%0 Journal Article
%A Roder, Constantin
%A Peters, Vera
%A Kasuya, Hidetoshi
%A Nishizawa, Tsutomu
%A Takehara, Yayoi
%A Berg, Daniela
%A Schulte, Claudia
%A Khan, Nadia
%A Tatagiba, Marcos
%A Krischek, Boris
%T Common genetic polymorphisms in moyamoya and atherosclerotic disease in Europeans.
%J Zeitschrift für Urheber- und Medienrecht / Rechtsprechungsdienst
%V 27
%N 2
%@ 0256-7040
%C München
%I Beck65642
%M DZNE-2020-02486
%P 245-252
%D 2011
%X Moyamoya is the most common cerebrovascular disease in children in Japan. The disease's etiology is still widely unknown. Several publications describe histopathological changes in the walls of affected vessels similar to those seen in atherosclerosis. In this study, we analyzed the DNA of European patients with Moyamoya disease for single nucleotide polymorphisms associated with atherosclerotic changes.We genotyped 17 SNPs in or adjacent to 11 genes (ELN, LIMK1, CDKN2A/B, CXCL12, Pseudogene ENSG00000197218, PSRC1, MTHFD1L, SMAD3, MIA3, PDGF-B, TIMP2) comparing 40 DNA samples of Moyamoya disease patients to 68 healthy controls from central Europe. The mean age of onset of Moyamoya disease (MMD)-related symptoms was 15.4 years of age. Genotyping was performed by sequencing the SNP containing genetic regions with custom-made primers.We found strong association of one SNP (rs599839 [A/G], OR = 2.17, 95
%K Adolescent
%K Adult
%K Atherosclerosis: genetics
%K Europe
%K European Continental Ancestry Group: genetics
%K Female
%K Genetic Predisposition to Disease
%K Genotype
%K Humans
%K Male
%K Moyamoya Disease: genetics
%K Polymorphism, Single Nucleotide
%K Young Adult
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:20694560
%R 10.1007/s00381-010-1241-8
%U https://pub.dzne.de/record/136164