TY  - JOUR
AU  - Minnerop, Martina
AU  - Lüders, Eileen
AU  - Specht, Karsten
AU  - Ruhlmann, Jürgen
AU  - Schimke, Nicole
AU  - Thompson, Paul M
AU  - Chou, Yi Y
AU  - Toga, Arthur W
AU  - Abele, Michael
AU  - Wüllner, Ullrich
AU  - Klockgether, Thomas
TI  - Callosal tissue loss in multiple system atrophy-a one-year follow-up study.
JO  - Movement disorders
VL  - 25
IS  - 15
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2020-02456
SP  - 2613-2620
PY  - 2010
AB  - Multiple system atrophy (MSA) is a neurodegenerative disease not only affecting the basal ganglia, brainstem, cerebellum, and intermediolateral cell columns of the spinal cord but also the cerebral cortex. Clinically, cerebellar (MSA-C) and parkinsonian variants of MSA (MSA-P) are distinguished. We investigated 14 MSA patients (10 MSA-C, 4 MSA-P, men: 7, women: 7; age: 61.1 ± 3.3 years) and 14 matched controls (men: 7, women: 7; age: 58.6 ± 5.1 years) with voxel-based morphometry (VBM) to analyze gray and white matter differences both at baseline and at follow-up, 1 year later. Baseline comparisons between patients and controls confirmed significantly less gray matter in MSA in the cerebellum and cerebral cortex, and significantly less white matter in the cerebellar peduncles and brainstem. Comparisons of tissue-loss profiles (i.e., baseline versus follow-up) between patients and controls, revealed white matter reduction in MSA along the middle cerebellar peduncles, reflecting degeneration of the ponto-cerebellar tract as a particularly prominent and progressive morphological alteration in MSA. Comparisons between baseline and follow-up, separately performed in patients and controls, revealed additional white matter reduction in MSA along the corpus callosum at follow-up. This was replicated through additional shape-based analyses indicating a reduced callosal thickness in the anterior and posterior midbody, extending posteriorly into the isthmus. Callosal atrophy may possibly reflect a disease-specific pattern of neurodegeneration and cortical atrophy, fitting well with the predominant impairment of motor functions in the MSA patients.
KW  - Aged
KW  - Atrophy: pathology
KW  - Brain Stem: pathology
KW  - Cerebellum: pathology
KW  - Corpus Callosum: pathology
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Image Processing, Computer-Assisted
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Multiple System Atrophy: pathology
LB  - PUB:(DE-HGF)16
C6  - pmid:20623690
C2  - pmc:PMC2989455
DO  - DOI:10.1002/mds.23318
UR  - https://pub.dzne.de/record/136134
ER  -