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000136755 0247_ $$2doi$$a10.1016/j.neuron.2012.09.038
000136755 0247_ $$2pmid$$apmid:23259946
000136755 0247_ $$2ISSN$$a0896-6273
000136755 0247_ $$2ISSN$$a1097-4199
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000136755 037__ $$aDZNE-2020-03077
000136755 041__ $$aEnglish
000136755 082__ $$a610
000136755 1001_ $$0P:(DE-2719)2810272$$aFlynn, Kevin C$$b0$$eFirst author$$udzne
000136755 245__ $$aADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain.
000136755 260__ $$aNew York, NY$$bElsevier$$c2012
000136755 264_1 $$2Crossref$$3print$$bElsevier BV$$c2012-12-01
000136755 3367_ $$2DRIVER$$aarticle
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000136755 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1710770327_18975
000136755 3367_ $$2BibTeX$$aARTICLE
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000136755 520__ $$aNeurites are the characteristic structural element of neurons that will initiate brain connectivity and elaborate information. Early in development, neurons are spherical cells but this symmetry is broken through the initial formation of neurites. This fundamental step is thought to rely on actin and microtubule dynamics. However, it is unclear which aspects of the complex actin behavior control neuritogenesis and which molecular mechanisms are involved. Here, we demonstrate that augmented actin retrograde flow and protrusion dynamics facilitate neurite formation. Our data indicate that a single family of actin regulatory proteins, ADF/Cofilin, provides the required control of actin retrograde flow and dynamics to form neurites. In particular, the F-actin severing activity of ADF/Cofilin organizes space for the protrusion and bundling of microtubules, the backbone of neurites. Our data reveal how ADF/Cofilin organizes the cytoskeleton to drive actin retrograde flow and thus break the spherical shape of neurons.
000136755 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000136755 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x1
000136755 542__ $$2Crossref$$i2012-12-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
000136755 542__ $$2Crossref$$i2013-12-20$$uhttps://www.elsevier.com/open-access/userlicense/1.0/
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000136755 650_7 $$2NLM Chemicals$$aActin Depolymerizing Factors
000136755 650_7 $$2NLM Chemicals$$aActins
000136755 650_7 $$2NLM Chemicals$$aDestrin
000136755 650_7 $$2NLM Chemicals$$aDstn protein, mouse
000136755 650_2 $$2MeSH$$aActin Depolymerizing Factors: physiology
000136755 650_2 $$2MeSH$$aActins: metabolism
000136755 650_2 $$2MeSH$$aAnimals
000136755 650_2 $$2MeSH$$aBiological Transport
000136755 650_2 $$2MeSH$$aCell Growth Processes: physiology
000136755 650_2 $$2MeSH$$aCell Shape: physiology
000136755 650_2 $$2MeSH$$aCells, Cultured
000136755 650_2 $$2MeSH$$aCerebral Cortex: cytology
000136755 650_2 $$2MeSH$$aCerebral Cortex: embryology
000136755 650_2 $$2MeSH$$aDestrin: physiology
000136755 650_2 $$2MeSH$$aGrowth Cones: metabolism
000136755 650_2 $$2MeSH$$aHippocampus: cytology
000136755 650_2 $$2MeSH$$aHippocampus: embryology
000136755 650_2 $$2MeSH$$aIn Vitro Techniques
000136755 650_2 $$2MeSH$$aMice
000136755 650_2 $$2MeSH$$aMice, Knockout
000136755 650_2 $$2MeSH$$aMicrotubules: physiology
000136755 650_2 $$2MeSH$$aNeurites: metabolism
000136755 650_2 $$2MeSH$$aNeurogenesis: physiology
000136755 7001_ $$0P:(DE-2719)2810276$$aHellal, Farida$$b1$$udzne
000136755 7001_ $$0P:(DE-HGF)0$$aNeukirchen, Dorothee$$b2
000136755 7001_ $$0P:(DE-HGF)0$$aJacob, Sonja$$b3
000136755 7001_ $$0P:(DE-2719)2442036$$aTahirovic, Sabina$$b4$$udzne
000136755 7001_ $$0P:(DE-2719)2810386$$aDupraz, Sebastian$$b5$$udzne
000136755 7001_ $$0P:(DE-2719)2810277$$aStern, Sina$$b6$$udzne
000136755 7001_ $$0P:(DE-HGF)0$$aGarvalov, Boyan K$$b7
000136755 7001_ $$0P:(DE-HGF)0$$aGurniak, Christine$$b8
000136755 7001_ $$0P:(DE-HGF)0$$aShaw, Alisa E$$b9
000136755 7001_ $$0P:(DE-2719)2810287$$aMeyn, Liane$$b10$$udzne
000136755 7001_ $$0P:(DE-HGF)0$$aWedlich-Söldner, Roland$$b11
000136755 7001_ $$0P:(DE-HGF)0$$aBamburg, James R$$b12
000136755 7001_ $$0P:(DE-HGF)0$$aSmall, J Victor$$b13
000136755 7001_ $$0P:(DE-HGF)0$$aWitke, Walter$$b14
000136755 7001_ $$0P:(DE-2719)2810270$$aBradke, Frank$$b15$$eLast author$$udzne
000136755 77318 $$2Crossref$$3journal-article$$a10.1016/j.neuron.2012.09.038$$b : Elsevier BV, 2012-12-01$$n6$$p1091-1107$$tNeuron$$v76$$x0896-6273$$y2012
000136755 773__ $$0PERI:(DE-600)2001944-0$$a10.1016/j.neuron.2012.09.038$$gVol. 76, no. 6, p. 1091 - 1107$$n6$$p1091-1107$$q76:6<1091 - 1107$$tNeuron$$v76$$x0896-6273$$y2012
000136755 8564_ $$uhttps://www.sciencedirect.com/science/article/pii/S0896627312008975
000136755 8564_ $$uhttps://pub.dzne.de/record/136755/files/DZNE-2020-03077_Restricted.pdf
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000136755 9141_ $$y2012
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