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000136284 0247_ $$2doi$$a10.1016/j.neuron.2011.05.043
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000136284 041__ $$aEnglish
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000136284 1001_ $$0P:(DE-HGF)0$$aKrueppel, Roland$$b0
000136284 245__ $$aDendritic integration in hippocampal dentate granule cells.
000136284 260__ $$aNew York, NY$$bElsevier$$c2011
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000136284 520__ $$aHippocampal granule cells are important relay stations that transfer information from the entorhinal cortex into the hippocampus proper. This process is critically determined by the integrative properties of granule cell dendrites. However, their small diameter has so far hampered efforts to examine their properties directly. Using a combination of dual somatodendritic patch-clamp recordings and multiphoton glutamate uncaging, we now show that the integrative properties of granule cell dendrites differ substantially from other principal neurons. Due to a very strong dendritic voltage attenuation, the impact of individual synapses on granule cell output is low. At the same time, integration is linearized by voltage-dependent boosting mechanisms, only weakly affected by input synchrony, and independent of input location. These experiments establish that dentate granule cell dendritic properties are optimized for linear integration and strong attenuation of synaptic input from the entorhinal cortex, which may contribute to the sparse activity of granule cells in vivo.
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000136284 650_2 $$2MeSH$$aAction Potentials: physiology
000136284 650_2 $$2MeSH$$aAnimals
000136284 650_2 $$2MeSH$$aComputer Simulation: statistics & numerical data
000136284 650_2 $$2MeSH$$aDendrites: physiology
000136284 650_2 $$2MeSH$$aDentate Gyrus: cytology
000136284 650_2 $$2MeSH$$aDentate Gyrus: physiology
000136284 650_2 $$2MeSH$$aElectrophysiology: methods
000136284 650_2 $$2MeSH$$aExcitatory Postsynaptic Potentials: physiology
000136284 650_2 $$2MeSH$$aMicroscopy: methods
000136284 650_2 $$2MeSH$$aPatch-Clamp Techniques: methods
000136284 650_2 $$2MeSH$$aPyramidal Cells: physiology
000136284 650_2 $$2MeSH$$aRats
000136284 650_2 $$2MeSH$$aRats, Wistar
000136284 650_2 $$2MeSH$$aSynaptic Transmission: physiology
000136284 7001_ $$0P:(DE-2719)2810375$$aRemy, Stefan$$b1$$udzne
000136284 7001_ $$0P:(DE-HGF)0$$aBeck, Heinz$$b2$$eCorresponding author
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