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@ARTICLE{Flynn:136755,
      author       = {Flynn, Kevin C and Hellal, Farida and Neukirchen, Dorothee
                      and Jacob, Sonja and Tahirovic, Sabina and Dupraz, Sebastian
                      and Stern, Sina and Garvalov, Boyan K and Gurniak, Christine
                      and Shaw, Alisa E and Meyn, Liane and Wedlich-Söldner,
                      Roland and Bamburg, James R and Small, J Victor and Witke,
                      Walter and Bradke, Frank},
      title        = {{ADF}/cofilin-mediated actin retrograde flow directs
                      neurite formation in the developing brain.},
      journal      = {Neuron},
      volume       = {76},
      number       = {6},
      issn         = {0896-6273},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-03077},
      pages        = {1091-1107},
      year         = {2012},
      abstract     = {Neurites are the characteristic structural element of
                      neurons that will initiate brain connectivity and elaborate
                      information. Early in development, neurons are spherical
                      cells but this symmetry is broken through the initial
                      formation of neurites. This fundamental step is thought to
                      rely on actin and microtubule dynamics. However, it is
                      unclear which aspects of the complex actin behavior control
                      neuritogenesis and which molecular mechanisms are involved.
                      Here, we demonstrate that augmented actin retrograde flow
                      and protrusion dynamics facilitate neurite formation. Our
                      data indicate that a single family of actin regulatory
                      proteins, ADF/Cofilin, provides the required control of
                      actin retrograde flow and dynamics to form neurites. In
                      particular, the F-actin severing activity of ADF/Cofilin
                      organizes space for the protrusion and bundling of
                      microtubules, the backbone of neurites. Our data reveal how
                      ADF/Cofilin organizes the cytoskeleton to drive actin
                      retrograde flow and thus break the spherical shape of
                      neurons.},
      keywords     = {Actin Depolymerizing Factors: physiology / Actins:
                      metabolism / Animals / Biological Transport / Cell Growth
                      Processes: physiology / Cell Shape: physiology / Cells,
                      Cultured / Cerebral Cortex: cytology / Cerebral Cortex:
                      embryology / Destrin: physiology / Growth Cones: metabolism
                      / Hippocampus: cytology / Hippocampus: embryology / In Vitro
                      Techniques / Mice / Mice, Knockout / Microtubules:
                      physiology / Neurites: metabolism / Neurogenesis: physiology
                      / Actin Depolymerizing Factors (NLM Chemicals) / Actins (NLM
                      Chemicals) / Destrin (NLM Chemicals) / Dstn protein, mouse
                      (NLM Chemicals)},
      cin          = {AG Bradke / AG Tahirovic},
      ddc          = {610},
      cid          = {I:(DE-2719)1013002 / I:(DE-2719)1140003},
      pnm          = {341 - Molecular Signaling (POF3-341) / 342 - Disease
                      Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-341 / G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23259946},
      doi          = {10.1016/j.neuron.2012.09.038},
      url          = {https://pub.dzne.de/record/136755},
}