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@ARTICLE{Krueppel:136284,
      author       = {Krueppel, Roland and Remy, Stefan and Beck, Heinz},
      title        = {{D}endritic integration in hippocampal dentate granule
                      cells.},
      journal      = {Neuron},
      volume       = {71},
      number       = {3},
      issn         = {0896-6273},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-02606},
      pages        = {512-528},
      year         = {2011},
      abstract     = {Hippocampal granule cells are important relay stations that
                      transfer information from the entorhinal cortex into the
                      hippocampus proper. This process is critically determined by
                      the integrative properties of granule cell dendrites.
                      However, their small diameter has so far hampered efforts to
                      examine their properties directly. Using a combination of
                      dual somatodendritic patch-clamp recordings and multiphoton
                      glutamate uncaging, we now show that the integrative
                      properties of granule cell dendrites differ substantially
                      from other principal neurons. Due to a very strong dendritic
                      voltage attenuation, the impact of individual synapses on
                      granule cell output is low. At the same time, integration is
                      linearized by voltage-dependent boosting mechanisms, only
                      weakly affected by input synchrony, and independent of input
                      location. These experiments establish that dentate granule
                      cell dendritic properties are optimized for linear
                      integration and strong attenuation of synaptic input from
                      the entorhinal cortex, which may contribute to the sparse
                      activity of granule cells in vivo.},
      keywords     = {Action Potentials: physiology / Animals / Computer
                      Simulation: statistics $\&$ numerical data / Dendrites:
                      physiology / Dentate Gyrus: cytology / Dentate Gyrus:
                      physiology / Electrophysiology: methods / Excitatory
                      Postsynaptic Potentials: physiology / Microscopy: methods /
                      Patch-Clamp Techniques: methods / Pyramidal Cells:
                      physiology / Rats / Rats, Wistar / Synaptic Transmission:
                      physiology},
      cin          = {AG Remy},
      ddc          = {610},
      cid          = {I:(DE-2719)1013006},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21835347},
      doi          = {10.1016/j.neuron.2011.05.043},
      url          = {https://pub.dzne.de/record/136284},
}