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000136531 0247_ $$2doi$$a10.1007/s00062-011-0099-9
000136531 0247_ $$2pmid$$apmid:21971720
000136531 0247_ $$2ISSN$$a0939-7116
000136531 0247_ $$2ISSN$$a1615-6706
000136531 0247_ $$2ISSN$$a1869-1439
000136531 0247_ $$2ISSN$$a1869-1447
000136531 037__ $$aDZNE-2020-02853
000136531 041__ $$aEnglish
000136531 1001_ $$0P:(DE-HGF)0$$aMöhlenbruch, M.$$b0$$eCorresponding author
000136531 245__ $$aMechanical thrombectomy compared to local-intraarterial thrombolysis in carotid T and middle cerebral artery occlusions: a single center experience.
000136531 260__ $$aMünchen$$bUrban & Vogel$$c2012
000136531 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2011-10-05
000136531 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2012-06-01
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000136531 520__ $$aThe aim of the study was to examine the effects of mechanical thrombectomy using the Solitaire stent in patients with thromboembolic occlusions of the intracranial carotid artery bifurcation (carotid T) or middle cerebral artery (MCA) and to compare the results with a historical cohort treated with local intraarterial thrombolysis using urokinase.The time intervals from stroke onset to treatment, recanalization rates, occlusion sites, recanalization times and functional outcomes on the modified Rankin scale at 3 months in 25 patients treated with the Solitaire stent between 2010 and 2011 were evaluated. The data were compared with those of a historical cohort of 62 patients treated with local intraarterial thrombolysis between 1992 and 2001.A total of 15 out of 25 (60%) patients treated with mechanical thrombectomy and 25 out of 62 (40%) treated with local intraarterial thrombolysis achieved a modified Rankin score of  ≤2 (p = 0.07). Occlusion sites, intervals from stroke onset to treatment and rates of parenchymal hematomas, 3 out of 25 (12%) versus 8 out of 62 (13%), were similar in both cohorts while the recanalization rate was significantly higher, 22 out of 25 (88%) versus 33 of 62 (53%), in the mechanical thrombectomy group (p ≤ 0.01).The data show that mechanical thrombectomy is superior to local intraarterial thrombolysis with respect to the recanalization rate in patients with thrombeoembolic carotid T or MCA occlusions.
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000136531 650_7 $$2NLM Chemicals$$aFibrinolytic Agents
000136531 650_7 $$0EC 3.4.21.73$$2NLM Chemicals$$aUrokinase-Type Plasminogen Activator
000136531 650_2 $$2MeSH$$aAged
000136531 650_2 $$2MeSH$$aCarotid Stenosis: diagnostic imaging
000136531 650_2 $$2MeSH$$aCarotid Stenosis: therapy
000136531 650_2 $$2MeSH$$aFibrinolytic Agents: administration & dosage
000136531 650_2 $$2MeSH$$aHumans
000136531 650_2 $$2MeSH$$aInfarction, Middle Cerebral Artery: diagnostic imaging
000136531 650_2 $$2MeSH$$aInfarction, Middle Cerebral Artery: therapy
000136531 650_2 $$2MeSH$$aInjections, Intra-Arterial
000136531 650_2 $$2MeSH$$aMechanical Thrombolysis: methods
000136531 650_2 $$2MeSH$$aMiddle Aged
000136531 650_2 $$2MeSH$$aRadiography
000136531 650_2 $$2MeSH$$aThrombolytic Therapy: methods
000136531 650_2 $$2MeSH$$aTreatment Outcome
000136531 650_2 $$2MeSH$$aUrokinase-Type Plasminogen Activator: administration & dosage
000136531 7001_ $$0P:(DE-HGF)0$$aSeifert, M.$$b1
000136531 7001_ $$0P:(DE-HGF)0$$aOkulla, T.$$b2
000136531 7001_ $$0P:(DE-HGF)0$$aWüllner, U.$$b3
000136531 7001_ $$0P:(DE-HGF)0$$aHadizadeh, D. R.$$b4
000136531 7001_ $$0P:(DE-HGF)0$$aNelles, M.$$b5
000136531 7001_ $$0P:(DE-HGF)0$$aGreschus, S.$$b6
000136531 7001_ $$0P:(DE-HGF)0$$aWilhelm, K.$$b7
000136531 7001_ $$0P:(DE-HGF)0$$aSchild, H. H.$$b8
000136531 7001_ $$0P:(DE-2719)2810314$$aKlockgether, T.$$b9$$udzne
000136531 7001_ $$0P:(DE-HGF)0$$aUrbach, H.$$b10
000136531 77318 $$2Crossref$$3journal-article$$a10.1007/s00062-011-0099-9$$b : Springer Science and Business Media LLC, 2011-10-05$$n2$$p141-147$$tClinical Neuroradiology$$v22$$x1869-1439$$y2011
000136531 773__ $$0PERI:(DE-600)2232347-8$$a10.1007/s00062-011-0099-9$$gVol. 22, no. 2, p. 141 - 147$$n2$$p141-147$$q22:2<141 - 147$$tClinical neuroradiology$$v22$$x1869-1439$$y2011
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