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| Home > Publications Database > Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architecture. > print |
| 001 | 136511 | ||
| 005 | 20240321220101.0 | ||
| 024 | 7 | _ | |a 10.1096/fj.11-191023 |2 doi |
| 024 | 7 | _ | |a pmid:22278939 |2 pmid |
| 024 | 7 | _ | |a 0892-6638 |2 ISSN |
| 024 | 7 | _ | |a 1530-6860 |2 ISSN |
| 037 | _ | _ | |a DZNE-2020-02833 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Sartorius, Tina |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architecture. |
| 260 | _ | _ | |a Bethesda, Md. |c 2012 |b FASEB |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2012-01-25 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2012-05-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1585653304_17219 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Impaired insulin action in the brain represents an early step in the progression toward type 2 diabetes, and elevated levels of saturated free fatty acids are known to impair insulin action in prediabetic subjects. One potential mediator that links fatty acids to inflammation and insulin resistance is the Toll-like receptor (TLR) family. Therefore, C3H/HeJ/TLR2-KO (TLR2/4-deficient) mice were fed a high-fat diet (HFD), and insulin action in the brain as well as cortical and locomotor activity was analyzed by using telemetric implants. TLR2/4-deficient mice were protected from HFD-induced glucose intolerance and insulin resistance in the brain and displayed an improvement in cortical and locomotor activity that was not observed in C3H/HeJ mice. Sleep recordings revealed a 42% increase in rapid eye movement sleep in the deficient mice during daytime, and these mice spent 41% more time awake during the night period. Treatment of control mice with a neutralizing IL-6 antibody improved insulin action in the brain as well as cortical activity and diminished osteopontin protein to levels of the TLR2/4-deficient mice. Together, our data suggest that the lack of functional TLR2/4 protects mice from a fat-mediated impairment in insulin action, brain activity, locomotion, and sleep architecture by an IL-6/osteopontin-dependent mechanism. |
| 536 | _ | _ | |a 345 - Population Studies and Genetics (POF3-345) |0 G:(DE-HGF)POF3-345 |c POF3-345 |f POF III |x 0 |
| 542 | _ | _ | |i 2012-01-25 |2 Crossref |u http://onlinelibrary.wiley.com/termsAndConditions#vor |
| 542 | _ | _ | |i 2012-01-25 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Insulin |2 NLM Chemicals |
| 650 | _ | 7 | |a Interleukin-6 |2 NLM Chemicals |
| 650 | _ | 7 | |a Tlr2 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Tlr4 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Toll-Like Receptor 2 |2 NLM Chemicals |
| 650 | _ | 7 | |a Toll-Like Receptor 4 |2 NLM Chemicals |
| 650 | _ | 7 | |a Osteopontin |0 106441-73-0 |2 NLM Chemicals |
| 650 | _ | 7 | |a Proto-Oncogene Proteins c-akt |0 EC 2.7.11.1 |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Astrocytes: metabolism |2 MeSH |
| 650 | _ | 2 | |a Brain: physiology |2 MeSH |
| 650 | _ | 2 | |a Cells, Cultured |2 MeSH |
| 650 | _ | 2 | |a Electroencephalography |2 MeSH |
| 650 | _ | 2 | |a Glucose Tolerance Test |2 MeSH |
| 650 | _ | 2 | |a Insulin: physiology |2 MeSH |
| 650 | _ | 2 | |a Insulin Resistance |2 MeSH |
| 650 | _ | 2 | |a Interleukin-6: immunology |2 MeSH |
| 650 | _ | 2 | |a Interleukin-6: physiology |2 MeSH |
| 650 | _ | 2 | |a Locomotion |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C3H |2 MeSH |
| 650 | _ | 2 | |a Mice, Knockout |2 MeSH |
| 650 | _ | 2 | |a Osteopontin: physiology |2 MeSH |
| 650 | _ | 2 | |a Phosphorylation |2 MeSH |
| 650 | _ | 2 | |a Proto-Oncogene Proteins c-akt: metabolism |2 MeSH |
| 650 | _ | 2 | |a Real-Time Polymerase Chain Reaction |2 MeSH |
| 650 | _ | 2 | |a Sleep |2 MeSH |
| 650 | _ | 2 | |a Toll-Like Receptor 2: genetics |2 MeSH |
| 650 | _ | 2 | |a Toll-Like Receptor 2: physiology |2 MeSH |
| 650 | _ | 2 | |a Toll-Like Receptor 4: genetics |2 MeSH |
| 650 | _ | 2 | |a Toll-Like Receptor 4: physiology |2 MeSH |
| 700 | 1 | _ | |a Lutz, Stefan Z |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Hoene, Miriam |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Waak, Jens |0 P:(DE-2719)9000332 |b 3 |u dzne |
| 700 | 1 | _ | |a Peter, Andreas |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Weigert, Cora |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Rammensee, Hans-Georg |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Kahle, Philipp J |0 P:(DE-2719)2810803 |b 7 |u dzne |
| 700 | 1 | _ | |a Häring, Hans-Ulrich |0 P:(DE-HGF)0 |b 8 |e Corresponding author |
| 700 | 1 | _ | |a Hennige, Anita M |0 P:(DE-HGF)0 |b 9 |
| 773 | 1 | 8 | |a 10.1096/fj.11-191023 |b : Wiley, 2012-01-25 |n 5 |p 1799-1809 |3 journal-article |2 Crossref |t The FASEB Journal |v 26 |y 2012 |x 0892-6638 |
| 773 | _ | _ | |a 10.1096/fj.11-191023 |g Vol. 26, no. 5, p. 1799 - 1809 |0 PERI:(DE-600)1468876-1 |n 5 |q 26:5<1799 - 1809 |p 1799-1809 |t The FASEB journal |v 26 |y 2012 |x 0892-6638 |
| 909 | C | O | |o oai:pub.dzne.de:136511 |p VDB |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 3 |6 P:(DE-2719)9000332 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 7 |6 P:(DE-2719)2810803 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-345 |2 G:(DE-HGF)POF3-300 |v Population Studies and Genetics |x 0 |
| 914 | 1 | _ | |y 2012 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b FASEB J : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b FASEB J : 2017 |
| 920 | 1 | _ | |0 I:(DE-2719)1210000-4 |k AG Kahle 2 |l Functional Neurogenetics |x 0 |
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| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1210000-4 |
| 980 | _ | _ | |a UNRESTRICTED |
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