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000136804 0247_ $$2doi$$a10.1523/JNEUROSCI.3356-12.2013
000136804 0247_ $$2pmid$$apmid:23426673
000136804 0247_ $$2pmc$$apmc:PMC6619533
000136804 0247_ $$2ISSN$$a0270-6474
000136804 0247_ $$2ISSN$$a1529-2401
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000136804 037__ $$aDZNE-2020-03126
000136804 041__ $$aEnglish
000136804 082__ $$a610
000136804 1001_ $$0P:(DE-2719)2812366$$aKerimoglu, Cemil$$b0$$eFirst author$$udzne
000136804 245__ $$aHistone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice.
000136804 260__ $$aWashington, DC$$bSoc.57413$$c2013
000136804 264_1 $$2Crossref$$3online$$bSociety for Neuroscience$$c2013-02-20
000136804 264_1 $$2Crossref$$3print$$bSociety for Neuroscience$$c2013-02-20
000136804 3367_ $$2DRIVER$$aarticle
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000136804 3367_ $$2BibTeX$$aARTICLE
000136804 3367_ $$2ORCID$$aJOURNAL_ARTICLE
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000136804 520__ $$aThe consolidation of long-term memories requires differential gene expression. Recent research has suggested that dynamic changes in chromatin structure play a role in regulating the gene expression program linked to memory formation. The contribution of histone methylation, an important regulatory mechanism of chromatin plasticity that is mediated by the counteracting activity of histone-methyltransferases and histone-demethylases, is, however, not well understood. Here we show that mice lacking the histone-methyltransferase myeloid/lymphoid or mixed-lineage leukemia 2 (mll2/kmt2b) gene in adult forebrain excitatory neurons display impaired hippocampus-dependent memory function. Consistent with the role of KMT2B in gene-activation DNA microarray analysis revealed that 152 genes were downregulated in the hippocampal dentate gyrus region of mice lacking kmt2b. Downregulated plasticity genes showed a specific deficit in histone 3 lysine 4 di- and trimethylation, while histone 3 lysine 4 monomethylation was not affected. Our data demonstrates that KMT2B mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation.
000136804 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000136804 542__ $$2Crossref$$i2013-08-20$$uhttps://creativecommons.org/licenses/by-nc-sa/4.0/
000136804 588__ $$aDataset connected to CrossRef, PubMed,
000136804 650_7 $$2NLM Chemicals$$aDNA-Binding Proteins
000136804 650_7 $$2NLM Chemicals$$aKMT2D protein, human
000136804 650_7 $$2NLM Chemicals$$aNeoplasm Proteins
000136804 650_7 $$0EC 2.1.1.-$$2NLM Chemicals$$aHistone Methyltransferases
000136804 650_7 $$0EC 2.1.1.43$$2NLM Chemicals$$aHistone-Lysine N-Methyltransferase
000136804 650_2 $$2MeSH$$aAnimals
000136804 650_2 $$2MeSH$$aDNA-Binding Proteins: deficiency
000136804 650_2 $$2MeSH$$aDNA-Binding Proteins: genetics
000136804 650_2 $$2MeSH$$aDNA-Binding Proteins: physiology
000136804 650_2 $$2MeSH$$aHippocampus: enzymology
000136804 650_2 $$2MeSH$$aHistone Methyltransferases
000136804 650_2 $$2MeSH$$aHistone-Lysine N-Methyltransferase: deficiency
000136804 650_2 $$2MeSH$$aHistone-Lysine N-Methyltransferase: genetics
000136804 650_2 $$2MeSH$$aMaze Learning: physiology
000136804 650_2 $$2MeSH$$aMemory, Long-Term: physiology
000136804 650_2 $$2MeSH$$aMice
000136804 650_2 $$2MeSH$$aMice, Inbred C57BL
000136804 650_2 $$2MeSH$$aMice, Knockout
000136804 650_2 $$2MeSH$$aMice, Transgenic
000136804 650_2 $$2MeSH$$aNeoplasm Proteins: deficiency
000136804 650_2 $$2MeSH$$aNeoplasm Proteins: genetics
000136804 650_2 $$2MeSH$$aNeoplasm Proteins: physiology
000136804 650_2 $$2MeSH$$aNeuronal Plasticity: genetics
000136804 650_2 $$2MeSH$$aNeuronal Plasticity: physiology
000136804 7001_ $$0P:(DE-2719)9000006$$aAgis-Balboa, Roberto C$$b1$$udzne
000136804 7001_ $$0P:(DE-HGF)0$$aKranz, Andrea$$b2
000136804 7001_ $$0P:(DE-2719)9000302$$aStilling, Roman$$b3$$udzne
000136804 7001_ $$0P:(DE-2719)2812926$$aBahari-Javan, Sanaz$$b4$$udzne
000136804 7001_ $$0P:(DE-2719)2810482$$aBenito Garagorri, Eva$$b5$$udzne
000136804 7001_ $$0P:(DE-2719)2810512$$aHalder, Rashi$$b6$$udzne
000136804 7001_ $$0P:(DE-2719)2810773$$aBurkhardt, Susanne$$b7$$udzne
000136804 7001_ $$0P:(DE-HGF)0$$aStewart, Adrian Francis$$b8
000136804 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b9$$eLast author$$udzne
000136804 77318 $$2Crossref$$3journal-article$$a10.1523/jneurosci.3356-12.2013$$bSociety for Neuroscience$$d2013-02-20$$n8$$p3452-3464$$tThe Journal of Neuroscience$$v33$$x0270-6474$$y2013
000136804 773__ $$0PERI:(DE-600)1475274-8$$a10.1523/JNEUROSCI.3356-12.2013$$gVol. 33, no. 8, p. 3452 - 3464$$n8$$p3452-3464$$q33:8<3452 - 3464$$tThe journal of neuroscience$$v33$$x0270-6474$$y2013
000136804 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619533
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