TY  - JOUR
AU  - Krueppel, Roland
AU  - Remy, Stefan
AU  - Beck, Heinz
TI  - Dendritic integration in hippocampal dentate granule cells.
JO  - Neuron
VL  - 71
IS  - 3
SN  - 0896-6273
CY  - New York, NY
PB  - Elsevier
M1  - DZNE-2020-02606
SP  - 512-528
PY  - 2011
AB  - Hippocampal granule cells are important relay stations that transfer information from the entorhinal cortex into the hippocampus proper. This process is critically determined by the integrative properties of granule cell dendrites. However, their small diameter has so far hampered efforts to examine their properties directly. Using a combination of dual somatodendritic patch-clamp recordings and multiphoton glutamate uncaging, we now show that the integrative properties of granule cell dendrites differ substantially from other principal neurons. Due to a very strong dendritic voltage attenuation, the impact of individual synapses on granule cell output is low. At the same time, integration is linearized by voltage-dependent boosting mechanisms, only weakly affected by input synchrony, and independent of input location. These experiments establish that dentate granule cell dendritic properties are optimized for linear integration and strong attenuation of synaptic input from the entorhinal cortex, which may contribute to the sparse activity of granule cells in vivo.
KW  - Action Potentials: physiology
KW  - Animals
KW  - Computer Simulation: statistics & numerical data
KW  - Dendrites: physiology
KW  - Dentate Gyrus: cytology
KW  - Dentate Gyrus: physiology
KW  - Electrophysiology: methods
KW  - Excitatory Postsynaptic Potentials: physiology
KW  - Microscopy: methods
KW  - Patch-Clamp Techniques: methods
KW  - Pyramidal Cells: physiology
KW  - Rats
KW  - Rats, Wistar
KW  - Synaptic Transmission: physiology
LB  - PUB:(DE-HGF)16
C6  - pmid:21835347
DO  - DOI:10.1016/j.neuron.2011.05.043
UR  - https://pub.dzne.de/record/136284
ER  -