TY  - JOUR
AU  - Cox, Brian J
AU  - Vollmer, Marion
AU  - Tamplin, Owen
AU  - Lu, Mei
AU  - Biechele, Steffen
AU  - Gertsenstein, Marina
AU  - van Campenhout, Claude
AU  - Floss, Thomas
AU  - Kühn, Ralf
AU  - Wurst, Wolfgang
AU  - Lickert, Heiko
AU  - Rossant, Janet
TI  - Phenotypic annotation of the mouse X chromosome.
JO  - Genome research
VL  - 20
IS  - 8
SN  - 1088-9051
CY  - Cold Spring Harbor, NY
PB  - Laboratory Press
M1  - DZNE-2020-02406
SP  - 1154-1164
PY  - 2010
AB  - Mutational screens are an effective means used in the functional annotation of a genome. We present a method for a mutational screen of the mouse X chromosome using gene trap technologies. This method has the potential to screen all of the genes on the X chromosome without establishing mutant animals, as all gene-trapped embryonic stem (ES) cell lines are hemizygous null for mutations on the X chromosome. Based on this method, embryonic morphological phenotypes and expression patterns for 58 genes were assessed, approximately 10
KW  - Acyltransferases
KW  - Animals
KW  - Base Sequence
KW  - Chromosomes, Human, X: genetics
KW  - DNA Mutational Analysis: methods
KW  - Genes, Lethal
KW  - Genes, X-Linked
KW  - Genetic Diseases, X-Linked: genetics
KW  - Genetic Predisposition to Disease
KW  - Genetic Testing: methods
KW  - Humans
KW  - Membrane Proteins: genetics
KW  - Mental Retardation, X-Linked: genetics
KW  - Mice
KW  - Molecular Sequence Annotation
KW  - Molecular Sequence Data
KW  - Phenotype
KW  - Proto-Oncogene Proteins: genetics
KW  - Repressor Proteins: genetics
KW  - X Chromosome: genetics
KW  - BCOR protein, human (NLM Chemicals)
KW  - Membrane Proteins (NLM Chemicals)
KW  - Proto-Oncogene Proteins (NLM Chemicals)
KW  - Repressor Proteins (NLM Chemicals)
KW  - Acyltransferases (NLM Chemicals)
KW  - PORCN protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:20548051
C2  - pmc:PMC2909578
DO  - DOI:10.1101/gr.105106.110
UR  - https://pub.dzne.de/record/136084
ER  -