TY  - JOUR
AU  - Ikram, M Arfan
AU  - van der Lugt, Aad
AU  - Niessen, Wiro J
AU  - Krestin, Gabriel P
AU  - Koudstaal, Peter J
AU  - Hofman, Albert
AU  - Breteler, Monique M B
AU  - Vernooij, Meike W
TI  - The Rotterdam Scan Study: design and update up to 2012.
JO  - European journal of epidemiology
VL  - 26
IS  - 10
SN  - 0393-2990
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V.
M1  - DZNE-2020-02678
SP  - 811-824
PY  - 2011
AB  - Neuroimaging plays an important role in etiologic research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to unravel causes of neurological disease by performing neuroimaging in a population-based longitudinal setting. In 1995 and 1999 random subsets of the Rotterdam Study underwent neuroimaging, whereas from 2005 onwards MRI has been implemented into the core protocol of the Rotterdam Study. In this paper, we discuss the background and rationale of the Rotterdam Scan Study. We also describe the imaging protocol and post-processing techniques, and highlight the main findings to date. Finally, we make recommendations for future research, which will also be the main focus of investigation in the Rotterdam Scan Study.
KW  - Aged
KW  - Aged, 80 and over
KW  - Aging: pathology
KW  - Brain: blood supply
KW  - Brain: pathology
KW  - Brain Mapping
KW  - Chronic Disease
KW  - Female
KW  - Humans
KW  - Image Interpretation, Computer-Assisted
KW  - Image Processing, Computer-Assisted
KW  - Longitudinal Studies
KW  - Magnetic Resonance Imaging: methods
KW  - Male
KW  - Middle Aged
KW  - Nervous System Diseases: pathology
KW  - Netherlands
KW  - Neuroimaging
KW  - Population Surveillance
KW  - Risk Factors
LB  - PUB:(DE-HGF)16
C6  - pmid:22002080
C2  - pmc:PMC3218266
DO  - DOI:10.1007/s10654-011-9624-z
UR  - https://pub.dzne.de/record/136356
ER  -