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@ARTICLE{Szentkiralyi:136364,
      author       = {Szentkiralyi, Andras and Fendrich, Konstanze and Hoffmann,
                      Wolfgang and Happe, Svenja and Berger, Klaus},
      title        = {{I}ncidence of restless legs syndrome in two
                      population-based cohort studies in {G}ermany.},
      journal      = {Sleep medicine},
      volume       = {12},
      number       = {9},
      issn         = {1389-9457},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-02686},
      pages        = {815-820},
      year         = {2011},
      abstract     = {Prospective data about the new-onset of restless legs
                      syndrome (RLS) are lacking. Our aim was to assess the
                      incidence rate of RLS in the general population.MethodsRLS,
                      defined by the minimal diagnostic criteria, was assessed
                      twice in two independently conducted prospective
                      population-based cohort studies in Germany. The Dortmund
                      Health Study (DHS) had a mean follow-up of 2.2 years, and
                      included 1312 participants, and the Study of Health in
                      Pomerania (SHIP) followed 4308 participants for, on average,
                      5.2 years. RLS was assessed during face-to-face interviews
                      in both studies at baseline and at follow-up in SHIP, and
                      with mailed questionnaires at follow-up in DHS.ResultsThe
                      age-standardized incidence rate of RLS was 22/1000
                      person-years (p-y) (cumulative incidence over the follow-up:
                      $9.1\%)$ in DHS and 9/1000 p-y (cumulative incidence:
                      $7.0\%)$ in SHIP. Women had a higher incidence rate than men
                      (DHS: 27/1000 p-y vs. 17/1000 p-y, p = 0.28; SHIP: 12/1000
                      p-y vs. 7/1000 p-y, p < 0.001). There was a linear increase
                      in RLS incidence rate with age in both studies. The
                      persistence of RLS symptoms from baseline to follow-up was
                      $47.4\%$ in DHS and $41.5\%$ in SHIP.ConclusionThe incidence
                      rate of RLS is high, while the persistence of RLS over time
                      is low, suggesting that RLS symptoms vary considerably. The
                      increased RLS incidence rate among women and the elderly is
                      consistent with previous prevalence data.},
      keywords     = {Adult / Age Distribution / Aged / Cohort Studies /
                      Comorbidity / Female / Follow-Up Studies / Germany:
                      epidemiology / Humans / Incidence / Male / Middle Aged /
                      Prevalence / Prospective Studies / Restless Legs Syndrome:
                      epidemiology / Sex Distribution / Surveys and
                      Questionnaires},
      cin          = {Witten common / AG Hoffmann},
      ddc          = {610},
      cid          = {I:(DE-2719)6000020 / I:(DE-2719)1510600},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22063473},
      doi          = {10.1016/j.sleep.2011.06.016},
      url          = {https://pub.dzne.de/record/136364},
}