guest ::
| Home > Publications Database > Effects of cyclosporine A and its immunosuppressive or non-immunosuppressive derivatives [D-Ser]8-CsA and Cs9 on mitochondria from different brain regions. > print |
| Home > Publications Database > Effects of cyclosporine A and its immunosuppressive or non-immunosuppressive derivatives [D-Ser]8-CsA and Cs9 on mitochondria from different brain regions. > print |
| 001 | 136212 | ||
| 005 | 20240614155534.0 | ||
| 024 | 7 | _ | |a 10.1016/j.mito.2010.12.012 |2 doi |
| 024 | 7 | _ | |a pmid:21167961 |2 pmid |
| 024 | 7 | _ | |a 1567-7249 |2 ISSN |
| 024 | 7 | _ | |a 1872-8278 |2 ISSN |
| 037 | _ | _ | |a DZNE-2020-02534 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |a Gizatullina, Zemfira Z |b 0 |
| 245 | _ | _ | |a Effects of cyclosporine A and its immunosuppressive or non-immunosuppressive derivatives [D-Ser]8-CsA and Cs9 on mitochondria from different brain regions. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2011 |b Elsevier Science |
| 264 | _ | 1 | |3 print |2 Crossref |b Elsevier BV |c 2011-05-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1718373296_614 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a We studied the functional properties of isolated brain mitochondria (BM) prepared from total rat brain (BM(total)) or from cerebral subregions under basal and Ca(2+) overload conditions in order to evaluate the effects of cyclosporine A (CsA) in a regiospecific manner. CsA-induced effects were compared with those of two derivatives-the none-immunosuppressive [O-(NH(2)(CH2)(5)NHC(O)CH(2))-D-Ser](8)-CsA (Cs9) and its congener, the immunosuppressive [D-Ser](8)-CsA. The glutamate/malate-dependent state 3 respiration of mitochondria (state 3(glu/mal)) differed in region-specific manner (cortex > striatum = cerebellum > substantia nigra > hippocampus), but was significantly increased by 1μM CsA (+21±5%) in all regions. Ca(2+) overload induced by addition of 20μM Ca(2+) caused a significant decrease of state 3(glu/mal) (-45 to -55%) which was almost completely prevented in the presence of 1μM CsA, 1μM Cs9 or 1μM [D-Ser](8)-CsA. Mitochondrial Ca(2+) accumulation thresholds linked to permeability transition (PT) as well as the rate and completeness of mitochondrial Ca(2+) accumulation differed between different brain regions. For the first time, we provide a detailed, regiospecific analysis of Ca(2+)-dependent properties of brain mitochondria. Regardless of their immunosuppressive impact, CsA and its analogues improved mitochondrial functional properties under control conditions. They also preserved brain mitochondria against Ca(2+) overload-mediated PT and functional impairments. Since Cs9 does not mediate immunosuppression, it might be used as a more specific PT inhibitor than CsA. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 1 |
| 542 | _ | _ | |i 2011-05-01 |2 Crossref |u https://www.elsevier.com/tdm/userlicense/1.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Enzyme Inhibitors |2 NLM Chemicals |
| 650 | _ | 7 | |a Cyclosporine |0 83HN0GTJ6D |2 NLM Chemicals |
| 650 | _ | 7 | |a Calcium |0 SY7Q814VUP |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Brain: drug effects |2 MeSH |
| 650 | _ | 2 | |a Calcium: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cell Respiration: drug effects |2 MeSH |
| 650 | _ | 2 | |a Cyclosporine: metabolism |2 MeSH |
| 650 | _ | 2 | |a Energy Metabolism: drug effects |2 MeSH |
| 650 | _ | 2 | |a Enzyme Inhibitors: metabolism |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mitochondria: drug effects |2 MeSH |
| 650 | _ | 2 | |a Rats |2 MeSH |
| 700 | 1 | _ | |a Gaynutdinov, Timur M |b 1 |
| 700 | 1 | _ | |a Svoboda, Hanno |b 2 |
| 700 | 1 | _ | |a Jerzembek, Doreen |b 3 |
| 700 | 1 | _ | |a Knabe, Annette |b 4 |
| 700 | 1 | _ | |a Vielhaber, Stefan |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Malesevic, Miroslav |b 6 |
| 700 | 1 | _ | |a Heinze, Hans-Jochen |0 P:(DE-2719)2260426 |b 7 |u dzne |
| 700 | 1 | _ | |a Fischer, Gunter |b 8 |
| 700 | 1 | _ | |a Striggow, Frank |0 P:(DE-2719)9000420 |b 9 |u dzne |
| 700 | 1 | _ | |a Gellerich, Frank N |0 P:(DE-HGF)0 |b 10 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1016/j.mito.2010.12.012 |b : Elsevier BV, 2011-05-01 |n 3 |p 421-429 |3 journal-article |2 Crossref |t Mitochondrion |v 11 |y 2011 |x 1567-7249 |
| 773 | _ | _ | |a 10.1016/j.mito.2010.12.012 |g Vol. 11, no. 3, p. 421 - 429 |0 PERI:(DE-600)2056923-3 |n 3 |q 11:3<421 - 429 |p 421-429 |t Mitochondrion |v 11 |y 2011 |x 1567-7249 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/136212/files/DZNE-2020-02534_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/136212/files/DZNE-2020-02534_Restricted.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:136212 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 7 |6 P:(DE-2719)2260426 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 9 |6 P:(DE-2719)9000420 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-344 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Disease Mechanisms and Model Systems |x 1 |
| 914 | 1 | _ | |y 2011 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b MITOCHONDRION : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |
| 920 | 1 | _ | |0 I:(DE-2719)7000000 |k U Clinical Researchers - Magdeburg |l U Clinical Researchers - Magdeburg |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)5000045 |k AG Striggow |l Neurodegeneration and Intervention Strategies |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)7000000 |
| 980 | _ | _ | |a I:(DE-2719)5000045 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|