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000136801 1001_ $$0P:(DE-HGF)0$$aScheubert, Lena$$b0
000136801 245__ $$aTissue-based Alzheimer gene expression markers-comparison of multiple machine learning approaches and investigation of redundancy in small biomarker sets.
000136801 260__ $$aHeidelberg$$bSpringer$$c2012
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000136801 520__ $$aAlzheimer's disease has been known for more than 100 years and the underlying molecular mechanisms are not yet completely understood. The identification of genes involved in the processes in Alzheimer affected brain is an important step towards such an understanding. Genes differentially expressed in diseased and healthy brains are promising candidates.Based on microarray data we identify potential biomarkers as well as biomarker combinations using three feature selection methods: information gain, mean decrease accuracy of random forest and a wrapper of genetic algorithm and support vector machine (GA/SVM). Information gain and random forest are two commonly used methods. We compare their output to the results obtained from GA/SVM. GA/SVM is rarely used for the analysis of microarray data, but it is able to identify genes capable of classifying tissues into different classes at least as well as the two reference methods.Compared to the other methods, GA/SVM has the advantage of finding small, less redundant sets of genes that, in combination, show superior classification characteristics. The biological significance of the genes and gene pairs is discussed.
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000136801 650_7 $$2NLM Chemicals$$aGenetic Markers
000136801 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000136801 650_2 $$2MeSH$$aArtificial Intelligence: statistics & numerical data
000136801 650_2 $$2MeSH$$aGene Expression
000136801 650_2 $$2MeSH$$aGene Expression Profiling: statistics & numerical data
000136801 650_2 $$2MeSH$$aGenetic Markers
000136801 650_2 $$2MeSH$$aHumans
000136801 650_2 $$2MeSH$$aOligonucleotide Array Sequence Analysis: statistics & numerical data
000136801 650_2 $$2MeSH$$aSupport Vector Machine
000136801 650_2 $$2MeSH$$aTissue Array Analysis: statistics & numerical data
000136801 7001_ $$0P:(DE-HGF)0$$aLuštrek, Mitja$$b1
000136801 7001_ $$0P:(DE-HGF)0$$aSchmidt, Rainer$$b2
000136801 7001_ $$0P:(DE-HGF)0$$aRepsilber, Dirk$$b3$$eCorresponding author
000136801 7001_ $$0P:(DE-2719)9000086$$aFuellen, Georg$$b4$$eLast author$$udzne
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