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@ARTICLE{Haenisch:136826,
      author       = {Haenisch, Britta and Huber, Michael and Wilhelm, Thomas and
                      Steffens, Michael and Molderings, Gerhard J},
      title        = {{I}nvestigation into mechanisms mediating the inhibitory
                      effect of 1,4-benzodiazepines on mast cells by gene
                      expression profiling.},
      journal      = {Life sciences},
      volume       = {92},
      number       = {6-7},
      issn         = {0024-3205},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-03148},
      pages        = {345-351},
      year         = {2013},
      abstract     = {This study aims to identify by a molecular genetic approach
                      potential targets in mast cells at which 1,4-benzodiazepines
                      may cause their inhibitory effect on mast cell activity.Gene
                      expression analyses with microarray gene chip and/or
                      quantitative PCR were performed using
                      1,4-benzodiazepine-treated human mast cell leukemia HMC-1.2
                      cells, promyelocytic leukemia HL-60 cells and human mast
                      cells from healthy volunteers and patients with mast cell
                      activation disease (MCAD). Pathway analysis was applied to
                      search for enriched biological functions and canonical
                      pathways within differentially regulated genes.Both
                      neoplastic and normal human mast cells express several
                      GABA(A) receptor subunits at the mRNA level. In mast cells
                      from MCAD patients expression of some GABA(A) receptor
                      subunits and expression of the translocator protein TSPO are
                      increased compared with those from healthy controls.
                      Expression of the protein tyrosine kinases Lyn, Fgr and Yes1
                      was increased in HMC-1.2 cells as compared with the
                      ontogenetically related HL60 cells. Differences in gene
                      regulation in HMC-1.2 cells after treatment with the
                      1,4-benzodiazepines clonazepam, flunitrazepam and
                      4-chlorodiazepam suggested that signaling and gene
                      expression induced by clonazepam was similar to that of
                      flunitrazepam but different from that of 4-chlorodiazepam.
                      This conclusion is supported by the results of the pathway
                      analysis.A novel type of GABA(A) receptors on mast cells
                      appears to be involved in the inhibition of mast cell
                      activity by 1,4-benzodiazepines. These receptors seem to be
                      composed without γ subunits suggesting unique
                      pharmacological properties. An action at Src-kinases, or at
                      TSPO located in the plasma membrane may also be involved.},
      keywords     = {Adult / Aged / Benzodiazepinones: pharmacology /
                      Clonazepam: pharmacology / Female / Flunitrazepam:
                      pharmacology / Gene Expression: drug effects / Gene
                      Expression Profiling: methods / HL-60 Cells / Humans / Male
                      / Mast Cells: drug effects / Mastocytosis: genetics /
                      Microarray Analysis: methods / Middle Aged / Polymerase
                      Chain Reaction: methods / Benzodiazepinones (NLM Chemicals)
                      / 4'-chlorodiazepam (NLM Chemicals) / Clonazepam (NLM
                      Chemicals) / Flunitrazepam (NLM Chemicals)},
      cin          = {AG Hänisch},
      ddc          = {570},
      cid          = {I:(DE-2719)1013010},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23352970},
      doi          = {10.1016/j.lfs.2013.01.010},
      url          = {https://pub.dzne.de/record/136826},
}