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@ARTICLE{Ikram:136356,
      author       = {Ikram, M Arfan and van der Lugt, Aad and Niessen, Wiro J
                      and Krestin, Gabriel P and Koudstaal, Peter J and Hofman,
                      Albert and Breteler, Monique M B and Vernooij, Meike W},
      title        = {{T}he {R}otterdam {S}can {S}tudy: design and update up to
                      2012.},
      journal      = {European journal of epidemiology},
      volume       = {26},
      number       = {10},
      issn         = {0393-2990},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DZNE-2020-02678},
      pages        = {811-824},
      year         = {2011},
      abstract     = {Neuroimaging plays an important role in etiologic research
                      on neurological diseases in the elderly. The Rotterdam Scan
                      Study was initiated as part of the ongoing Rotterdam Study
                      with the aim to unravel causes of neurological disease by
                      performing neuroimaging in a population-based longitudinal
                      setting. In 1995 and 1999 random subsets of the Rotterdam
                      Study underwent neuroimaging, whereas from 2005 onwards MRI
                      has been implemented into the core protocol of the Rotterdam
                      Study. In this paper, we discuss the background and
                      rationale of the Rotterdam Scan Study. We also describe the
                      imaging protocol and post-processing techniques, and
                      highlight the main findings to date. Finally, we make
                      recommendations for future research, which will also be the
                      main focus of investigation in the Rotterdam Scan Study.},
      keywords     = {Aged / Aged, 80 and over / Aging: pathology / Brain: blood
                      supply / Brain: pathology / Brain Mapping / Chronic Disease
                      / Female / Humans / Image Interpretation, Computer-Assisted
                      / Image Processing, Computer-Assisted / Longitudinal Studies
                      / Magnetic Resonance Imaging: methods / Male / Middle Aged /
                      Nervous System Diseases: pathology / Netherlands /
                      Neuroimaging / Population Surveillance / Risk Factors},
      cin          = {AG Breteler 1},
      ddc          = {610},
      cid          = {I:(DE-2719)1012001},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22002080},
      pmc          = {pmc:PMC3218266},
      doi          = {10.1007/s10654-011-9624-z},
      url          = {https://pub.dzne.de/record/136356},
}