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000136539 0247_ $$2doi$$a10.1111/j.1471-4159.2012.07713.x
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000136539 0247_ $$2ISSN$$a0022-3042
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000136539 037__ $$aDZNE-2020-02861
000136539 041__ $$aEnglish
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000136539 1001_ $$0P:(DE-HGF)0$$aGruss, Michael$$b0$$eCorresponding author
000136539 245__ $$a9-Methyl-β-carboline-induced cognitive enhancement is associated with elevated hippocampal dopamine levels and dendritic and synaptic proliferation.
000136539 260__ $$aOxford$$bWiley-Blackwell$$c2012
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000136539 520__ $$aβ-Carbolines (BCs) belong to the heterogenous family of carbolines, which have been found exogenously, that is, in various fruits, meats, tobacco smoke, alcohol and coffee, but also endogenously, that is, blood, brain and CSF. These exogenous and endogenous BCs and some of their metabolites can exert neurotoxic effects, however, an unexpected stimulatory effect of 9-methyl-β-carboline (9-me-BC) on dopaminergic neurons in primary mesencephalic cultures was recently discovered. The aim of the present study was to extend our knowledge on the stimulatory effects of 9-me-BC and to test the hypothesis that 9-me-BC may act as a cognitive enhancer. We found that 10 days (but not 5 days) of pharmacological treatment with 9-me-BC (i) improves spatial learning in the radial maze, (ii) elevates dopamine levels in the hippocampal formation, and (iii) results after 10 days of treatment in elongated, more complex dendritic trees and higher spine numbers on granule neurons in the dentate gyrus of 9-me-BC-treated rats. Our results demonstrate that beyond its neuroprotective/neurorestorative and anti-inflammatory effects, 9-me-BC acts as a cognitive enhancer in a hippocampus-dependent task, and that the behavioral effects may be associated with a stimulatory impact on hippocampal dopamine levels and dendritic and synaptic proliferation.
000136539 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000136539 650_7 $$2NLM Chemicals$$a9-methyl-beta-carboline
000136539 650_7 $$2NLM Chemicals$$aCarbolines
000136539 650_7 $$2NLM Chemicals$$aCentral Nervous System Stimulants
000136539 650_7 $$0VTD58H1Z2X$$2NLM Chemicals$$aDopamine
000136539 650_2 $$2MeSH$$aAnimals
000136539 650_2 $$2MeSH$$aCarbolines: pharmacology
000136539 650_2 $$2MeSH$$aCentral Nervous System Stimulants: pharmacology
000136539 650_2 $$2MeSH$$aChromatography, High Pressure Liquid
000136539 650_2 $$2MeSH$$aCognition: drug effects
000136539 650_2 $$2MeSH$$aDendrites: drug effects
000136539 650_2 $$2MeSH$$aDopamine: metabolism
000136539 650_2 $$2MeSH$$aFemale
000136539 650_2 $$2MeSH$$aHippocampus: drug effects
000136539 650_2 $$2MeSH$$aHippocampus: metabolism
000136539 650_2 $$2MeSH$$aHippocampus: ultrastructure
000136539 650_2 $$2MeSH$$aMaze Learning: drug effects
000136539 650_2 $$2MeSH$$aRats
000136539 650_2 $$2MeSH$$aRats, Wistar
000136539 650_2 $$2MeSH$$aSynapses: drug effects
000136539 7001_ $$aAppenroth, Dorothea$$b1
000136539 7001_ $$0P:(DE-2719)2809916$$aFlubacher, Armin$$b2$$udzne
000136539 7001_ $$aEnzensperger, Christoph$$b3
000136539 7001_ $$aBock, Jörg$$b4
000136539 7001_ $$aFleck, Christian$$b5
000136539 7001_ $$aGille, Gabriele$$b6
000136539 7001_ $$aBraun, Katharina$$b7
000136539 77318 $$2Crossref$$3journal-article$$a10.1111/j.1471-4159.2012.07713.x$$b : Wiley, 2012-06-01$$n6$$p924-931$$tJournal of Neurochemistry$$v121$$x0022-3042$$y2012
000136539 773__ $$0PERI:(DE-600)2020528-4$$a10.1111/j.1471-4159.2012.07713.x$$gVol. 121, no. 6, p. 924 - 931$$n6$$p924-931$$q121:6<924 - 931$$tJournal of neurochemistry$$v121$$x0022-3042$$y2012
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