TY  - JOUR
AU  - Teipel, Stefan J
AU  - Reuter, Sigrid
AU  - Stieltjes, Bram
AU  - Acosta-Cabronero, Julio
AU  - Ernemann, Ulrike
AU  - Fellgiebel, Andreas
AU  - Filippi, Massimo
AU  - Frisoni, Giovanni
AU  - Hentschel, Frank
AU  - Jessen, Frank
AU  - Klöppel, Stefan
AU  - Meindl, Thomas
AU  - Pouwels, Petra J W
AU  - Hauenstein, Karl-Heinz
AU  - Hampel, Harald
TI  - Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study.
JO  - Psychiatry research
VL  - 194
IS  - 3
SN  - 0925-4927
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2020-02714
SP  - 363-371
PY  - 2011
AB  - Diffusion tensor imaging (DTI) detects white matter damage in neuro-psychiatric disorders, but data on reliability of DTI measures across more than two scanners are still missing. In this study we assessed multicenter reproducibility of DTI acquisitions based on a physical phantom as well as brain scans across 16 scanners. In addition, we performed DTI scans in a group of 26 patients with clinically probable Alzheimer's disease (AD) and 12 healthy elderly controls at one single center. We determined the variability of fractional anisotropy (FA) measures using manually placed regions of interest as well as automated tract based spatial statistics and deformation based analysis. The coefficient of variation (CV) of FA was 6.9
KW  - Aged
KW  - Aged, 80 and over
KW  - Alzheimer Disease: diagnosis
KW  - Anisotropy
KW  - Bias
KW  - Brain: pathology
KW  - Brain Mapping
KW  - Diffusion Tensor Imaging: methods
KW  - Europe
KW  - Female
KW  - Humans
KW  - Middle Aged
KW  - Nerve Fibers, Myelinated: pathology
KW  - Phantoms, Imaging
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:22078796
DO  - DOI:10.1016/j.pscychresns.2011.05.012
UR  - https://pub.dzne.de/record/136392
ER  -