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001     136284
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024 7 _ |a 10.1016/j.neuron.2011.05.043
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024 7 _ |a 0896-6273
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024 7 _ |a 1097-4199
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082 _ _ |a 610
100 1 _ |a Krueppel, Roland
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245 _ _ |a Dendritic integration in hippocampal dentate granule cells.
260 _ _ |a New York, NY
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264 _ 1 |3 print
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|b Elsevier BV
|c 2011-08-01
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520 _ _ |a Hippocampal granule cells are important relay stations that transfer information from the entorhinal cortex into the hippocampus proper. This process is critically determined by the integrative properties of granule cell dendrites. However, their small diameter has so far hampered efforts to examine their properties directly. Using a combination of dual somatodendritic patch-clamp recordings and multiphoton glutamate uncaging, we now show that the integrative properties of granule cell dendrites differ substantially from other principal neurons. Due to a very strong dendritic voltage attenuation, the impact of individual synapses on granule cell output is low. At the same time, integration is linearized by voltage-dependent boosting mechanisms, only weakly affected by input synchrony, and independent of input location. These experiments establish that dentate granule cell dendritic properties are optimized for linear integration and strong attenuation of synaptic input from the entorhinal cortex, which may contribute to the sparse activity of granule cells in vivo.
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542 _ _ |i 2011-08-01
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542 _ _ |i 2013-07-17
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650 _ 2 |a Action Potentials: physiology
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Computer Simulation: statistics & numerical data
|2 MeSH
650 _ 2 |a Dendrites: physiology
|2 MeSH
650 _ 2 |a Dentate Gyrus: cytology
|2 MeSH
650 _ 2 |a Dentate Gyrus: physiology
|2 MeSH
650 _ 2 |a Electrophysiology: methods
|2 MeSH
650 _ 2 |a Excitatory Postsynaptic Potentials: physiology
|2 MeSH
650 _ 2 |a Microscopy: methods
|2 MeSH
650 _ 2 |a Patch-Clamp Techniques: methods
|2 MeSH
650 _ 2 |a Pyramidal Cells: physiology
|2 MeSH
650 _ 2 |a Rats
|2 MeSH
650 _ 2 |a Rats, Wistar
|2 MeSH
650 _ 2 |a Synaptic Transmission: physiology
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700 1 _ |a Remy, Stefan
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700 1 _ |a Beck, Heinz
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773 1 8 |a 10.1016/j.neuron.2011.05.043
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|t Neuron
|v 71
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773 _ _ |a 10.1016/j.neuron.2011.05.043
|g Vol. 71, no. 3, p. 512 - 528
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856 4 _ |u https://pub.dzne.de/record/136284/files/DZNE-2020-02606_Restricted.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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