%0 Journal Article
%A Keller, Margaux F
%A Saad, Mohamad
%A Bras, Jose
%A Bettella, Francesco
%A Nicolaou, Nayia
%A Simón-Sánchez, Javier
%A Mittag, Florian
%A Büchel, Finja
%A Sharma, Manu
%A Gibbs, J Raphael
%A Schulte, Claudia
%A Moskvina, Valentina
%A Durr, Alexandra
%A Holmans, Peter
%A Kilarski, Laura L
%A Guerreiro, Rita
%A Hernandez, Dena G
%A Brice, Alexis
%A Ylikotila, Pauli
%A Stefánsson, Hreinn
%A Majamaa, Kari
%A Morris, Huw R
%A Williams, Nigel
%A Gasser, Thomas
%A Heutink, Peter
%A Wood, Nicholas W
%A Hardy, John
%A Martinez, Maria
%A Singleton, Andrew B
%A Nalls, Michael A
%A Consortium, International Parkinson's Disease Genomics
%A 2, Wellcome Trust Case Control Consortium
%A Keller, Margaux F
%A Nalls, Michael A
%A Plagnol, Vincent
%A Sheerin, Una-Marie
%A Saad, Mohamad
%A Simón-Sánchez, Javier
%A Lesage, Suzanne
%A Sveinbjörnsdóttir, Sigurlaug
%A Arepalli, Sampath
%A Ben-Shlomo, Yoav
%A Berendse, Henk W
%A Berg, Daniela
%A Bhatia, Kailash
%A de Bie, Rob M A
%A Biffi, Alessandro
%A Bloem, Bas
%A Bochdanovits, Zoltan
%A Bonin, Michael
%A Bras, Jose
%A Brockmann, Kathrin
%A Brooks, Janet
%A Burn, David J
%A Charlesworth, Gavin
%A Chen, Honglei
%A Chinnery, Patrick F
%A Chong, Sean
%A Clarke, Carl E
%A Cookson, Mark R
%A Cooper, J Mark
%A Corvol, Jean Christophe
%A Counsell, Carl
%A Damier, Philippe
%A Dartigues, Jean-François
%A Segalen, Victor
%A Deloukas, Panos
%A Deuschl, Günther
%A Dexter, David T
%A van Dijk, Karin D
%A Dillman, Allissa
%A Durif, Frank
%A Montpied, Gabriel
%A Edkins, Sarah
%A Evans, Jonathan R
%A Foltynie, Thomas
%A Gao, Jianjun
%A Gardner, Michelle
%A Gibbs, J Raphael
%A Goate, Alison
%A Gray, Emma
%A Guerreiro, Rita
%A Gústafsson, Omar
%A Harris, Clare
%A van Hilten, Jacobus J
%A Hofman, Albert
%A Hollenbeck, Albert
%A Holton, Janice
%A Hu, Michele
%A Huang, Xuemei
%A Huber, Heiko
%A Hudson, Gavin
%A Hunt, Sarah E
%A Huttenlocher, Johanna
%A Illig, Thomas
%A Jónsson, Pálmi V
%A Lambert, Jean-Charles
%A Langford, Cordelia
%A Lees, Andrew
%A Lichtner, Peter
%A Limousin, Patricia
%A Lopez, Grisel
%A Lorenz, Delia
%A McNeill, Alisdair
%A Moorby, Catriona
%A Moore, Matthew
%A Morris, Huw R
%A Morrison, Karen E
%A Mudanohwo, Ese
%A O'Sullivan, Sean S
%A Pearson, Justin
%A Perlmutter, Joel S
%A Pétursson, Hjörvar
%A Pollak, Pierre
%A Post, Bart
%A Potter, Simon
%A Ravina, Bernard
%A Revesz, Tamas
%A Riess, Olaf
%A Rivadeneira, Fernando
%A Rizzu, Patrizia
%A Ryten, Mina
%A Sawcer, Stephen
%A Schapira, Anthony
%A Scheffer, Hans
%A Shaw, Karen
%A Shoulson, Ira
%A Sidransky, Ellen
%A Smith, Colin
%A Spencer, Chris C A
%A Stefánsson, Hreinn
%A Steinberg, Stacy
%A Stockton, Joanna D
%A Strange, Amy
%A Talbot, Kevin
%A Tanner, Carlie M
%A Tashakkori-Ghanbaria, Avazeh
%A Tison, François
%A Trabzuni, Daniah
%A Traynor, Bryan J
%A Uitterlinden, André G
%A Velseboer, Daan
%A Vidailhet, Marie
%A Walker, Robert
%A van de Warrenburg, Bart
%A Wickremaratchi, Mirdhu
%A Williams, Nigel
%A Williams-Gray, Caroline H
%A Winder-Rhodes, Sophie
%A Stefánsson, Kári
%A Martinez, Maria
%A Sabatier, Paul
%A Hardy, John
%A Brice, Alexis
%A Singleton, Andrew B
%A Wood, Nicholas W
%A Donnelly, Peter
%A Barroso, Ines
%A Blackwell, Jenefer M
%A Bramon, Elvira
%A Brown, Matthew A
%A Casas, Juan P
%A Corvin, Aiden
%A Deloukas, Panos
%A Duncanson, Audrey
%A Jankowski, Janusz
%A Markus, Hugh S
%A Mathew, Christopher G
%A Palmer, Colin N A
%A Plomin, Robert
%A Rautanen, Anna
%A Sawcer, Stephen J
%A Trembath, Richard C
%A Viswanathan, Ananth C
%A Wood, Nicholas W
%A Spencer, Chris C A
%A Band, Gavin
%A Bellenguez, Céline
%A Freeman, Colin
%A Hellenthal, Garrett
%A Giannoulatou, Eleni
%A Pirinen, Matti
%A Pearson, Richard
%A Strange, Amy
%A Su, Zhan
%A Vukcevic, Damjan
%A Donnelly, Peter
%A Langford, Cordelia
%A Hunt, Sarah E
%A Edkins, Sarah
%A Gwilliam, Rhian
%A Blackburn, Hannah
%A Bumpstead, Suzannah J
%A Dronov, Serge
%A Gillman, Matthew
%A Gray, Emma
%A Hammond, Naomi
%A Jayakumar, Alagurevathi
%A McCann, Owen T
%A Liddle, Jennifer
%A Potter, Simon C
%A Ravindrarajah, Radhi
%A Ricketts, Michelle
%A Waller, Matthew
%A Weston, Paul
%A Widaa, Sara
%A Whittaker, Pamela
%A Barroso, Ines
%A Deloukas, Panos
%T Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
%J Human molecular genetics
%V 21
%N 22
%@ 0964-6906
%C Oxford
%I Oxford Univ. Press
%M DZNE-2020-02990
%P 4996-5009
%D 2012
%X Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits; however, a great deal of the heritable variation associated with common traits remains unaccounted for within the genome. Genome-wide complex trait analysis (GCTA) is a statistical method that applies a linear mixed model to estimate phenotypic variance of complex traits explained by genome-wide SNPs, including those not associated with the trait in a GWAS. We applied GCTA to 8 cohorts containing 7096 case and 19 455 control individuals of European ancestry in order to examine the missing heritability present in Parkinson's disease (PD). We meta-analyzed our initial results to produce robust heritability estimates for PD types across cohorts. Our results identify 27
%K Adult
%K Aged
%K Aged, 80 and over
%K European Continental Ancestry Group: genetics
%K Female
%K Genetic Predisposition to Disease
%K Genetic Variation
%K Genome-Wide Association Study
%K Humans
%K Male
%K Middle Aged
%K Multifactorial Inheritance
%K Parkinson Disease: genetics
%K Quantitative Trait, Heritable
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:22892372
%2 pmc:PMC3576713
%R 10.1093/hmg/dds335
%U https://pub.dzne.de/record/136668