000136624 001__ 136624
000136624 005__ 20240321220116.0
000136624 0247_ $$2doi$$a10.1111/j.1600-0854.2012.01392.x
000136624 0247_ $$2pmid$$apmid:22758778
000136624 0247_ $$2ISSN$$a1398-9219
000136624 0247_ $$2ISSN$$a1600-0854
000136624 0247_ $$2altmetric$$aaltmetric:821268
000136624 037__ $$aDZNE-2020-02946
000136624 041__ $$aEnglish
000136624 082__ $$a570
000136624 1001_ $$0P:(DE-HGF)0$$aCuartero, Yasmina$$b0
000136624 245__ $$aRetromer regulates postendocytic sorting of β-secretase in polarized Madin-Darby canine kidney cells.
000136624 260__ $$aOxford$$bWiley-Blackwell$$c2012
000136624 264_1 $$2Crossref$$3online$$bWiley$$c2012-07-25
000136624 264_1 $$2Crossref$$3print$$bWiley$$c2012-10-01
000136624 3367_ $$2DRIVER$$aarticle
000136624 3367_ $$2DataCite$$aOutput Types/Journal article
000136624 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1592207200_2129
000136624 3367_ $$2BibTeX$$aARTICLE
000136624 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000136624 3367_ $$00$$2EndNote$$aJournal Article
000136624 520__ $$aβ-Amyloid (Aβ) peptides are generated from the successive proteolytic processing of the amyloid precursor protein (APP) by the β-APP cleaving enzyme (BACE or β-secretase) and the γ-secretase complex. Initial cleavage of APP by BACE leads into the amyloidogenic pathway, causing or exacerbating Alzheimer's disease. Therefore, their intracellular traffic can determine how easily and frequently BACE has access to and cleaves APP. Here, we have used polarized Madin-Darby canine kidney (MDCK) cells stably expressing APP and BACE to examine the regulation of their polarized trafficking by retromer, a protein complex previously implicated in their endosome-to-Golgi transport. Our data show that retromer interacts with BACE and regulates its postendocytic sorting in polarized MDCK cells. Depleting retromer, inhibiting retromer function, or preventing BACE interaction with retromer, alters trafficking of BACE, which thereby increases its localization in the early endocytic compartment. As a result, this slows endocytosis of apically localized BACE, promoting its recycling and apical-to-basolateral transcytosis, which increases APP/BACE interaction and subsequent cleavage of APP toward generation and secretion of Aβ peptides.
000136624 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000136624 542__ $$2Crossref$$i2015-09-01$$uhttp://doi.wiley.com/10.1002/tdm_license_1.1
000136624 588__ $$aDataset connected to CrossRef, PubMed,
000136624 650_7 $$2NLM Chemicals$$aAmyloid beta-Protein Precursor
000136624 650_7 $$2NLM Chemicals$$aMultiprotein Complexes
000136624 650_7 $$2NLM Chemicals$$aVesicular Transport Proteins
000136624 650_7 $$0EC 3.4.-$$2NLM Chemicals$$aAmyloid Precursor Protein Secretases
000136624 650_2 $$2MeSH$$aAmyloid Precursor Protein Secretases: chemistry
000136624 650_2 $$2MeSH$$aAmyloid Precursor Protein Secretases: genetics
000136624 650_2 $$2MeSH$$aAmyloid Precursor Protein Secretases: metabolism
000136624 650_2 $$2MeSH$$aAmyloid beta-Protein Precursor: metabolism
000136624 650_2 $$2MeSH$$aAnimals
000136624 650_2 $$2MeSH$$aCell Line
000136624 650_2 $$2MeSH$$aDogs
000136624 650_2 $$2MeSH$$aEndocytosis
000136624 650_2 $$2MeSH$$aEndosomes: metabolism
000136624 650_2 $$2MeSH$$aGolgi Apparatus: metabolism
000136624 650_2 $$2MeSH$$aMadin Darby Canine Kidney Cells
000136624 650_2 $$2MeSH$$aMice
000136624 650_2 $$2MeSH$$aMultiprotein Complexes: metabolism
000136624 650_2 $$2MeSH$$aMutation
000136624 650_2 $$2MeSH$$aProtein Interaction Domains and Motifs
000136624 650_2 $$2MeSH$$aProtein Transport
000136624 650_2 $$2MeSH$$aVesicular Transport Proteins: metabolism
000136624 7001_ $$0P:(DE-HGF)0$$aMellado, Maravillas$$b1
000136624 7001_ $$0P:(DE-2719)9000368$$aCapell, Anja$$b2$$udzne
000136624 7001_ $$0P:(DE-HGF)0$$aAlvarez-Dolado, Manuel$$b3
000136624 7001_ $$0P:(DE-HGF)0$$aVerges, Marcel$$b4$$eCorresponding author
000136624 77318 $$2Crossref$$3journal-article$$a10.1111/j.1600-0854.2012.01392.x$$b : Wiley, 2012-07-25$$n10$$p1393-1410$$tTraffic$$v13$$x1398-9219$$y2012
000136624 773__ $$0PERI:(DE-600)2020962-9$$a10.1111/j.1600-0854.2012.01392.x$$gVol. 13, no. 10, p. 1393 - 1410$$n10$$p1393-1410$$q13:10<1393 - 1410$$tTraffic$$v13$$x1398-9219$$y2012
000136624 909CO $$ooai:pub.dzne.de:136624$$pVDB
000136624 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000368$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000136624 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000136624 9141_ $$y2012
000136624 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bTRAFFIC : 2017
000136624 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000136624 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000136624 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000136624 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000136624 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000136624 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000136624 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000136624 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000136624 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000136624 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000136624 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000136624 9201_ $$0I:(DE-2719)5000048$$kExt LMU$$lExt Ludwig-Maximilians-University$$x0
000136624 980__ $$ajournal
000136624 980__ $$aVDB
000136624 980__ $$aI:(DE-2719)5000048
000136624 980__ $$aUNRESTRICTED
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/hmg/ddq160$$o10.1093/hmg/ddq160
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1072994$$o10.1126/science.1072994
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2174/156720510793611592$$o10.2174/156720510793611592
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0959-4388(00)00253-1$$o10.1016/S0959-4388(00)00253-1
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2006.09.001$$o10.1016/j.neuron.2006.09.001
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1600-0854.2012.01332.x$$o10.1111/j.1600-0854.2012.01332.x
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1034/j.1600-0854.2002.31101.x$$o10.1034/j.1600-0854.2002.31101.x
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.4161/cam.3.1.7254$$o10.4161/cam.3.1.7254
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0955-0674(00)00120-4$$o10.1016/S0955-0674(00)00120-4
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.91.4.1564$$o10.1073/pnas.91.4.1564
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.128.4.537$$o10.1083/jcb.128.4.537
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M109119200$$o10.1074/jbc.M109119200
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1600-0854.2006.00526.x$$o10.1111/j.1600-0854.2006.00526.x
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/ana.20667$$o10.1002/ana.20667
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M411296200$$o10.1074/jbc.M411296200
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ng1943$$o10.1038/ng1943
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tcb.2004.12.004$$o10.1016/j.tcb.2004.12.004
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ceb.2008.03.009$$o10.1016/j.ceb.2008.03.009
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1600-0854.2011.01201.x$$o10.1111/j.1600-0854.2011.01201.x
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1600-0854.2008.00777.x$$o10.1111/j.1600-0854.2008.00777.x
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.200312034$$o10.1083/jcb.200312034
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.200312055$$o10.1083/jcb.200312055
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M110.170217$$o10.1074/jbc.M110.170217
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/1750-1326-5-40$$o10.1186/1750-1326-5-40
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.201105109$$o10.1083/jcb.201105109
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.nbd.2012.03.030$$o10.1016/j.nbd.2012.03.030
000136624 999C5 $$2Crossref$$oVerges 2008$$y2008
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2008.11.007$$o10.1016/j.neuron.2008.11.007
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00221-011-2870-1$$o10.1007/s00221-011-2870-1
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.mcn.2011.06.013$$o10.1016/j.mcn.2011.06.013
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrn2620$$o10.1038/nrn2620
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0092-8674(90)90240-F$$o10.1016/0092-8674(90)90240-F
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0896-6273(00)80468-7$$o10.1016/S0896-6273(00)80468-7
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.yexcr.2006.11.010$$o10.1016/j.yexcr.2006.11.010
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.286.5440.735$$o10.1126/science.286.5440.735
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.151.2.297$$o10.1083/jcb.151.2.297
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrn2168$$o10.1038/nrn2168
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncb1153$$o10.1038/ncb1153
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1242/jcs.00090$$o10.1242/jcs.00090
000136624 999C5 $$2Crossref$$oHaass 1993$$y1993
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.270.6.2419$$o10.1074/jbc.270.6.2419
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1242/jcs.00643$$o10.1242/jcs.00643
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1600-0854.2006.00396.x$$o10.1111/j.1600-0854.2006.00396.x
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0014-5793(02)03052-1$$o10.1016/S0014-5793(02)03052-1
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1146/annurev.biochem.72.121801.161800$$o10.1146/annurev.biochem.72.121801.161800
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M011116200$$o10.1074/jbc.M011116200
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1600-0854.2008.00834.x$$o10.1111/j.1600-0854.2008.00834.x
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0896-6273(01)80021-0$$o10.1016/S0896-6273(01)80021-0
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0896-6273(03)00629-9$$o10.1016/S0896-6273(03)00629-9
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.87.4.1561$$o10.1073/pnas.87.4.1561
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/414643a$$o10.1038/414643a
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroscience.2004.08.028$$o10.1016/j.neuroscience.2004.08.028
000136624 999C5 $$2Crossref$$oLo 1994$$y1994
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.270.8.4058$$o10.1074/jbc.270.8.4058
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.270.51.30310$$o10.1074/jbc.270.51.30310
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M004175200$$o10.1074/jbc.M004175200
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1100745108$$o10.1073/pnas.1100745108
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1091/mbc.E11-11-0944$$o10.1091/mbc.E11-11-0944
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.bbrc.2007.12.015$$o10.1016/j.bbrc.2007.12.015
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1242/jcs.009654$$o10.1242/jcs.009654
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1128/MCB.00815-07$$o10.1128/MCB.00815-07
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.2272-11.2012$$o10.1523/JNEUROSCI.2272-11.2012
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.3872-10.2010$$o10.1523/JNEUROSCI.3872-10.2010
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M606455200$$o10.1074/jbc.M606455200
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/bi052120v$$o10.1021/bi052120v
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1600-0854.2011.01284.x$$o10.1111/j.1600-0854.2011.01284.x
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1096/fj.09-146357$$o10.1096/fj.09-146357
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0802545105$$o10.1073/pnas.0802545105
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.devcel.2010.01.015$$o10.1016/j.devcel.2010.01.015
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neurobiolaging.2004.09.018$$o10.1016/j.neurobiolaging.2004.09.018
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ydbio.2011.09.009$$o10.1016/j.ydbio.2011.09.009
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cub.2011.05.007$$o10.1016/j.cub.2011.05.007
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.mcn.2005.02.008$$o10.1016/j.mcn.2005.02.008
000136624 999C5 $$2Crossref$$oShahar A Dissection and Tissue Culture Manual of the Nervous System 1990$$tA Dissection and Tissue Culture Manual of the Nervous System$$y1990
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0076-6879(06)19001-1$$o10.1016/S0076-6879(06)19001-1
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nprot.2008.55$$o10.1038/nprot.2008.55
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/jnr.20963$$o10.1002/jnr.20963
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M003202200$$o10.1074/jbc.M003202200
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0091-679X(08)61178-4$$o10.1016/S0091-679X(08)61178-4
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1091/mbc.11.12.4105$$o10.1091/mbc.11.12.4105
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.4396-06.2007$$o10.1523/JNEUROSCI.4396-06.2007
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/35041097$$o10.1038/35041097
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.5354-05.2006$$o10.1523/JNEUROSCI.5354-05.2006
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/1471-2091-7-8$$o10.1186/1471-2091-7-8
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/35078543$$o10.1038/35078543
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.125.1.67$$o10.1083/jcb.125.1.67
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1152/ajpcell.00462.2010$$o10.1152/ajpcell.00462.2010
000136624 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0076-6879(05)04029-2$$o10.1016/S0076-6879(05)04029-2