guest ::
| Home > Publications Database > Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. > print |
| Home > Publications Database > Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. > print |
| 001 | 136490 | ||
| 005 | 20240321220058.0 | ||
| 024 | 7 | _ | |a 10.1089/ars.2011.4173 |2 doi |
| 024 | 7 | _ | |a pmid:22229260 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC3329950 |2 pmc |
| 024 | 7 | _ | |a 1523-0864 |2 ISSN |
| 024 | 7 | _ | |a 1557-7716 |2 ISSN |
| 037 | _ | _ | |a DZNE-2020-02812 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |a Leuner, Kristina |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. |
| 260 | _ | _ | |a Larchmont, NY |c 2012 |b Liebert |
| 264 | _ | 1 | |3 print |2 Crossref |b Mary Ann Liebert Inc |c 2012-06-15 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1588242339_17522 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Intracellular amyloid beta (Aβ) oligomers and extracellular Aβ plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering Aβ production are largely unclear. We asked whether mitochondrion-derived reactive oxygen species (ROS) are sufficient to increase Aβ generation and thereby initiate a vicious cycle further impairing mitochondrial function.Complex I and III dysfunction was induced in a cell model using the respiratory inhibitors rotenone and antimycin, resulting in mitochondrial dysfunction and enhanced ROS levels. Both treatments lead to elevated levels of Aβ. Presence of an antioxidant rescued mitochondrial function and reduced formation of Aβ, demonstrating that the observed effects depended on ROS. Conversely, cells overproducing Aβ showed impairment of mitochondrial function such as comprised mitochondrial respiration, strongly altered morphology, and reduced intracellular mobility of mitochondria. Again, the capability of these cells to generate Aβ was partly reduced by an antioxidant, indicating that Aβ formation was also ROS dependent. Moreover, mice with a genetic defect in complex I, or AD mice treated with a complex I inhibitor, showed enhanced Aβ levels in vivo.We show for the first time that mitochondrion-derived ROS are sufficient to trigger Aβ production in vitro and in vivo.Several lines of evidence show that mitochondrion-derived ROS result in enhanced amyloidogenic amyloid precursor protein processing, and that Aβ itself leads to mitochondrial dysfunction and increased ROS levels. We propose that starting from mitochondrial dysfunction a vicious cycle is triggered that contributes to the pathogenesis of sporadic AD. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Amyloid beta-Peptides |2 NLM Chemicals |
| 650 | _ | 7 | |a Reactive Oxygen Species |2 NLM Chemicals |
| 650 | _ | 7 | |a Rotenone |0 03L9OT429T |2 NLM Chemicals |
| 650 | _ | 7 | |a antimycin |0 11118-72-2 |2 NLM Chemicals |
| 650 | _ | 7 | |a Antimycin A |0 642-15-9 |2 NLM Chemicals |
| 650 | _ | 7 | |a Amyloid Precursor Protein Secretases |0 EC 3.4.- |2 NLM Chemicals |
| 650 | _ | 7 | |a Aspartic Acid Endopeptidases |0 EC 3.4.23.- |2 NLM Chemicals |
| 650 | _ | 7 | |a BACE1 protein, human |0 EC 3.4.23.46 |2 NLM Chemicals |
| 650 | _ | 2 | |a Alzheimer Disease: metabolism |2 MeSH |
| 650 | _ | 2 | |a Amyloid Precursor Protein Secretases: genetics |2 MeSH |
| 650 | _ | 2 | |a Amyloid Precursor Protein Secretases: metabolism |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Peptides: metabolism |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Antimycin A: analogs & derivatives |2 MeSH |
| 650 | _ | 2 | |a Antimycin A: pharmacology |2 MeSH |
| 650 | _ | 2 | |a Aspartic Acid Endopeptidases: genetics |2 MeSH |
| 650 | _ | 2 | |a Aspartic Acid Endopeptidases: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cell Line |2 MeSH |
| 650 | _ | 2 | |a Enzyme-Linked Immunosorbent Assay |2 MeSH |
| 650 | _ | 2 | |a Flow Cytometry |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Mutant Strains |2 MeSH |
| 650 | _ | 2 | |a Microscopy, Confocal |2 MeSH |
| 650 | _ | 2 | |a Mitochondria: drug effects |2 MeSH |
| 650 | _ | 2 | |a Mitochondria: metabolism |2 MeSH |
| 650 | _ | 2 | |a Reactive Oxygen Species: metabolism |2 MeSH |
| 650 | _ | 2 | |a Rotenone: pharmacology |2 MeSH |
| 700 | 1 | _ | |a Schütt, Tanja |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Kurz, Christopher |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Eckert, Schamim H |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Schiller, Carola |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Occhipinti, Angelo |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Mai, Sören |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Jendrach, Marina |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Eckert, Gunter P |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Kruse, Shane E |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Palmiter, Richard D |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Brandt, Ulrich |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Dröse, Stephan |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Wittig, Ilka |0 P:(DE-HGF)0 |b 13 |
| 700 | 1 | _ | |a Willem, Michael |0 P:(DE-2719)9000433 |b 14 |u dzne |
| 700 | 1 | _ | |a Haass, Christian |0 P:(DE-2719)2202037 |b 15 |u dzne |
| 700 | 1 | _ | |a Reichert, Andreas S |0 P:(DE-HGF)0 |b 16 |
| 700 | 1 | _ | |a Müller, Walter E |0 P:(DE-HGF)0 |b 17 |
| 773 | 1 | 8 | |a 10.1089/ars.2011.4173 |b : Mary Ann Liebert Inc, 2012-06-15 |n 12 |p 1421-1433 |3 journal-article |2 Crossref |t Antioxidants & Redox Signaling |v 16 |y 2012 |x 1523-0864 |
| 773 | _ | _ | |a 10.1089/ars.2011.4173 |g Vol. 16, no. 12, p. 1421 - 1433 |0 PERI:(DE-600)2039747-1 |n 12 |q 16:12<1421 - 1433 |p 1421-1433 |t Antioxidants & redox signaling |v 16 |y 2012 |x 1523-0864 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329950 |
| 909 | C | O | |o oai:pub.dzne.de:136490 |p VDB |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 14 |6 P:(DE-2719)9000433 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 15 |6 P:(DE-2719)2202037 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |2 G:(DE-HGF)POF3-300 |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2012 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b ANTIOXID REDOX SIGN : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b ANTIOXID REDOX SIGN : 2017 |
| 920 | 1 | _ | |0 I:(DE-2719)5000048 |k Ext LMU |l Ludwig-Maximilians-University |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1110007 |k AG Haass old |l ALS, FTLD and Zebrafish models |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)5000048 |
| 980 | _ | _ | |a I:(DE-2719)5000015 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|