TY  - JOUR
AU  - Sartorius, Tina
AU  - Lutz, Stefan Z
AU  - Hoene, Miriam
AU  - Waak, Jens
AU  - Peter, Andreas
AU  - Weigert, Cora
AU  - Rammensee, Hans-Georg
AU  - Kahle, Philipp J
AU  - Häring, Hans-Ulrich
AU  - Hennige, Anita M
TI  - Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architecture.
JO  - The FASEB journal
VL  - 26
IS  - 5
SN  - 0892-6638
CY  - Bethesda, Md.
PB  - FASEB
M1  - DZNE-2020-02833
SP  - 1799-1809
PY  - 2012
AB  - Impaired insulin action in the brain represents an early step in the progression toward type 2 diabetes, and elevated levels of saturated free fatty acids are known to impair insulin action in prediabetic subjects. One potential mediator that links fatty acids to inflammation and insulin resistance is the Toll-like receptor (TLR) family. Therefore, C3H/HeJ/TLR2-KO (TLR2/4-deficient) mice were fed a high-fat diet (HFD), and insulin action in the brain as well as cortical and locomotor activity was analyzed by using telemetric implants. TLR2/4-deficient mice were protected from HFD-induced glucose intolerance and insulin resistance in the brain and displayed an improvement in cortical and locomotor activity that was not observed in C3H/HeJ mice. Sleep recordings revealed a 42
KW  - Animals
KW  - Astrocytes: metabolism
KW  - Brain: physiology
KW  - Cells, Cultured
KW  - Electroencephalography
KW  - Glucose Tolerance Test
KW  - Insulin: physiology
KW  - Insulin Resistance
KW  - Interleukin-6: immunology
KW  - Interleukin-6: physiology
KW  - Locomotion
KW  - Mice
KW  - Mice, Inbred C3H
KW  - Mice, Knockout
KW  - Osteopontin: physiology
KW  - Phosphorylation
KW  - Proto-Oncogene Proteins c-akt: metabolism
KW  - Real-Time Polymerase Chain Reaction
KW  - Sleep
KW  - Toll-Like Receptor 2: genetics
KW  - Toll-Like Receptor 2: physiology
KW  - Toll-Like Receptor 4: genetics
KW  - Toll-Like Receptor 4: physiology
KW  - Insulin (NLM Chemicals)
KW  - Interleukin-6 (NLM Chemicals)
KW  - Tlr2 protein, mouse (NLM Chemicals)
KW  - Tlr4 protein, mouse (NLM Chemicals)
KW  - Toll-Like Receptor 2 (NLM Chemicals)
KW  - Toll-Like Receptor 4 (NLM Chemicals)
KW  - Osteopontin (NLM Chemicals)
KW  - Proto-Oncogene Proteins c-akt (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:22278939
DO  - DOI:10.1096/fj.11-191023
UR  - https://pub.dzne.de/record/136511
ER  -