence Annotation
000136084 650_2 $$2MeSH$$aMolecular Sequence Data
000136084 650_2 $$2MeSH$$aPhenotype
000136084 650_2 $$2MeSH$$aProto-Oncogene Proteins: genetics
000136084 650_2 $$2MeSH$$aRepressor Proteins: genetics
000136084 650_2 $$2MeSH$$aX Chromosome: genetics
000136084 7001_ $$0P:(DE-HGF)0$$aVollmer, Marion$$b1
000136084 7001_ $$0P:(DE-HGF)0$$aTamplin, Owen$$b2
000136084 7001_ $$0P:(DE-HGF)0$$aLu, Mei$$b3
000136084 7001_ $$0P:(DE-HGF)0$$aBiechele, Steffen$$b4
000136084 7001_ $$0P:(DE-HGF)0$$aGertsenstein, Marina$$b5
000136084 7001_ $$0P:(DE-HGF)0$$avan Campenhout, Claude$$b6
000136084 7001_ $$0P:(DE-HGF)0$$aFloss, Thomas$$b7
000136084 7001_ $$0P:(DE-HGF)0$$aKühn, Ralf$$b8
000136084 7001_ $$0P:(DE-2719)2000028$$aWurst, Wolfgang$$b9$$udzne
000136084 7001_ $$0P:(DE-HGF)0$$aLickert, Heiko$$b10$$eCorresponding author
000136084 7001_ $$0P:(DE-HGF)0$$aRossant, Janet$$b11
000136084 77318 $$2Crossref$$3journal-article$$a10.1101/gr.105106.110$$b : Cold Spring Harbor Laboratory, 2010-06-14$$n8$$p1154-1164$$tGenome Research$$v20$$x1088-9051$$y2010
000136084 773__ $$0PERI:(DE-600)1483456-X$$a10.1101/gr.105106.110$$gVol. 20, no. 8, p. 1154 - 1164$$n8$$p1154-1164$$q20:8<1154 - 1164$$tGenome research$$v20$$x1088-9051$$y2010
000136084 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909578
000136084 909CO $$ooai:pub.dzne.de:136084$$pVDB
000136084 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000028$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000136084 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000136084 9141_ $$y2010
000136084 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000136084 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000136084 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000136084 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000136084 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000136084 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000136084 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000136084 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000136084 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000136084 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000136084 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000136084 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000136084 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bGENOME RES : 2017
000136084 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bGENOME RES : 2017
000136084 9201_ $$0I:(DE-2719)1140001$$kAG Wurst$$lGenome Engineering$$x0
000136084 980__ $$ajournal
000136084 980__ $$aVDB
000136084 980__ $$aI:(DE-2719)1140001
000136084 980__ $$aUNRESTRICTED