%0 Journal Article
%A Sartorius, Tina
%A Lutz, Stefan Z
%A Hoene, Miriam
%A Waak, Jens
%A Peter, Andreas
%A Weigert, Cora
%A Rammensee, Hans-Georg
%A Kahle, Philipp J
%A Häring, Hans-Ulrich
%A Hennige, Anita M
%T Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architecture.
%J The FASEB journal
%V 26
%N 5
%@ 0892-6638
%C Bethesda, Md.
%I FASEB
%M DZNE-2020-02833
%P 1799-1809
%D 2012
%X Impaired insulin action in the brain represents an early step in the progression toward type 2 diabetes, and elevated levels of saturated free fatty acids are known to impair insulin action in prediabetic subjects. One potential mediator that links fatty acids to inflammation and insulin resistance is the Toll-like receptor (TLR) family. Therefore, C3H/HeJ/TLR2-KO (TLR2/4-deficient) mice were fed a high-fat diet (HFD), and insulin action in the brain as well as cortical and locomotor activity was analyzed by using telemetric implants. TLR2/4-deficient mice were protected from HFD-induced glucose intolerance and insulin resistance in the brain and displayed an improvement in cortical and locomotor activity that was not observed in C3H/HeJ mice. Sleep recordings revealed a 42
%K Animals
%K Astrocytes: metabolism
%K Brain: physiology
%K Cells, Cultured
%K Electroencephalography
%K Glucose Tolerance Test
%K Insulin: physiology
%K Insulin Resistance
%K Interleukin-6: immunology
%K Interleukin-6: physiology
%K Locomotion
%K Mice
%K Mice, Inbred C3H
%K Mice, Knockout
%K Osteopontin: physiology
%K Phosphorylation
%K Proto-Oncogene Proteins c-akt: metabolism
%K Real-Time Polymerase Chain Reaction
%K Sleep
%K Toll-Like Receptor 2: genetics
%K Toll-Like Receptor 2: physiology
%K Toll-Like Receptor 4: genetics
%K Toll-Like Receptor 4: physiology
%K Insulin (NLM Chemicals)
%K Interleukin-6 (NLM Chemicals)
%K Tlr2 protein, mouse (NLM Chemicals)
%K Tlr4 protein, mouse (NLM Chemicals)
%K Toll-Like Receptor 2 (NLM Chemicals)
%K Toll-Like Receptor 4 (NLM Chemicals)
%K Osteopontin (NLM Chemicals)
%K Proto-Oncogene Proteins c-akt (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:22278939
%R 10.1096/fj.11-191023
%U https://pub.dzne.de/record/136511