% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Minnerop:136134,
      author       = {Minnerop, Martina and Lüders, Eileen and Specht, Karsten
                      and Ruhlmann, Jürgen and Schimke, Nicole and Thompson, Paul
                      M and Chou, Yi Y and Toga, Arthur W and Abele, Michael and
                      Wüllner, Ullrich and Klockgether, Thomas},
      title        = {{C}allosal tissue loss in multiple system atrophy--a
                      one-year follow-up study.},
      journal      = {Movement disorders},
      volume       = {25},
      number       = {15},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2020-02456},
      pages        = {2613-2620},
      year         = {2010},
      abstract     = {Multiple system atrophy (MSA) is a neurodegenerative
                      disease not only affecting the basal ganglia, brainstem,
                      cerebellum, and intermediolateral cell columns of the spinal
                      cord but also the cerebral cortex. Clinically, cerebellar
                      (MSA-C) and parkinsonian variants of MSA (MSA-P) are
                      distinguished. We investigated 14 MSA patients (10 MSA-C, 4
                      MSA-P, men: 7, women: 7; age: 61.1 ± 3.3 years) and 14
                      matched controls (men: 7, women: 7; age: 58.6 ± 5.1 years)
                      with voxel-based morphometry (VBM) to analyze gray and white
                      matter differences both at baseline and at follow-up, 1 year
                      later. Baseline comparisons between patients and controls
                      confirmed significantly less gray matter in MSA in the
                      cerebellum and cerebral cortex, and significantly less white
                      matter in the cerebellar peduncles and brainstem.
                      Comparisons of tissue-loss profiles (i.e., baseline versus
                      follow-up) between patients and controls, revealed white
                      matter reduction in MSA along the middle cerebellar
                      peduncles, reflecting degeneration of the ponto-cerebellar
                      tract as a particularly prominent and progressive
                      morphological alteration in MSA. Comparisons between
                      baseline and follow-up, separately performed in patients and
                      controls, revealed additional white matter reduction in MSA
                      along the corpus callosum at follow-up. This was replicated
                      through additional shape-based analyses indicating a reduced
                      callosal thickness in the anterior and posterior midbody,
                      extending posteriorly into the isthmus. Callosal atrophy may
                      possibly reflect a disease-specific pattern of
                      neurodegeneration and cortical atrophy, fitting well with
                      the predominant impairment of motor functions in the MSA
                      patients.},
      keywords     = {Aged / Atrophy: pathology / Brain Stem: pathology /
                      Cerebellum: pathology / Corpus Callosum: pathology / Female
                      / Follow-Up Studies / Humans / Image Processing,
                      Computer-Assisted / Magnetic Resonance Imaging / Male /
                      Middle Aged / Multiple System Atrophy: pathology},
      cin          = {Pre 2020 / Patient Studies (Bonn)},
      ddc          = {610},
      cid          = {I:(DE-2719)999999 / I:(DE-2719)1011101},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20623690},
      pmc          = {pmc:PMC2989455},
      doi          = {10.1002/mds.23318},
      url          = {https://pub.dzne.de/record/136134},
}