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001     136455
005     20240321220054.0
020 _ _ |a 978-3-642-24066-9 (print)
020 _ _ |a 978-3-642-24067-6 (electronic)
024 7 _ |a 10.1007/128_2011_160
|2 doi
024 7 _ |a pmid:21598098
|2 pmid
024 7 _ |a 0340-1022
|2 ISSN
024 7 _ |a 1436-5049
|2 ISSN
037 _ _ |a DZNE-2020-02777
041 _ _ |a English
082 _ _ |a 540
100 1 _ |a Resenberger, Ulrike K
|0 P:(DE-HGF)0
|b 0
245 _ _ |a Neuroprotective and neurotoxic signaling by the prion protein.
260 _ _ |a Heidelberg
|c 2011
|b Springer
264 _ 1 |3 online
|2 Crossref
|b Springer Berlin Heidelberg
|c 2011-05-20
264 _ 1 |3 print
|2 Crossref
|b Springer Berlin Heidelberg
|c 2011-01-01
295 1 0 |a Prion Proteins / Tatzelt, Jörg (Editor) ; Berlin, Heidelberg : Springer Berlin Heidelberg, 2012, Chapter 160 ; ISSN: 0340-1022=1436-5049 ; ISBN: 978-3-642-24066-9=978-3-642-24067-6 ; doi:10.1007/978-3-642-24067-6
300 _ _ |a 101 - 119
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Book
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|m book
336 7 _ |a Journal Article
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|m journal
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|s 1589891301_19479
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|x Review Article
336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
|0 0
|2 EndNote
490 0 _ |a Topics in Current Chemistry
|v 305
520 _ _ |a Prion diseases in humans and animals are characterized by progressive neurodegeneration and the formation of infectious particles called prions. Both features are intimately linked to a conformational transition of the cellular prion protein (PrP(C)) into aberrantly folded conformers with neurotoxic and self-replicating activities. Interestingly, there is increasing evidence that the infectious and neurotoxic properties of PrP conformers are not necessarily coupled. Transgenic mouse models revealed that some PrP mutants interfere with neuronal function in the absence of infectious prions. Vice versa, propagation of prions can occur without causing neurotoxicity. Consequently, it appears plausible that two partially independent pathways exist, one pathway leading to the propagation of infectious prions and another one that mediates neurotoxic signaling. In this review we will summarize current knowledge of neurotoxic PrP conformers and discuss the role of PrP(C) as a mediator of both stress-protective and neurotoxic signaling cascades.
536 _ _ |a 341 - Molecular Signaling (POF3-341)
|0 G:(DE-HGF)POF3-341
|c POF3-341
|f POF III
|x 0
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
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|c POF3-342
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588 _ _ |a Dataset connected to CrossRef Book Series, PubMed,
650 _ 7 |a Prions
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Models, Biological
|2 MeSH
650 _ 2 |a Mutation
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: metabolism
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
650 _ 2 |a Neurons: pathology
|2 MeSH
650 _ 2 |a Neurotoxicity Syndromes: metabolism
|2 MeSH
650 _ 2 |a Prion Diseases: metabolism
|2 MeSH
650 _ 2 |a Prion Diseases: pathology
|2 MeSH
650 _ 2 |a Prions: metabolism
|2 MeSH
650 _ 2 |a Protein Conformation
|2 MeSH
650 _ 2 |a Protein Denaturation
|2 MeSH
650 _ 2 |a Protein Folding
|2 MeSH
650 _ 2 |a Protein Structure, Tertiary
|2 MeSH
650 _ 2 |a Signal Transduction
|2 MeSH
700 1 _ |a Winklhofer, Konstanze F
|0 P:(DE-2719)9000369
|b 1
|u dzne
700 1 _ |a Tatzelt, Jörg
|0 P:(DE-2719)9000396
|b 2
|e Last author
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773 1 8 |a 10.1007/128_2011_160
|b : Springer Berlin Heidelberg, 2011-01-01
|p 101-119
|3 book-chapter
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|t Topics in Current Chemistry
|y 2011
|x 0340-1022
773 _ _ |a 10.1007/128_2011_160
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|v 305
|y 2011
|x 0340-1022
909 C O |o oai:pub.dzne.de:136455
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-341
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|v Molecular Signaling
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913 1 _ |a DE-HGF
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914 1 _ |y 2011
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999 C 5 |a 10.1523/JNEUROSCI.1115-05.2005
|9 -- missing cx lookup --
|2 Crossref
|o 10.1523/JNEUROSCI.1115-05.2005
999 C 5 |a 10.1016/j.nbd.2005.04.002
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.nbd.2005.04.002
999 C 5 |a 10.1161/01.STR.0000217262.03192.d4
|9 -- missing cx lookup --
|2 Crossref
|o 10.1161/01.STR.0000217262.03192.d4
999 C 5 |a 10.1111/j.1750-3639.2007.00061.x
|9 -- missing cx lookup --
|2 Crossref
|o 10.1111/j.1750-3639.2007.00061.x
999 C 5 |a 10.1074/jbc.M507327200
|9 -- missing cx lookup --
|2 Crossref
|o 10.1074/jbc.M507327200
999 C 5 |a 10.1002/jnr.21506
|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/jnr.21506
999 C 5 |a 10.1111/j.1471-4159.2006.03906.x
|9 -- missing cx lookup --
|2 Crossref
|o 10.1111/j.1471-4159.2006.03906.x
999 C 5 |a 10.1093/emboj/cdf324
|9 -- missing cx lookup --
|2 Crossref
|o 10.1093/emboj/cdf324
999 C 5 |a 10.1093/emboj/cdf325
|9 -- missing cx lookup --
|2 Crossref
|o 10.1093/emboj/cdf325
999 C 5 |a 10.1038/nm1297-1376
|9 -- missing cx lookup --
|2 Crossref
|o 10.1038/nm1297-1376
999 C 5 |a 10.1523/JNEUROSCI.2313-05.2005
|9 -- missing cx lookup --
|2 Crossref
|o 10.1523/JNEUROSCI.2313-05.2005
999 C 5 |a 10.1523/JNEUROSCI.1701-08.2008
|9 -- missing cx lookup --
|2 Crossref
|o 10.1523/JNEUROSCI.1701-08.2008
999 C 5 |a 10.1002/glia.20861
|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/glia.20861
999 C 5 |y 2010
|2 Crossref
|o VR Martins 2010
999 C 5 |a 10.1128/MCB.13.2.869
|9 -- missing cx lookup --
|2 Crossref
|o 10.1128/MCB.13.2.869
999 C 5 |a 10.1074/jbc.272.3.1876
|9 -- missing cx lookup --
|2 Crossref
|o 10.1074/jbc.272.3.1876
999 C 5 |a 10.1242/jcs.00905
|9 -- missing cx lookup --
|2 Crossref
|o 10.1242/jcs.00905
999 C 5 |a 10.1111/j.1471-4159.2007.04904.x
|9 -- missing cx lookup --
|2 Crossref
|o 10.1111/j.1471-4159.2007.04904.x
999 C 5 |a 10.1002/bies.200800151
|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/bies.200800151
999 C 5 |a 10.1074/jbc.M007114200
|9 -- missing cx lookup --
|2 Crossref
|o 10.1074/jbc.M007114200
999 C 5 |a 10.1073/pnas.051627998
|9 -- missing cx lookup --
|2 Crossref
|o 10.1073/pnas.051627998
999 C 5 |a 10.1073/pnas.251550798
|9 -- missing cx lookup --
|2 Crossref
|o 10.1073/pnas.251550798
999 C 5 |a 10.1093/emboj/20.4.694
|9 -- missing cx lookup --
|2 Crossref
|o 10.1093/emboj/20.4.694
999 C 5 |y 1999
|2 Crossref
|o N Nishida 1999
999 C 5 |y 2000
|2 Crossref
|o GL Silverman 2000
999 C 5 |a 10.1126/science.1094273
|9 -- missing cx lookup --
|2 Crossref
|o 10.1126/science.1094273
999 C 5 |a 10.1152/physrev.00023.2009
|9 -- missing cx lookup --
|2 Crossref
|o 10.1152/physrev.00023.2009
999 C 5 |a 10.1038/nn.2583
|9 -- missing cx lookup --
|2 Crossref
|o 10.1038/nn.2583
999 C 5 |a 10.1007/s004010000271
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s004010000271
999 C 5 |a 10.1046/j.1365-2990.2000.00239.x
|9 -- missing cx lookup --
|2 Crossref
|o 10.1046/j.1365-2990.2000.00239.x
999 C 5 |a 10.1007/s004010050870
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s004010050870
999 C 5 |a 10.1007/BF00713522
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/BF00713522
999 C 5 |a 10.1002/ana.10507
|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/ana.10507
999 C 5 |a 10.1016/j.neurobiolaging.2004.10.004
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neurobiolaging.2004.10.004
999 C 5 |a 10.1073/pnas.0609621104
|9 -- missing cx lookup --
|2 Crossref
|o 10.1073/pnas.0609621104
999 C 5 |a 10.1038/nature07761
|9 -- missing cx lookup --
|2 Crossref
|o 10.1038/nature07761
999 C 5 |a 10.1074/jbc.M110.145516
|9 -- missing cx lookup --
|2 Crossref
|o 10.1074/jbc.M110.145516
999 C 5 |a 10.1002/emmm.201000082
|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/emmm.201000082
999 C 5 |a 10.1073/pnas.0911829107
|9 -- missing cx lookup --
|2 Crossref
|o 10.1073/pnas.0911829107
999 C 5 |a 10.1523/JNEUROSCI.0395-10.2010
|9 -- missing cx lookup --
|2 Crossref
|o 10.1523/JNEUROSCI.0395-10.2010
999 C 5 |a 10.1038/nature09217
|9 -- missing cx lookup --
|2 Crossref
|o 10.1038/nature09217
999 C 5 |a 10.1186/1471-2202-11-130
|9 -- missing cx lookup --
|2 Crossref
|o 10.1186/1471-2202-11-130
999 C 5 |a 10.1016/j.neuron.2010.04.031
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neuron.2010.04.031
999 C 5 |a 10.1038/nrd2896
|9 -- missing cx lookup --
|2 Crossref
|o 10.1038/nrd2896
999 C 5 |a 10.1038/emboj.2011.86
|9 -- missing cx lookup --
|2 Crossref
|o 10.1038/emboj.2011.86
999 C 5 |y 2011
|2 Crossref
|o MF Tuite 2011
999 C 5 |y 2011
|2 Crossref
|o D Westaway 2011

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21