TY  - JOUR
AU  - Pilsl, Anna
AU  - Winklhofer, Konstanze F
TI  - Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease.
JO  - Acta neuropathologica
VL  - 123
IS  - 2
SN  - 0001-6322
CY  - Heidelberg
PB  - Springer
M1  - DZNE-2020-02785
SP  - 173-188
PY  - 2012
AB  - Mitochondria are dynamic organelles which are essential for many cellular processes, such as ATP production by oxidative phosphorylation, lipid metabolism, assembly of iron sulfur clusters, regulation of calcium homeostasis, and cell death pathways. The dynamic changes in mitochondrial morphology, connectivity, and subcellular distribution are critically dependent on a highly regulated fusion and fission machinery. Mitochondrial function, dynamics, and quality control are vital for the maintenance of neuronal integrity. Indeed, there is mounting evidence that mitochondrial dysfunction plays a central role in several neurodegenerative diseases. In particular, the identification of genes linked to rare familial variants of Parkinson's disease has fueled research on mitochondrial aspects of the disease etiopathogenesis. Studies on the function of parkin and PINK1, which are associated with autosomal recessive parkinsonism, provided compelling evidence that these proteins can functionally interact to maintain mitochondrial integrity and to promote clearance of damaged and dysfunctional mitochondria. In this review we will summarize current knowledge about the impact of parkin and PINK1 on mitochondria.
KW  - Animals
KW  - Humans
KW  - Mitochondrial Diseases: genetics
KW  - Mitochondrial Diseases: metabolism
KW  - Mitochondrial Diseases: physiopathology
KW  - Mitochondrial Proteins: genetics
KW  - Mitochondrial Proteins: physiology
KW  - Parkinson Disease: genetics
KW  - Parkinson Disease: metabolism
KW  - Parkinson Disease: physiopathology
KW  - Parkinsonian Disorders: genetics
KW  - Parkinsonian Disorders: metabolism
KW  - Parkinsonian Disorders: physiopathology
KW  - Protein Kinases: genetics
KW  - Protein Kinases: physiology
KW  - Ubiquitin-Protein Ligases: genetics
KW  - Ubiquitin-Protein Ligases: physiology
KW  - Mitochondrial Proteins (NLM Chemicals)
KW  - Ubiquitin-Protein Ligases (NLM Chemicals)
KW  - parkin protein (NLM Chemicals)
KW  - Protein Kinases (NLM Chemicals)
KW  - PTEN-induced putative kinase (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:22057787
DO  - DOI:10.1007/s00401-011-0902-3
UR  - https://pub.dzne.de/record/136463
ER  -