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@ARTICLE{Gizatullina:136212,
      author       = {Gizatullina, Zemfira Z and Gaynutdinov, Timur M and
                      Svoboda, Hanno and Jerzembek, Doreen and Knabe, Annette and
                      Vielhaber, Stefan and Malesevic, Miroslav and Heinze,
                      Hans-Jochen and Fischer, Gunter and Striggow, Frank and
                      Gellerich, Frank N},
      title        = {{E}ffects of cyclosporine {A} and its immunosuppressive or
                      non-immunosuppressive derivatives [{D}-{S}er]8-{C}s{A} and
                      {C}s9 on mitochondria from different brain regions.},
      journal      = {Mitochondrion},
      volume       = {11},
      number       = {3},
      issn         = {1567-7249},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-02534},
      pages        = {421-429},
      year         = {2011},
      abstract     = {We studied the functional properties of isolated brain
                      mitochondria (BM) prepared from total rat brain (BM(total))
                      or from cerebral subregions under basal and Ca(2+) overload
                      conditions in order to evaluate the effects of cyclosporine
                      A (CsA) in a regiospecific manner. CsA-induced effects were
                      compared with those of two derivatives-the
                      none-immunosuppressive
                      [O-(NH(2)(CH2)(5)NHC(O)CH(2))-D-Ser](8)-CsA (Cs9) and its
                      congener, the immunosuppressive [D-Ser](8)-CsA. The
                      glutamate/malate-dependent state 3 respiration of
                      mitochondria (state 3(glu/mal)) differed in region-specific
                      manner (cortex > striatum = cerebellum > substantia nigra >
                      hippocampus), but was significantly increased by 1μM CsA
                      $(+21±5\%)$ in all regions. Ca(2+) overload induced by
                      addition of 20μM Ca(2+) caused a significant decrease of
                      state 3(glu/mal) (-45 to $-55\%)$ which was almost
                      completely prevented in the presence of 1μM CsA, 1μM Cs9
                      or 1μM [D-Ser](8)-CsA. Mitochondrial Ca(2+) accumulation
                      thresholds linked to permeability transition (PT) as well as
                      the rate and completeness of mitochondrial Ca(2+)
                      accumulation differed between different brain regions. For
                      the first time, we provide a detailed, regiospecific
                      analysis of Ca(2+)-dependent properties of brain
                      mitochondria. Regardless of their immunosuppressive impact,
                      CsA and its analogues improved mitochondrial functional
                      properties under control conditions. They also preserved
                      brain mitochondria against Ca(2+) overload-mediated PT and
                      functional impairments. Since Cs9 does not mediate
                      immunosuppression, it might be used as a more specific PT
                      inhibitor than CsA.},
      keywords     = {Animals / Brain: drug effects / Calcium: metabolism / Cell
                      Respiration: drug effects / Cyclosporine: metabolism /
                      Energy Metabolism: drug effects / Enzyme Inhibitors:
                      metabolism / Male / Mitochondria: drug effects / Rats /
                      Enzyme Inhibitors (NLM Chemicals) / Cyclosporine (NLM
                      Chemicals) / Calcium (NLM Chemicals)},
      cin          = {U Clinical Researchers - Magdeburg / AG Striggow},
      ddc          = {540},
      cid          = {I:(DE-2719)7000000 / I:(DE-2719)5000045},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 342 -
                      Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21167961},
      doi          = {10.1016/j.mito.2010.12.012},
      url          = {https://pub.dzne.de/record/136212},
}