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@ARTICLE{Mhlenbruch:136531,
      author       = {Möhlenbruch, M. and Seifert, M. and Okulla, T. and
                      Wüllner, U. and Hadizadeh, D. R. and Nelles, M. and
                      Greschus, S. and Wilhelm, K. and Schild, H. H. and
                      Klockgether, T. and Urbach, H.},
      title        = {{M}echanical thrombectomy compared to local-intraarterial
                      thrombolysis in carotid {T} and middle cerebral artery
                      occlusions: a single center experience.},
      journal      = {Clinical neuroradiology},
      volume       = {22},
      number       = {2},
      issn         = {1869-1439},
      address      = {München},
      publisher    = {Urban $\&$ Vogel},
      reportid     = {DZNE-2020-02853},
      pages        = {141-147},
      year         = {2012},
      abstract     = {The aim of the study was to examine the effects of
                      mechanical thrombectomy using the Solitaire stent in
                      patients with thromboembolic occlusions of the intracranial
                      carotid artery bifurcation (carotid T) or middle cerebral
                      artery (MCA) and to compare the results with a historical
                      cohort treated with local intraarterial thrombolysis using
                      urokinase.The time intervals from stroke onset to treatment,
                      recanalization rates, occlusion sites, recanalization times
                      and functional outcomes on the modified Rankin scale at 3
                      months in 25 patients treated with the Solitaire stent
                      between 2010 and 2011 were evaluated. The data were compared
                      with those of a historical cohort of 62 patients treated
                      with local intraarterial thrombolysis between 1992 and
                      2001.A total of 15 out of 25 $(60\%)$ patients treated with
                      mechanical thrombectomy and 25 out of 62 $(40\%)$ treated
                      with local intraarterial thrombolysis achieved a modified
                      Rankin score of  ≤2 (p = 0.07). Occlusion sites,
                      intervals from stroke onset to treatment and rates of
                      parenchymal hematomas, 3 out of 25 $(12\%)$ versus 8 out of
                      62 $(13\%),$ were similar in both cohorts while the
                      recanalization rate was significantly higher, 22 out of 25
                      $(88\%)$ versus 33 of 62 $(53\%),$ in the mechanical
                      thrombectomy group (p ≤ 0.01).The data show that
                      mechanical thrombectomy is superior to local intraarterial
                      thrombolysis with respect to the recanalization rate in
                      patients with thrombeoembolic carotid T or MCA occlusions.},
      keywords     = {Aged / Carotid Stenosis: diagnostic imaging / Carotid
                      Stenosis: therapy / Fibrinolytic Agents: administration $\&$
                      dosage / Humans / Infarction, Middle Cerebral Artery:
                      diagnostic imaging / Infarction, Middle Cerebral Artery:
                      therapy / Injections, Intra-Arterial / Mechanical
                      Thrombolysis: methods / Middle Aged / Radiography /
                      Thrombolytic Therapy: methods / Treatment Outcome /
                      Urokinase-Type Plasminogen Activator: administration $\&$
                      dosage / Fibrinolytic Agents (NLM Chemicals) /
                      Urokinase-Type Plasminogen Activator (NLM Chemicals)},
      cin          = {Patient studies, Bonn},
      cid          = {I:(DE-2719)1011101},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21971720},
      doi          = {10.1007/s00062-011-0099-9},
      url          = {https://pub.dzne.de/record/136531},
}