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| 001 | 136092 | ||
| 005 | 20240321220018.0 | ||
| 024 | 7 | _ | |a 10.1371/journal.pone.0012247 |2 doi |
| 024 | 7 | _ | |a pmid:20806063 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC2923622 |2 pmc |
| 024 | 7 | _ | |a altmetric:35379274 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-02414 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Voigt, Aaron |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a TDP-43-mediated neuron loss in vivo requires RNA-binding activity. |
| 260 | _ | _ | |a San Francisco, California, US |c 2010 |b PLOS |
| 264 | _ | 1 | |3 online |2 Crossref |b Public Library of Science (PLoS) |c 2010-08-18 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1604669674_15308 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Alteration and/or mutations of the ribonucleoprotein TDP-43 have been firmly linked to human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The relative impacts of TDP-43 alteration, mutation, or inherent protein function on neural integrity, however, remain less clear--a situation confounded by conflicting reports based on transient and/or random-insertion transgenic expression. We therefore performed a stringent comparative investigation of impacts of these TDP-43 modifications on neural integrity in vivo. To achieve this, we systematically screened ALS/FTLD-associated and synthetic TDP-43 isoforms via same-site gene insertion and neural expression in Drosophila; followed by transposon-based motor neuron-specific transgenesis in a chick vertebrate system. Using this bi-systemic approach we uncovered a requirement of inherent TDP-43 RNA-binding function--but not ALS/FTLD-linked mutation, mislocalization, or truncation--for TDP-43-mediated neurotoxicity in vivo. |
| 536 | _ | _ | |a 345 - Population Studies and Genetics (POF3-345) |0 G:(DE-HGF)POF3-345 |c POF3-345 |f POF III |x 0 |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 1 |
| 542 | _ | _ | |i 2010-08-18 |2 Crossref |u http://creativecommons.org/licenses/by/4.0/ |
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| 650 | _ | 7 | |a DNA-Binding Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a RNA |0 63231-63-0 |2 NLM Chemicals |
| 650 | _ | 2 | |a Amyotrophic Lateral Sclerosis: genetics |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Cell Line |2 MeSH |
| 650 | _ | 2 | |a Chickens: genetics |2 MeSH |
| 650 | _ | 2 | |a Chickens: metabolism |2 MeSH |
| 650 | _ | 2 | |a Chickens: physiology |2 MeSH |
| 650 | _ | 2 | |a DNA-Binding Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a DNA-Binding Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Drosophila melanogaster: cytology |2 MeSH |
| 650 | _ | 2 | |a Drosophila melanogaster: genetics |2 MeSH |
| 650 | _ | 2 | |a Drosophila melanogaster: metabolism |2 MeSH |
| 650 | _ | 2 | |a Drosophila melanogaster: physiology |2 MeSH |
| 650 | _ | 2 | |a Frontotemporal Lobar Degeneration: genetics |2 MeSH |
| 650 | _ | 2 | |a Gene Expression Regulation |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Intracellular Space: metabolism |2 MeSH |
| 650 | _ | 2 | |a Locomotion |2 MeSH |
| 650 | _ | 2 | |a Longevity |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Motor Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Mutation |2 MeSH |
| 650 | _ | 2 | |a Neurons: cytology |2 MeSH |
| 650 | _ | 2 | |a Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Organ Specificity |2 MeSH |
| 650 | _ | 2 | |a Protein Binding |2 MeSH |
| 650 | _ | 2 | |a Protein Transport |2 MeSH |
| 650 | _ | 2 | |a RNA: metabolism |2 MeSH |
| 700 | 1 | _ | |a Herholz, David |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Fiesel, Fabienne C |0 P:(DE-2719)9000399 |b 2 |u dzne |
| 700 | 1 | _ | |a Kaur, Kavita |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Müller, Daniel |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Karsten, Peter |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Weber, Stephanie S |0 P:(DE-2719)2662310 |b 6 |
| 700 | 1 | _ | |a Kahle, Phillip |0 P:(DE-2719)2810803 |b 7 |
| 700 | 1 | _ | |a Marquardt, Till |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Schulz, Jörg B |0 P:(DE-HGF)0 |b 9 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1371/journal.pone.0012247 |b : Public Library of Science (PLoS), 2010-08-18 |n 8 |p e12247 |3 journal-article |2 Crossref |t PLoS ONE |v 5 |y 2010 |x 1932-6203 |
| 773 | _ | _ | |a 10.1371/journal.pone.0012247 |g Vol. 5, no. 8, p. e12247 - |0 PERI:(DE-600)2267670-3 |n 8 |q 5:8 |t PLOS ONE |v 5 |y 2010 |x 1932-6203 |
| 856 | 4 | _ | |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012247 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923622 |
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