%0 Journal Article
%A Gizatullina, Zemfira Z
%A Gaynutdinov, Timur M
%A Svoboda, Hanno
%A Jerzembek, Doreen
%A Knabe, Annette
%A Vielhaber, Stefan
%A Malesevic, Miroslav
%A Heinze, Hans-Jochen
%A Fischer, Gunter
%A Striggow, Frank
%A Gellerich, Frank N
%T Effects of cyclosporine A and its immunosuppressive or non-immunosuppressive derivatives [D-Ser]8-CsA and Cs9 on mitochondria from different brain regions.
%J Mitochondrion
%V 11
%N 3
%@ 1567-7249
%C Amsterdam [u.a.]
%I Elsevier Science
%M DZNE-2020-02534
%P 421-429
%D 2011
%X We studied the functional properties of isolated brain mitochondria (BM) prepared from total rat brain (BM(total)) or from cerebral subregions under basal and Ca(2+) overload conditions in order to evaluate the effects of cyclosporine A (CsA) in a regiospecific manner. CsA-induced effects were compared with those of two derivatives-the none-immunosuppressive [O-(NH(2)(CH2)(5)NHC(O)CH(2))-D-Ser](8)-CsA (Cs9) and its congener, the immunosuppressive [D-Ser](8)-CsA. The glutamate/malate-dependent state 3 respiration of mitochondria (state 3(glu/mal)) differed in region-specific manner (cortex > striatum = cerebellum > substantia nigra > hippocampus), but was significantly increased by 1μM CsA (+21±5
%K Animals
%K Brain: drug effects
%K Calcium: metabolism
%K Cell Respiration: drug effects
%K Cyclosporine: metabolism
%K Energy Metabolism: drug effects
%K Enzyme Inhibitors: metabolism
%K Male
%K Mitochondria: drug effects
%K Rats
%K Enzyme Inhibitors (NLM Chemicals)
%K Cyclosporine (NLM Chemicals)
%K Calcium (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:21167961
%R 10.1016/j.mito.2010.12.012
%U https://pub.dzne.de/record/136212