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001     136755
005     20240321220129.0
024 7 _ |a 10.1016/j.neuron.2012.09.038
|2 doi
024 7 _ |a pmid:23259946
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024 7 _ |a 0896-6273
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024 7 _ |a 1097-4199
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024 7 _ |a altmetric:1137558
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037 _ _ |a DZNE-2020-03077
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Flynn, Kevin C
|0 P:(DE-2719)2810272
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245 _ _ |a ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain.
260 _ _ |a New York, NY
|c 2012
|b Elsevier
264 _ 1 |3 print
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|b Elsevier BV
|c 2012-12-01
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Neurites are the characteristic structural element of neurons that will initiate brain connectivity and elaborate information. Early in development, neurons are spherical cells but this symmetry is broken through the initial formation of neurites. This fundamental step is thought to rely on actin and microtubule dynamics. However, it is unclear which aspects of the complex actin behavior control neuritogenesis and which molecular mechanisms are involved. Here, we demonstrate that augmented actin retrograde flow and protrusion dynamics facilitate neurite formation. Our data indicate that a single family of actin regulatory proteins, ADF/Cofilin, provides the required control of actin retrograde flow and dynamics to form neurites. In particular, the F-actin severing activity of ADF/Cofilin organizes space for the protrusion and bundling of microtubules, the backbone of neurites. Our data reveal how ADF/Cofilin organizes the cytoskeleton to drive actin retrograde flow and thus break the spherical shape of neurons.
536 _ _ |a 341 - Molecular Signaling (POF3-341)
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542 _ _ |i 2012-12-01
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|u https://www.elsevier.com/tdm/userlicense/1.0/
542 _ _ |i 2013-12-20
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|u https://www.elsevier.com/open-access/userlicense/1.0/
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650 _ 7 |a Actin Depolymerizing Factors
|2 NLM Chemicals
650 _ 7 |a Actins
|2 NLM Chemicals
650 _ 7 |a Destrin
|2 NLM Chemicals
650 _ 7 |a Dstn protein, mouse
|2 NLM Chemicals
650 _ 2 |a Actin Depolymerizing Factors: physiology
|2 MeSH
650 _ 2 |a Actins: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Biological Transport
|2 MeSH
650 _ 2 |a Cell Growth Processes: physiology
|2 MeSH
650 _ 2 |a Cell Shape: physiology
|2 MeSH
650 _ 2 |a Cells, Cultured
|2 MeSH
650 _ 2 |a Cerebral Cortex: cytology
|2 MeSH
650 _ 2 |a Cerebral Cortex: embryology
|2 MeSH
650 _ 2 |a Destrin: physiology
|2 MeSH
650 _ 2 |a Growth Cones: metabolism
|2 MeSH
650 _ 2 |a Hippocampus: cytology
|2 MeSH
650 _ 2 |a Hippocampus: embryology
|2 MeSH
650 _ 2 |a In Vitro Techniques
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Microtubules: physiology
|2 MeSH
650 _ 2 |a Neurites: metabolism
|2 MeSH
650 _ 2 |a Neurogenesis: physiology
|2 MeSH
700 1 _ |a Hellal, Farida
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700 1 _ |a Neukirchen, Dorothee
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700 1 _ |a Jacob, Sonja
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700 1 _ |a Tahirovic, Sabina
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700 1 _ |a Dupraz, Sebastian
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700 1 _ |a Stern, Sina
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700 1 _ |a Garvalov, Boyan K
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700 1 _ |a Gurniak, Christine
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700 1 _ |a Shaw, Alisa E
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700 1 _ |a Meyn, Liane
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700 1 _ |a Wedlich-Söldner, Roland
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700 1 _ |a Bamburg, James R
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700 1 _ |a Small, J Victor
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700 1 _ |a Witke, Walter
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700 1 _ |a Bradke, Frank
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773 1 8 |a 10.1016/j.neuron.2012.09.038
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|t Neuron
|v 76
|y 2012
|x 0896-6273
773 _ _ |a 10.1016/j.neuron.2012.09.038
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