TY  - JOUR
AU  - Gizatullina, Zemfira Z
AU  - Gaynutdinov, Timur M
AU  - Svoboda, Hanno
AU  - Jerzembek, Doreen
AU  - Knabe, Annette
AU  - Vielhaber, Stefan
AU  - Malesevic, Miroslav
AU  - Heinze, Hans-Jochen
AU  - Fischer, Gunter
AU  - Striggow, Frank
AU  - Gellerich, Frank N
TI  - Effects of cyclosporine A and its immunosuppressive or non-immunosuppressive derivatives [D-Ser]8-CsA and Cs9 on mitochondria from different brain regions.
JO  - Mitochondrion
VL  - 11
IS  - 3
SN  - 1567-7249
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2020-02534
SP  - 421-429
PY  - 2011
AB  - We studied the functional properties of isolated brain mitochondria (BM) prepared from total rat brain (BM(total)) or from cerebral subregions under basal and Ca(2+) overload conditions in order to evaluate the effects of cyclosporine A (CsA) in a regiospecific manner. CsA-induced effects were compared with those of two derivatives-the none-immunosuppressive [O-(NH(2)(CH2)(5)NHC(O)CH(2))-D-Ser](8)-CsA (Cs9) and its congener, the immunosuppressive [D-Ser](8)-CsA. The glutamate/malate-dependent state 3 respiration of mitochondria (state 3(glu/mal)) differed in region-specific manner (cortex > striatum = cerebellum > substantia nigra > hippocampus), but was significantly increased by 1μM CsA (+21±5
KW  - Animals
KW  - Brain: drug effects
KW  - Calcium: metabolism
KW  - Cell Respiration: drug effects
KW  - Cyclosporine: metabolism
KW  - Energy Metabolism: drug effects
KW  - Enzyme Inhibitors: metabolism
KW  - Male
KW  - Mitochondria: drug effects
KW  - Rats
KW  - Enzyme Inhibitors (NLM Chemicals)
KW  - Cyclosporine (NLM Chemicals)
KW  - Calcium (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:21167961
DO  - DOI:10.1016/j.mito.2010.12.012
UR  - https://pub.dzne.de/record/136212
ER  -