TY  - JOUR
AU  - Roder, Constantin
AU  - Peters, Vera
AU  - Kasuya, Hidetoshi
AU  - Nishizawa, Tsutomu
AU  - Takehara, Yayoi
AU  - Berg, Daniela
AU  - Schulte, Claudia
AU  - Khan, Nadia
AU  - Tatagiba, Marcos
AU  - Krischek, Boris
TI  - Common genetic polymorphisms in moyamoya and atherosclerotic disease in Europeans.
JO  - Zeitschrift für Urheber- und Medienrecht / Rechtsprechungsdienst
VL  - 27
IS  - 2
SN  - 0256-7040
CY  - München
PB  - Beck65642
M1  - DZNE-2020-02486
SP  - 245-252
PY  - 2011
AB  - Moyamoya is the most common cerebrovascular disease in children in Japan. The disease's etiology is still widely unknown. Several publications describe histopathological changes in the walls of affected vessels similar to those seen in atherosclerosis. In this study, we analyzed the DNA of European patients with Moyamoya disease for single nucleotide polymorphisms associated with atherosclerotic changes.We genotyped 17 SNPs in or adjacent to 11 genes (ELN, LIMK1, CDKN2A/B, CXCL12, Pseudogene ENSG00000197218, PSRC1, MTHFD1L, SMAD3, MIA3, PDGF-B, TIMP2) comparing 40 DNA samples of Moyamoya disease patients to 68 healthy controls from central Europe. The mean age of onset of Moyamoya disease (MMD)-related symptoms was 15.4 years of age. Genotyping was performed by sequencing the SNP containing genetic regions with custom-made primers.We found strong association of one SNP (rs599839 [A/G], OR = 2.17, 95
KW  - Adolescent
KW  - Adult
KW  - Atherosclerosis: genetics
KW  - Europe
KW  - European Continental Ancestry Group: genetics
KW  - Female
KW  - Genetic Predisposition to Disease
KW  - Genotype
KW  - Humans
KW  - Male
KW  - Moyamoya Disease: genetics
KW  - Polymorphism, Single Nucleotide
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:20694560
DO  - DOI:10.1007/s00381-010-1241-8
UR  - https://pub.dzne.de/record/136164
ER  -